Discovery of 5-Methylpyrimidopyridone Analogues as Selective Antimycobacterial Agents

2021 ◽  
pp. 116426
Author(s):  
Yu Wu ◽  
Chen-Yi Cheung ◽  
Yang Zhou ◽  
Zhen Wang ◽  
Zhengchao Tu ◽  
...  
Keyword(s):  
Antimycobacterial Agents

scholarly journals Lymphocutaneous spread of Mycobacterium elephantis in an immunocompetent individual: A case report

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110349
Author(s):  
Brett D Edwards ◽  
Ranjani Somayaji ◽  
Dina Fisher ◽  
Justin C Chia
Keyword(s):  
Case Report ◽  
Chronic Lung Disease ◽  
Contaminated Soil ◽  
Lung Abscess ◽  
Immunocompetent Individual ◽  
First Case ◽  
Antimycobacterial Agents ◽  
Vitro Data ◽  
In Vitro Data

Mycobacterium elephantis was first described when isolated from an elephant that succumbed to lung abscess. However, despite this namesake, it is not associated with animals and has been described most often as a probable colonizer rather than pathogen in humans with chronic lung disease. In this report, we describe the first case of lymphocutaneous infection from M. elephantis, likely as a result of cutaneous inoculation with contaminated soil. This offers further evidence to its capabilities as a pathogen. We provide a review of the limited prior reports of M. elephantis and outline the available in vitro data on efficacy of various antimycobacterial agents.

scholarly journals Stereochemical aspects in the synthesis of novel N-(purin-6-yl)dipeptides as potential antimycobacterial agents

Amino Acids ◽  
2021 ◽  
Vol 53 (3) ◽  
pp. 407-415
Author(s):  
Vera V. Musiyak ◽  
Irina A. Nizova ◽  
Evgeny N. Chulakov ◽  
Liliya Sh. Sadretdinova ◽  
Andrey A. Tumashov ◽  
...  
Keyword(s):  
Antimycobacterial Agents

Stereoselective synthesis and discovery of novel spirooxindolopyrrolidine engrafted indandione heterocyclic hybrids as antimycobacterial agents

2021 ◽  
Vol 110 ◽  
pp. 104798
Author(s):  
Natarajan Arumugam ◽  
Abdulrahman I. Almansour ◽  
Raju Suresh Kumar ◽  
Vagolu Siva Krishna ◽  
Dharmarajan Sriram ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Antimycobacterial Agents

Quinolidene based monocarbonyl curcumin analogues as promising antimycobacterial agents: Synthesis and molecular docking study

2017 ◽  
Vol 27 (4) ◽  
pp. 922-928 ◽  
Author(s):  
Dnyaneshwar D. Subhedar ◽  
Mubarak H. Shaikh ◽  
Laxman Nawale ◽  
Dhiman Sarkar ◽  
Vijay M. Khedkar ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Docking Study ◽  
Molecular Docking Study ◽  
Curcumin Analogues ◽  
Antimycobacterial Agents

scholarly journals Indolyl Azaspiroketal Mannich Bases Are Potent Antimycobacterial Agents with Selective Membrane Permeabilizing Effects and in Vivo Activity

2018 ◽  
Vol 61 (13) ◽  
pp. 5733-5750 ◽  
Author(s):  
Samuel Agyei Nyantakyi ◽  
Ming Li ◽  
Pooja Gopal ◽  
Matthew Zimmerman ◽  
Véronique Dartois ◽  
...  
Keyword(s):  
Mannich Bases ◽  
Antimycobacterial Agents ◽  
Selective Membrane

Green approach towards synthesis of substituted pyrazole-1,4-dihydro,9-oxa,1,2,6,8-tetrazacyclopentano[b]naphthalene-5-one derivatives as antimycobacterial agents

2013 ◽  
Vol 22 (11) ◽  
pp. 5197-5203 ◽  
Author(s):  
Santosh S. Chobe ◽  
Rahul D. Kamble ◽  
Snehalkumar D. Patil ◽  
Ashok P. Acharya ◽  
Shrikant V. Hese ◽  
...  
Keyword(s):  
Green Approach ◽  
Antimycobacterial Agents

A facile three-component [3+2]-cycloaddition for the regioselective synthesis of highly functionalised dispiropyrrolidines acting as antimycobacterial agents

2013 ◽  
Vol 23 (5) ◽  
pp. 1383-1386 ◽  
Author(s):  
Ang Chee Wei ◽  
Mohamed Ashraf Ali ◽  
Yeong Keng Yoon ◽  
Rusli Ismail ◽  
Tan Soo Choon ◽  
...  
Keyword(s):  
Regioselective Synthesis ◽  
Antimycobacterial Agents

Drug discovery in tuberculosis. New drug targets and antimycobacterial agents

2018 ◽  
Vol 150 ◽  
pp. 525-545 ◽  
Author(s):  
André Campaniço ◽  
Rui Moreira ◽  
Francisca Lopes
Keyword(s):  
Drug Discovery ◽  
Drug Targets ◽  
New Drug ◽  
Antimycobacterial Agents

Second generation of primaquine ureas and bis-ureas as potential antimycobacterial agents

2018 ◽  
Vol 23 (3) ◽  
pp. 657-667 ◽  
Author(s):  
Kristina Pavić ◽  
Zrinka Rajić ◽  
Hana Michnová ◽  
Josef Jampílek ◽  
Ivana Perković ◽  
...  
Keyword(s):  
Second Generation ◽  
Antimycobacterial Agents
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