Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase

Sergio H. Szajnman; Esteban L. Ravaschino; Roberto Docampo; Juan B. Rodriguez

doi:10.1016/j.bmcl.2005.07.060

Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.07.060 ◽

2005 ◽

Vol 15 (21) ◽

pp. 4685-4690 ◽

Cited By ~ 42

Author(s):

Sergio H. Szajnman ◽

Esteban L. Ravaschino ◽

Roberto Docampo ◽

Juan B. Rodriguez

Keyword(s):

Fatty Acids ◽

Trypanosoma Cruzi ◽

Biological Evaluation ◽

Farnesyl Pyrophosphate ◽

Farnesyl Pyrophosphate Synthase ◽

Synthesis And Biological Evaluation

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Synthesis and Biological Evaluation of 1-Amino-1,1-bisphosphonates Derived from Fatty Acids Against Trypanosoma cruzi Targeting Farnesyl Pyrophosphate Synthase.

ChemInform ◽

10.1002/chin.200605233 ◽

2006 ◽

Vol 37 (5) ◽

Author(s):

Sergio H. Szajnman ◽

Esteban L. Ravaschino ◽

Roberto Docampo ◽

Juan B. Rodriguez

Keyword(s):

Fatty Acids ◽

Trypanosoma Cruzi ◽

Biological Evaluation ◽

Farnesyl Pyrophosphate ◽

Farnesyl Pyrophosphate Synthase ◽

Synthesis And Biological Evaluation

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Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(03)00663-2 ◽

2003 ◽

Vol 13 (19) ◽

pp. 3231-3235 ◽

Cited By ~ 44

Author(s):

Sergio H. Szajnman ◽

Andrea Montalvetti ◽

Youhong Wang ◽

Roberto Docampo ◽

Juan B. Rodriguez

Keyword(s):

Fatty Acids ◽

Trypanosoma Cruzi ◽

Farnesyl Pyrophosphate ◽

Farnesyl Pyrophosphate Synthase

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Synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-a]benzimidazole derivatives against Leishmania donovani and Trypanosoma cruzi

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2014.07.038 ◽

2014 ◽

Vol 84 ◽

pp. 395-403 ◽

Cited By ~ 32

Author(s):

Sangmi Oh ◽

Sungbum Kim ◽

Sunju Kong ◽

Gyongseon Yang ◽

Nakyung Lee ◽

...

Keyword(s):

Trypanosoma Cruzi ◽

Leishmania Donovani ◽

Biological Evaluation ◽

Benzimidazole Derivatives ◽

Synthesis And Biological Evaluation

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ChemInform Abstract: On the Search for Potential anti-Trypanosoma cruzi Drugs: Synthesis and Biological Evaluation of 2-Hydroxy-3-methylamino and 1,2,3-Triazolic Naphthoquinoidal Compounds Obtained by Click Chemistry Reactions.

ChemInform ◽

10.1002/chin.201239148 ◽

2012 ◽

Vol 43 (39) ◽

pp. no-no

Author(s):

Eufranio N. da Silva Junior ◽

et al. et al.

Keyword(s):

Trypanosoma Cruzi ◽

Click Chemistry ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

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On the search for potential anti-Trypanosoma cruzi drugs: Synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1,2,3-triazolic naphthoquinoidal compounds obtained by click chemistry reactions

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2012.03.039 ◽

2012 ◽

Vol 52 ◽

pp. 304-312 ◽

Cited By ~ 40

Author(s):

Eufrânio N. da Silva ◽

Isadora M.M. de Melo ◽

Emilay B.T. Diogo ◽

Verenice A. Costa ◽

José D. de Souza Filho ◽

...

Keyword(s):

Trypanosoma Cruzi ◽

Click Chemistry ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

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Characterization of the farnesyl pyrophosphate synthase of Trypanosoma cruzi by homology modeling and molecular dynamics

Journal of Molecular Graphics and Modelling ◽

10.1016/j.jmgm.2006.02.001 ◽

2006 ◽

Vol 25 (3) ◽

pp. 345-352 ◽

Cited By ~ 4

Author(s):

Lucas Sigman ◽

Verónica Muriel Sánchez ◽

Adrián Gustavo Turjanski

Keyword(s):

Molecular Dynamics ◽

Trypanosoma Cruzi ◽

Homology Modeling ◽

Farnesyl Pyrophosphate ◽

Farnesyl Pyrophosphate Synthase

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Synthesis and biological evaluation of isoxazolyl-sulfonamides: A non-cytotoxic scaffold active against Trypanosoma cruzi, Leishmania amazonensis and Herpes Simplex Virus

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2018.08.040 ◽

2018 ◽

Vol 28 (20) ◽

pp. 3381-3384

Author(s):

Rafael da Rosa ◽

Lara Almida Zimmermann ◽

Milene Höehr de Moraes ◽

Naira Fernanda Zanchett Schneider ◽

Alice Duarte Schappo ◽

...

Keyword(s):

Herpes Simplex Virus ◽

Herpes Simplex ◽

Trypanosoma Cruzi ◽

Biological Evaluation ◽

Leishmania Amazonensis ◽

Simplex Virus ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of 1-alkylaminomethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2019.07.004 ◽

2019 ◽

Vol 27 (16) ◽

pp. 3663-3673 ◽

Cited By ~ 3

Author(s):

Tamila Galaka ◽

Bruno N. Falcone ◽

Catherine Li ◽

Sergio H. Szajnman ◽

Silvia N.J. Moreno ◽

...

Keyword(s):

Toxoplasma Gondii ◽

Trypanosoma Cruzi ◽

Biological Evaluation ◽

Bisphosphonic Acids ◽

Synthesis And Biological Evaluation

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Synthesis and Biological Evaluation of New Sulfonamide Derivatives as Potential Anti-Trypanosoma cruzi Agents

Medicinal Chemistry ◽

10.2174/1573406411208061039 ◽

2012 ◽

Vol 8 (6) ◽

pp. 1039-1044

Author(s):

Virgilio Bocanegra-Garcia ◽

Juan Carlos Villalobos-Rocha ◽

Benjamin Nogueda-Torres ◽

Maria Edith Lemus- Hernandez ◽

Argelia Camargo-Ordonez ◽

...

Keyword(s):

Trypanosoma Cruzi ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

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ChemInform Abstract: Amphimic Acids and Related Long-Chain Fatty Acids as DNA Topoisomerase I Inhibitors from an Australian Sponge, Amphimedon sp.: Isolation, Structure, Synthesis, and Biological Evaluation.

ChemInform ◽

10.1002/chin.199810250 ◽

2010 ◽

Vol 29 (10) ◽

pp. no-no

Author(s):

T. NEMOTO ◽

G. YOSHINO ◽

M. OJIKA ◽

Y. SAKAGAMI

Keyword(s):

Fatty Acids ◽

Topoisomerase I ◽

Biological Evaluation ◽

Dna Topoisomerase I ◽

Long Chain Fatty Acids ◽

Dna Topoisomerase ◽

Topoisomerase I Inhibitors ◽

Structure Synthesis ◽

Synthesis And Biological Evaluation ◽

Long Chain

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