Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors

Irini Akritopoulou-Zanze; Daniel H. Albert; Peter F. Bousquet; George A. Cunha; Christopher M. Harris; Maria Moskey; Jurgen Dinges; Kent D. Stewart; Thomas J. Sowin

doi:10.1016/j.bmcl.2007.03.031

Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2007.03.031 ◽

2007 ◽

Vol 17 (11) ◽

pp. 3136-3140 ◽

Cited By ~ 8

Author(s):

Irini Akritopoulou-Zanze ◽

Daniel H. Albert ◽

Peter F. Bousquet ◽

George A. Cunha ◽

Christopher M. Harris ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation ◽

Receptor Tyrosine Kinase Inhibitors

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The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2012.06.029 ◽

2012 ◽

Vol 22 (15) ◽

pp. 4979-4985 ◽

Cited By ~ 13

Author(s):

Moon H. Kim ◽

Amy Lew Tsuhako ◽

Erick W. Co ◽

Dana T. Aftab ◽

Frauke Bentzien ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Receptor Tyrosine Kinase Inhibitors

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Synthesis and biological evaluation of aeroplysinin analogues: a new class of receptor tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(98)00070-4 ◽

1998 ◽

Vol 6 (8) ◽

pp. 1153-1162 ◽

Cited By ~ 39

Author(s):

Klaus Hinterding ◽

Axel Knebel ◽

Peter Herrlich ◽

Herbert Waldmann

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

New Class ◽

Synthesis And Biological Evaluation ◽

Receptor Tyrosine Kinase Inhibitors

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Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2008.04.019 ◽

2008 ◽

Vol 16 (10) ◽

pp. 5514-5528 ◽

Cited By ~ 22

Author(s):

Aleem Gangjee ◽

Ojas A. Namjoshi ◽

Jianming Yu ◽

Michael A. Ihnat ◽

Jessica E. Thorpe ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

Antiangiogenic Agents ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Multiple Receptor ◽

Receptor Tyrosine Kinase Inhibitors

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Design, synthesis, and biological evaluation of novel 3-pyrrolo[b]cyclohexylene-2-dihydroindolinone derivatives as potent receptor tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2013.08.037 ◽

2013 ◽

Vol 23 (20) ◽

pp. 5630-5633 ◽

Cited By ~ 8

Author(s):

Lei Ding ◽

Feng Tang ◽

Wei Huang ◽

Qiu Jin ◽

Han Shen ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Receptor Tyrosine Kinase Inhibitors

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Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2008.03.021 ◽

2008 ◽

Vol 18 (8) ◽

pp. 2691-2695 ◽

Cited By ~ 20

Author(s):

Vijaya Gracias ◽

Zhiqin Ji ◽

Irini Akritopoulou-Zanze ◽

Cele Abad-Zapatero ◽

Jeffrey R. Huth ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Receptor Tyrosine Kinase Inhibitors

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RETROSPECTIVE REAL-WORLD OUTCOMES FOR ALK-REARRANGED LUNG CANCER PATIENTS RECEIVING ALK-RECEPTOR TYROSINE KINASE INHIBITORS

JTO Clinical and Research Reports ◽

10.1016/j.jtocrr.2021.100157 ◽

2021 ◽

pp. 100157

Author(s):

Amanda J.W. Gibson ◽

Adrian Box ◽

Michelle L. Dean ◽

Anifat A. Elegbede ◽

Desiree Hao ◽

...

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Cancer Patients ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Real World ◽

Kinase Inhibitors ◽

Lung Cancer Patients ◽

Receptor Tyrosine Kinase Inhibitors

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Molecular-Genetic Basis of Gastrointestinal Stromal Tumor Personalized Therapy by Receptor Tyrosine Kinase Inhibitors (A Review)

Pharmaceutical Chemistry Journal ◽

10.1007/s11094-021-02419-8 ◽

2021 ◽

Author(s):

M. T. Kozinova ◽

G. A. Abalakov ◽

D. V. Sharipova ◽

N. L. Shimanovsky

Keyword(s):

Tyrosine Kinase ◽

Gastrointestinal Stromal Tumor ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Genetic Basis ◽

Kinase Inhibitors ◽

Molecular Genetic ◽

Personalized Therapy ◽

Molecular Genetic Basis ◽

Receptor Tyrosine Kinase Inhibitors

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Synthesis and biological evaluation of pyrrolopyridazine derivatives as novel HER-2 tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.09.038 ◽

2009 ◽

Vol 19 (22) ◽

pp. 6437-6440 ◽

Cited By ~ 6

Author(s):

Peng Cho Tang ◽

Jun Feng ◽

Li Huang ◽

Zhe Xu ◽

Ling Cheng ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

Her 2 ◽

Synthesis And Biological Evaluation

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Natural Product Derived Receptor Tyrosine Kinase Inhibitors: Identification of IGF1R, Tie-2, and VEGFR-3 Inhibitors

Angewandte Chemie International Edition ◽

10.1002/1521-3773(20020402)41:7<1174::aid-anie1174>3.0.co;2-v ◽

2002 ◽

Vol 41 (7) ◽

pp. 1174-1178 ◽

Cited By ~ 52

Author(s):

Petra Stahl ◽

Lars Kissau ◽

Ralph Mazitschek ◽

Athanassios Giannis ◽

Herbert Waldmann

Keyword(s):

Tyrosine Kinase ◽

Natural Product ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Receptor Tyrosine Kinase Inhibitors

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Novel azulene-based derivatives as potent multi-receptor tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.08.025 ◽

2010 ◽

Vol 20 (20) ◽

pp. 6129-6132 ◽

Cited By ~ 13

Author(s):

Chih-Hung Chen ◽

On Lee ◽

Chung-Niang Yao ◽

Meng-Yun Chuang ◽

Yow-Lone Chang ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Receptor Tyrosine Kinase Inhibitors

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