Non-nucleoside inhibitors of HCV NS5B polymerase. Part 1: Synthetic and computational exploration of the binding modes of benzothiadiazine and 1,4-benzothiazine HCV NS5b polymerase inhibitors

2009 ◽  
Vol 19 (13) ◽  
pp. 3637-3641 ◽  
Author(s):  
Robert T. Hendricks ◽  
Jay B. Fell ◽  
James F. Blake ◽  
John P. Fischer ◽  
John E. Robinson ◽  
...  
Keyword(s):  
Binding Modes ◽  
Polymerase Inhibitors ◽  
Computational Exploration ◽  
Hcv Ns5b ◽  
Nucleoside Inhibitors ◽  
Ns5b Polymerase

scholarly journals Discovery of N-Arylalkyl-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-carboxamide Derivatives as HCV NS5B Polymerase Inhibitors

ChemMedChem ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. 850-860 ◽  
Author(s):  
Ravindra Ramesh Deore ◽  
Grace Shiahuy Chen ◽  
Pei-Teh Chang ◽  
Ting-Rong Chern ◽  
Shin-Yu Lai ◽  
...  
Keyword(s):  
Polymerase Inhibitors ◽  
Hcv Ns5b ◽  
Ns5b Polymerase

I. Novel HCV NS5B polymerase inhibitors: Discovery of indole 2-carboxylic acids with C3-heterocycles

2011 ◽  
Vol 21 (18) ◽  
pp. 5336-5341 ◽  
Author(s):  
Gopinadhan N. Anilkumar ◽  
Charles A. Lesburg ◽  
Oleg Selyutin ◽  
Stuart B. Rosenblum ◽  
Qingbei Zeng ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Polymerase Inhibitors ◽  
Hcv Ns5b ◽  
Ns5b Polymerase

Discovery of novel potent HCV NS5B polymerase non-nucleoside inhibitors bearing a fused benzofuran scaffold

2018 ◽  
Vol 28 (5) ◽  
pp. 963-968 ◽  
Author(s):  
Min Zhong ◽  
Eric Peng ◽  
Ningwu Huang ◽  
Qi Huang ◽  
Anja Huq ◽  
...  
Keyword(s):  
Hcv Ns5b ◽  
Nucleoside Inhibitors ◽  
Ns5b Polymerase

QSAR study of C allosteric binding site of HCV NS5B polymerase inhibitors by support vector machine

2010 ◽  
Vol 15 (3) ◽  
pp. 645-653 ◽  
Author(s):  
Eslam Pourbasheer ◽  
Siavash Riahi ◽  
Mohammad Reza Ganjali ◽  
Parviz Norouzi
Keyword(s):  
Support Vector Machine ◽  
Binding Site ◽  
Support Vector ◽  
Qsar Study ◽  
Polymerase Inhibitors ◽  
Hcv Ns5b ◽  
Ns5b Polymerase

scholarly journals Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors

2008 ◽  
Vol 36 (5) ◽  
pp. 1482-1496 ◽  
Author(s):  
N. Kaushik-Basu ◽  
A. Bopda-Waffo ◽  
T. T. Talele ◽  
A. Basu ◽  
P. R. R. Costa ◽  
...  
Keyword(s):  
Polymerase Inhibitors ◽  
Hcv Ns5b ◽  
Ns5b Polymerase ◽  
Identification And Characterization

Discovery of 2-aminoisobutyric acid ethyl ester (AIBEE) phosphoramidate prodrugs for delivering nucleoside HCV NS5B polymerase inhibitors

2020 ◽  
Vol 30 (7) ◽  
pp. 126986
Author(s):  
John T. Randolph ◽  
Tongmei Li ◽  
A. Chris Krueger ◽  
Howard R. Heyman ◽  
Hui-Ju Chen ◽  
...  
Keyword(s):  
Ethyl Ester ◽  
Acid Ethyl Ester ◽  
Aminoisobutyric Acid ◽  
Polymerase Inhibitors ◽  
Hcv Ns5b ◽  
Ns5b Polymerase

QSAR and Molecular Docking Directed Synthesis and Preliminary Evaluation of Novel Non-Nucleoside HCV NS5B Polymerase Inhibitors

2017 ◽  
Vol 15 (1) ◽  
pp. 52-56
Author(s):  
Vaishali M. Patil ◽  
Neeraj Masand ◽  
Gurukumar K. R ◽  
Maksim Chudayeu ◽  
Satya Prakash Gupta ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Preliminary Evaluation ◽  
Polymerase Inhibitors ◽  
Directed Synthesis ◽  
Hcv Ns5b ◽  
Ns5b Polymerase
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