Discovery of N-Arylalkyl-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-carboxamide Derivatives as HCV NS5B Polymerase Inhibitors

Non-nucleoside inhibitors of HCV NS5B polymerase. Part 1: Synthetic and computational exploration of the binding modes of benzothiadiazine and 1,4-benzothiazine HCV NS5b polymerase inhibitors

10.1016/j.bmcl.2009.04.119 ◽

2009 ◽

Vol 19 (13) ◽

pp. 3637-3641 ◽

Cited By ~ 25

Author(s):

Robert T. Hendricks ◽

Jay B. Fell ◽

James F. Blake ◽

John P. Fischer ◽

John E. Robinson ◽

...

Keyword(s):

Binding Modes ◽

Polymerase Inhibitors ◽

Computational Exploration ◽

Hcv Ns5b ◽

Nucleoside Inhibitors ◽

I. Novel HCV NS5B polymerase inhibitors: Discovery of indole 2-carboxylic acids with C3-heterocycles

10.1016/j.bmcl.2011.07.021 ◽

2011 ◽

Vol 21 (18) ◽

pp. 5336-5341 ◽

Cited By ~ 31

Author(s):

Gopinadhan N. Anilkumar ◽

Charles A. Lesburg ◽

Oleg Selyutin ◽

Stuart B. Rosenblum ◽

Qingbei Zeng ◽

...

Keyword(s):

Carboxylic Acids ◽

Polymerase Inhibitors ◽

Hcv Ns5b ◽

HCV NS5B polymerase inhibitors 3: Synthesis and in vitro activity of 3-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-4-hydroxy-2H-quinolizin-2-one derivatives

10.1016/j.bmcl.2009.05.021 ◽

2009 ◽

Vol 19 (15) ◽

pp. 4484-4487 ◽

Cited By ~ 9

Author(s):

Guangyi Wang ◽

Laiguo Zhang ◽

Xiaomin Wu ◽

Debasis Das ◽

Donald Ruhrmund ◽

...

Keyword(s):

Vitro Activity ◽

In Vitro Activity ◽

Polymerase Inhibitors ◽

Hcv Ns5b ◽

HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives

10.1016/j.bmcl.2009.05.022 ◽

2009 ◽

Vol 19 (15) ◽

pp. 4480-4483 ◽

Cited By ~ 14

Author(s):

Guangyi Wang ◽

Huoxing Lei ◽

Xiaofang Wang ◽

Debasis Das ◽

Jian Hong ◽

...

Keyword(s):

Vitro Activity ◽

In Vitro Activity ◽

Pyrimidine Derivatives ◽

Polymerase Inhibitors ◽

Hcv Ns5b ◽

QSAR study of C allosteric binding site of HCV NS5B polymerase inhibitors by support vector machine

Molecular Diversity ◽

10.1007/s11030-010-9283-0 ◽

2010 ◽

Vol 15 (3) ◽

pp. 645-653 ◽

Cited By ~ 16

Author(s):

Eslam Pourbasheer ◽

Siavash Riahi ◽

Mohammad Reza Ganjali ◽

Parviz Norouzi

Keyword(s):

Support Vector Machine ◽

Binding Site ◽

Support Vector ◽

Qsar Study ◽

Polymerase Inhibitors ◽

Hcv Ns5b ◽

Identification And Characterization

Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors

Nucleic Acids Research ◽

10.1093/nar/gkm1178 ◽

2008 ◽

Vol 36 (5) ◽

pp. 1482-1496 ◽

Cited By ~ 60

Author(s):

N. Kaushik-Basu ◽

A. Bopda-Waffo ◽

T. T. Talele ◽

A. Basu ◽

P. R. R. Costa ◽

...

Keyword(s):

Polymerase Inhibitors ◽

Hcv Ns5b ◽

Ns5b Polymerase ◽

Discovery of 2-aminoisobutyric acid ethyl ester (AIBEE) phosphoramidate prodrugs for delivering nucleoside HCV NS5B polymerase inhibitors

10.1016/j.bmcl.2020.126986 ◽

2020 ◽

Vol 30 (7) ◽

pp. 126986

Author(s):

John T. Randolph ◽

Tongmei Li ◽

A. Chris Krueger ◽

Howard R. Heyman ◽

Hui-Ju Chen ◽

...

Keyword(s):

Ethyl Ester ◽

Acid Ethyl Ester ◽

Aminoisobutyric Acid ◽

Polymerase Inhibitors ◽

Hcv Ns5b ◽

QSAR and Molecular Docking Directed Synthesis and Preliminary Evaluation of Novel Non-Nucleoside HCV NS5B Polymerase Inhibitors

Anti-Infective Agents ◽

10.2174/2211352514666161125124846 ◽

2017 ◽

Vol 15 (1) ◽

pp. 52-56

Author(s):

Vaishali M. Patil ◽

Neeraj Masand ◽

Gurukumar K. R ◽

Maksim Chudayeu ◽

Satya Prakash Gupta ◽

...

Keyword(s):

Molecular Docking ◽

Preliminary Evaluation ◽

Polymerase Inhibitors ◽

Directed Synthesis ◽

Hcv Ns5b ◽

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents

10.1016/j.bmcl.2008.01.005 ◽

2008 ◽

Vol 18 (4) ◽

pp. 1419-1424 ◽

Cited By ~ 23

Author(s):

Yuefen Zhou ◽

Lian-Sheng Li ◽

Peter S. Dragovich ◽

Douglas E. Murphy ◽

Chinh V. Tran ◽

...

Keyword(s):

Polymerase Inhibitors ◽

Hcv Ns5b ◽

Design and Development of HCV NS5B Polymerase Inhibitors

Viral Proteases and Their Inhibitors ◽

10.1016/b978-0-12-809712-0.00008-3 ◽

2017 ◽

pp. 189-219

Author(s):

Debasis Das

Keyword(s):

Design And Development ◽

Polymerase Inhibitors ◽

Hcv Ns5b ◽