Discovery of novel α7 nicotinic acetylcholine receptor ligands via pharmacophoric and docking studies of benzylidene anabaseine analogs

Docking Studies ◽

Receptor Ligands ◽

Nicotinic Acetylcholine ◽

Benzylidene Anabaseine

Docking studies of benzylidene anabaseine interactions with α7 nicotinic acetylcholine receptor (nAChR) and acetylcholine binding proteins (AChBPs): Application to the design of related α7 selective ligands

10.1016/j.ejmech.2011.09.033 ◽

2011 ◽

Vol 46 (11) ◽

pp. 5625-5635 ◽

Cited By ~ 12

Author(s):

David C. Kombo ◽

Anatoly Mazurov ◽

Kartik Tallapragada ◽

Philip S. Hammond ◽

Joseph Chewning ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Binding Proteins ◽

Docking Studies ◽

Nicotinic Acetylcholine ◽

Selective Ligands ◽

Acetylcholine Binding Proteins ◽

Benzylidene Anabaseine

3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride protects against 6-hydroxydopamine-induced parkinsonian neurodegeneration through α7 nicotinic acetylcholine receptor stimulation in rats

Journal of Neuroscience Research ◽

10.1002/jnr.23160 ◽

2012 ◽

Vol 91 (3) ◽

pp. 462-471 ◽

Cited By ~ 35

Author(s):

Syuuichirou Suzuki ◽

Jun Kawamata ◽

Takashi Matsushita ◽

Akihiro Matsumura ◽

Shin Hisahara ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Receptor Stimulation ◽

Nicotinic Acetylcholine ◽

6 Hydroxydopamine ◽

Benzylidene Anabaseine

The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia

Journal of Neuroimmunology ◽

10.1016/j.jneuroim.2012.07.006 ◽

2012 ◽

Vol 251 (1-2) ◽

pp. 65-72 ◽

Cited By ~ 66

Author(s):

Morten S. Thomsen ◽

Jens D. Mikkelsen

Keyword(s):

Acetylcholine Receptor ◽

Receptor Ligands ◽

Nicotinic Acetylcholine ◽

Tnf Α

Two Novel α7 Nicotinic Acetylcholine Receptor Ligands: In Vitro Properties and Their Efficacy in Collagen-Induced Arthritis in Mice

PLoS ONE ◽

10.1371/journal.pone.0116227 ◽

2015 ◽

Vol 10 (1) ◽

pp. e0116227 ◽

Cited By ~ 25

Author(s):

Marjolein A. van Maanen ◽

Roger L. Papke ◽

Frieda A. Koopman ◽

Jessica Koepke ◽

Lisette Bevaart ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Receptor Ligands ◽

Collagen Induced Arthritis ◽

Bis(het)aryl-1,2,3-triazole quinuclidines as α7 nicotinic acetylcholine receptor ligands: Synthesis, structure affinity relationships, agonism activity, [18F]-radiolabeling and PET study in rats

10.1016/j.ejmech.2019.06.049 ◽

2019 ◽

Vol 179 ◽

pp. 449-469 ◽

Cited By ~ 1

Author(s):

Aziz Ouach ◽

Johnny Vercouillie ◽

Emilie Bertrand ◽

Nuno Rodrigues ◽

Frederic Pin ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Receptor Ligands ◽

Design of α7 nicotinic acetylcholine receptor ligands using the (het)Aryl-1,2,3-triazole core: Synthesis, in vitro evaluation and SAR studies

10.1016/j.ejmech.2015.11.001 ◽

2016 ◽

Vol 107 ◽

pp. 153-164 ◽

Cited By ~ 8

Author(s):

Aziz Ouach ◽

Frederic Pin ◽

Emilie Bertrand ◽

Johnny Vercouillie ◽

Zuhal Gulhan ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Receptor Ligands ◽

Nicotinic Acetylcholine ◽

In Vitro Evaluation ◽

Sar Studies

Design of α7 nicotinic acetylcholine receptor ligands in quinuclidine, tropane and quinazoline series. Chemistry, molecular modeling, radiochemistry, in vitro and in rats evaluations of a [18F] quinuclidine derivative

10.1016/j.ejmech.2014.04.057 ◽

2014 ◽

Vol 82 ◽

pp. 214-224 ◽

Cited By ~ 10

Author(s):

Frédéric Pin ◽

Johnny Vercouillie ◽

Aziz Ouach ◽

Sylvie Mavel ◽

Zuhal Gulhan ◽

...

Keyword(s):

Molecular Modeling ◽

Acetylcholine Receptor ◽

Receptor Ligands ◽

Activation of α7 nicotinic acetylcholine receptor alleviates cerebral cortical neuron injury induced by oxygen-glucose deprivation

Academic Journal of Second Military Medical University ◽

10.3724/sp.j.1008.2015.00472 ◽

2015 ◽

Vol 36 (5) ◽

pp. 472

Author(s):

Ru-juan XIN ◽

Ting ZHAO ◽

Min NI ◽

Dong-jie LI ◽

Fu-ming SHEN

Keyword(s):

Cortical Neuron ◽

Acetylcholine Receptor ◽

Glucose Deprivation ◽

Oxygen Glucose Deprivation ◽

Nicotinic Acetylcholine ◽

Cerebral Cortical Neuron ◽

Neuron Injury

Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach

10.1016/j.ejmech.2021.113189 ◽

2021 ◽

Vol 214 ◽

pp. 113189

Author(s):

István Ledneczki ◽

Pál Tapolcsányi ◽

Eszter Gábor ◽

András Visegrády ◽

Márton Vass ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Allosteric Modulators ◽

Scaffold Hopping ◽

Nicotinic Acetylcholine ◽

Positive Allosteric Modulators

Retracted : Role of α7‐nicotinic acetylcholine receptor in human non‐small cell lung cancer proliferation

Cell Proliferation ◽

10.1111/j.1365-2184.2008.00566.x ◽

2008 ◽

Vol 41 (6) ◽

pp. 936-959 ◽

Cited By ~ 57

Author(s):

L. Paleari ◽

A. Catassi ◽

M. Ciarlo ◽

Z. Cavalieri ◽

C. Bruzzo ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Acetylcholine Receptor ◽

Small Cell ◽

Small Cell Lung ◽

Cancer Proliferation ◽