Synthesis and evaluation of tetrahedral intermediate mimic inhibitors of 3-deoxy-d-manno-octulosonate 8-phosphate synthase

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2011.12.025 ◽

2012 ◽

Vol 22 (2) ◽

pp. 907-911 ◽

Author(s):

Aidan N. Harrison ◽

Sebastian Reichau ◽

Emily J. Parker

Keyword(s):

Tetrahedral Intermediate ◽

Phosphate Synthase

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"Kinetic competence" of the 5-enolpyruvoylshikimate-3-phosphate synthase tetrahedral intermediate.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)39398-6 ◽

1990 ◽

Vol 265 (10) ◽

pp. 5567-5572

Author(s):

K S Anderson ◽

K A Johnson

Keyword(s):

Tetrahedral Intermediate ◽

Phosphate Synthase

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5-Enolpyruvylshikimate 3-Phosphate Synthase: Chemical Synthesis of the Tetrahedral Intermediate and Assignment of the Stereochemical Course of the Enzymatic Reaction

Journal of the American Chemical Society ◽

10.1021/ja036627+ ◽

2003 ◽

Vol 125 (42) ◽

pp. 12759-12767 ◽

Author(s):

Ming An ◽

Uday Maitra ◽

Ulf Neidlein ◽

Paul A. Bartlett

Keyword(s):

Chemical Synthesis ◽

Enzymatic Reaction ◽

Tetrahedral Intermediate ◽

Phosphate Synthase

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Human medicines European public assessment report (EPAR): Pheburane, sodium phenylbutyrate, Carbamoyl-Phosphate Synthase I Deficiency Disease, Date of authorisation: 30/07/2013, Revision: 7, Status: Authorised

Case Medical Research ◽

10.31525/cmr-587238 ◽

2019 ◽

Author(s):

Keyword(s):

Deficiency Disease ◽

Carbamoyl Phosphate ◽

Assessment Report ◽

European Public ◽

European Public Assessment Report ◽

Phosphate Synthase ◽

Sodium Phenylbutyrate

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Human medicines European public assessment report (EPAR): Ammonaps, sodium phenylbutyrate, Ornithine Carbamoyltransferase Deficiency Disease,Citrullinemia,Carbamoyl-Phosphate Synthase I Deficiency Disease, Date of authorisation: 07/12/1999, Revision: 18, Status: Authorised

Case Medical Research ◽

10.31525/cmr-559103 ◽

2019 ◽

Author(s):

Keyword(s):

Ornithine Carbamoyltransferase ◽

Deficiency Disease ◽

Carbamoyl Phosphate ◽

Assessment Report ◽

European Public ◽

European Public Assessment Report ◽

Phosphate Synthase ◽

Sodium Phenylbutyrate

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Faculty Opinions recommendation of X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1001454.15407 ◽

2001 ◽

Author(s):

Brian Shoichet

Keyword(s):

Serine Protease ◽

X Ray ◽

Tetrahedral Intermediate

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Faculty Opinions recommendation of Differential expression of sucrose-phosphate synthase isoenzymes in tobacco reflects their functional specialization during dark-governed starch mobilization in source leaves.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1029212.342609 ◽

2005 ◽

Author(s):

Richard Leegood

Keyword(s):

Differential Expression ◽

Sucrose Phosphate Synthase ◽

Functional Specialization ◽

Starch Mobilization ◽

Sucrose Phosphate ◽

Phosphate Synthase

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Faculty Opinions recommendation of Elimination of 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid 9-phosphate synthase activity from human N-acetylneuraminic acid 9-phosphate synthase by a single mutation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1031512.368710 ◽

2006 ◽

Author(s):

Garry Dotson

Keyword(s):

Single Mutation ◽

Acetylneuraminic Acid ◽

Nonulosonic Acid ◽

Phosphate Synthase

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Faculty Opinions recommendation of A "radical dance" in thiamin biosynthesis: mechanistic analysis of the bacterial hydroxymethylpyrimidine phosphate synthase.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.7172957.7407055 ◽

2010 ◽

Author(s):

Wolfgang Buckel

Keyword(s):

Thiamin Biosynthesis ◽

Mechanistic Analysis ◽

Phosphate Synthase

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Catalytic Mechanism of 3-Deoxy-D-manno-2-octulosonate-8-phosphate Synthase

Current Organic Chemistry ◽

10.2174/1385272013375661 ◽

2001 ◽

Vol 5 (2) ◽

pp. 127-138 ◽

Author(s):

Timor Baasov ◽

Rachel Tkacz ◽

Shani Sheffer-Dee-Noor ◽

Valery Belakhov

Keyword(s):

Catalytic Mechanism ◽

Phosphate Synthase

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Identification of the reactive cysteines of Escherichia coli 5-enolpyruvylshikimate-3-phosphate synthase and their nonessentiality for enzymatic catalysis.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)77947-2 ◽

1988 ◽

Vol 263 (4) ◽

pp. 1798-1802

Author(s):

S R Padgette ◽

Q K Huynh ◽

S Aykent ◽

R D Sammons ◽

J A Sikorski ◽

...

Keyword(s):

Escherichia Coli ◽

Enzymatic Catalysis ◽

Phosphate Synthase

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