Ten food that boost Immune System: A Review

The immunity and system functions to fight against infections square measure considerably wedged by inappropriate food and nutrition. Long run deficiency disease is universally thought-about because the leading explanation for system deficiency. A considerable proportion of the worldwide population doesn't meet the counselled daily intake of nutrient. The COVID-19 pandemic has targeted attention on the role of the system, with health scientists and nutritionists urging folks to require supplements and/or eat specific foods (nutrients) to super-charge their immune systems. The system is that the most complicated system of physical structure. For this we have a tendency to needed the supplements like food for maintenance of system.in this article here could be a discussion of foods like Citrus fruits like lemon, orange, lime etc., broccoli, spinach, turmeric, yoghurt, kiwi, garlic, papaya, almonds, ginger, tulsi, etc things helps in boosting our immunity to fight against infections. In this report, foods that helps in maintain system or immunity boosting material is mentioned.

Dysbetalipoproteinemia: differentiating multifactorial remnant cholesterol disease from genetic apoE deficiency

Background Dysbetalipoproteinemia (DBL) is characterized by the accumulation of remnant lipoprotein particles and associated with an increased risk of cardiovascular and peripheral vascular disease (PVD). DBL is thought to be mainly caused by the presence of an E2/E2 genotype of the apolipoprotein E (APOE) gene, in addition to environmental factors. However, there exists considerable variability in the phenotype of these patients. Objective The objectives were to verify the proportion of DBL subjects diagnosed using the gold standard Fredrickson criteria who did not carry E2/E2 and to compare the clinical characteristics of DBL patients with vs without E2/E2. Methods A total of 12 432 patients with lipoprotein ultracentrifugation as well as APOE genotype or apoE phenotype data were included in the present retrospective study. Results Among the 12 432 patients, 4% (n=524) were positive for Fredrickson criteria (F+), and only 38% (n=197) of the F+ individuals were E2/E2. The F+ E2/E2 group had significantly higher remnant cholesterol concentration (3.44 vs 1.89 mmol/L) and had higher frequency of DBL-related xanthomas (24% vs 2%) and floating beta (95% vs 11%) than the F+ non-E2/E2 group (p<0.0001). The F+ E2/E2 group had an independent higher risk of PVD (OR 11.12 (95% CI 1.87-66.05) p=0.008) events compared to the F+ non-E2/E2 group. Conclusion In the largest cohort of DBL worldwide, we demonstrated that the presence of E2/E2 was associated with a more severe DBL phenotype. We suggest that two dysbetalipoproteinemia phenotypes should be distinguished: the multifactorial remnant cholesterol disease and the genetic apoE deficiency disease.

Interleukin Deficiency Disorder Patient Responses to COVID-19 Infections

Background: The chemokine, cytokine interleukin deficiency disorder defines the immune deficiency disease of fibromyalgia and a reduced ability to produce IL-6 and IL-8. Recent research has demonstrated improved outcomes in COVID-19 infections treated with IL-6 antagonists.9 These fibromyalgia cytokine deficient patients were screened for COVID-19 infections and associated morbidity and mortality rates. Methods: Two cohorts of FM/a test positive fibromyalgia patients were evaluated. Initially, 4,631 patients were screened to determine the occurrence of known COVID-19 infections. Subsequently, 2,195 FM/a test positive patients underwent COVID-19 antibody testing. Results: A total of 7,375 fibromyalgia patients were screened for the occurrence of COVID-19 infections. Of these, 4,631 individuals responded to an email-based inquiry to determine the occurrence of documented COVID-19 infections. Only 10 reported having symptoms consistent with and were diagnosed with COVID-19 by a healthcare professional, making for an incidence of .22%. Another 2,195 fibromyalgia patients completed health questionnaires and COVID-19 antibody testing and 82 had evidence of COVID-19 antibodies with 42 exhibiting symptoms and confirmed diagnoses. Of the remaining, 23 were asymptomatic. There were no deaths and only 1 hospitalization in this group. Conclusion: Individuals with FM/a test positive fibromyalgia have a reduced ability to produce IL-6 and IL-8 which play significant roles in the cytokine storm complications associated with COVID-19 infections. When screened for evidence of past COVID-19 infections, these patients experienced an extremely low incidence of COVID-19 infections based upon antibody testing, there were no mortalities and the level of morbidity was significantly below what has been reported in general populations.

Global Vitamin C Status and Prevalence of Deficiency: A Cause for Concern?

Vitamin C is an essential nutrient that must be obtained through the diet in adequate amounts to prevent hypovitaminosis C, deficiency and its consequences—including the potentially fatal deficiency disease scurvy. Global vitamin C status and prevalence of deficiency has not previously been reported, despite vitamin C’s pleiotropic roles in both non-communicable and communicable disease. This review highlights the global literature on vitamin C status and the prevalence of hypovitaminosis C and deficiency. Related dietary intake is reported if assessed in the studies. Overall, the review illustrates the shortage of high quality epidemiological studies of vitamin C status in many countries, particularly low- and middle-income countries. The available evidence indicates that vitamin C hypovitaminosis and deficiency is common in low- and middle-income countries and not uncommon in high income settings. Further epidemiological studies are required to confirm these findings, to fully assess the extent of global vitamin C insufficiency, and to understand associations with a range of disease processes. Our findings suggest a need for interventions to prevent deficiency in a range of at risk groups and regions of the world.

Genetic Anomalies of Growth Hormone Deficiency in Pediatrics

: Several different proteins regulate, directly or indirectly, the production of growth hormone from the pituitary gland, thereby complex genetics is involved. Defects in these genes are related to growth hormone deficiency solely, or deficiency of other hormones, secreted from the pituitary gland including growth hormone. These studies can aid clinicians to trace the pattern of the disease between the families, start early treatment and predict possible future consequences. This paper highlights some of the most common and novel genetic anomalies concerning growth hormone, which are responsible for various genetic defects in isolated growth and combined pituitary hormone deficiency disease.