Discovery of novel dihydroimidazothiazole derivatives as p53–MDM2 protein–protein interaction inhibitors: Synthesis, biological evaluation and structure–activity relationships

Synthesis and biological evaluation of thio-benzodiazepines as novel small molecule inhibitors of the p53–MDM2 protein–protein interaction

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2011.09.043 ◽

2011 ◽

Vol 46 (11) ◽

pp. 5654-5661 ◽

Cited By ~ 17

Author(s):

Chunlin Zhuang ◽

Zhenyuan Miao ◽

Lingjian Zhu ◽

Yongqiang Zhang ◽

Zizhao Guo ◽

...

Keyword(s):

Small Molecule ◽

Protein Interaction ◽

Small Molecule Inhibitors ◽

Biological Evaluation ◽

Mdm2 Protein ◽

ChemInform Abstract: Synthesis and Biological Evaluation of Thio-benzodiazepines as Novel Small Molecule Inhibitors of the p53-MDM2 Protein-Protein Interaction.

ChemInform ◽

10.1002/chin.201212183 ◽

2012 ◽

Vol 43 (12) ◽

pp. no-no

Author(s):

Chunquan Sheng ◽

et al. et al.

Keyword(s):

Small Molecule ◽

Protein Interaction ◽

Small Molecule Inhibitors ◽

Biological Evaluation ◽

Mdm2 Protein ◽

Developing structure–activity relationships from an HTS hit for inhibition of the Cks1–Skp2 protein–protein interaction

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2015.09.067 ◽

2015 ◽

Vol 25 (22) ◽

pp. 5199-5202 ◽

Cited By ~ 15

Author(s):

Rajinder Singh ◽

Arvinder Sran ◽

David C. Carroll ◽

Jianing Huang ◽

Lyuben Tsvetkov ◽

...

Keyword(s):

Protein Interaction ◽

Structure Activity ◽

Skp2 Protein

Discovery, Synthesis, and Biological Evaluation of Orally Active Pyrrolidone Derivatives as Novel Inhibitors of p53–MDM2 Protein–Protein Interaction

10.1021/jm300969t ◽

2012 ◽

Vol 55 (22) ◽

pp. 9630-9642 ◽

Cited By ~ 76

Author(s):

Chunlin Zhuang ◽

Zhenyuan Miao ◽

Lingjian Zhu ◽

Guoqiang Dong ◽

Zizhao Guo ◽

...

Keyword(s):

Protein Interaction ◽

Biological Evaluation ◽

Mdm2 Protein ◽

Orally Active ◽

Synthesis and Biological Evaluation of Novel Dispiro Compounds based on 5-Arylidenehydantoins and Isatins as Inhibitors of p53–MDM2 Protein–Protein Interaction

Chemistry of Heterocyclic Compounds ◽

10.1007/s10593-020-02726-0 ◽

2020 ◽

Vol 56 (6) ◽

pp. 747-755

Author(s):

Anastasia Beloglazkina ◽

Alexander Barashkin ◽

Vladislav Polyakov ◽

German Kotovsky ◽

Nikita Karpov ◽

...

Keyword(s):

Protein Interaction ◽

Biological Evaluation ◽

Mdm2 Protein ◽

Design, Synthesis, and Structure–Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein–Protein Interaction Inhibitors

10.1021/acs.jmedchem.0c01116 ◽

2020 ◽

Vol 63 (19) ◽

pp. 11149-11168 ◽

Cited By ~ 1

Author(s):

Hai-Shan Zhou ◽

Lv-Bin Hu ◽

Han Zhang ◽

Wen-Xin Shan ◽

Yan Wang ◽

...

Keyword(s):

Protein Interaction ◽

Nuclear Factor ◽

Design Synthesis ◽

Structure Activity ◽

Nrf2 Protein

Structure–activity relationship and antitumor activity of thio-benzodiazepines as p53–MDM2 protein–protein interaction inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2012.08.003 ◽

2012 ◽

Vol 56 ◽

pp. 10-16 ◽

Cited By ~ 21

Author(s):

Zizhao Guo ◽

Chunlin Zhuang ◽

Lingjian Zhu ◽

Yongqiang Zhang ◽

Jianzhong Yao ◽

...

Keyword(s):

Antitumor Activity ◽

Protein Interaction ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Mdm2 Protein ◽

4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA–PB1 Protein–Protein Interaction: Structure–Activity Relationships Exploration with the Aid of Molecular Modeling

10.1021/acs.jmedchem.5b01935 ◽

2016 ◽

Vol 59 (6) ◽

pp. 2688-2703 ◽

Cited By ~ 29

Author(s):

Iuni M. L. Trist ◽

Giulio Nannetti ◽

Cristina Tintori ◽

Anna Lucia Fallacara ◽

Davide Deodato ◽

...

Keyword(s):

Molecular Modeling ◽

Protein Interaction ◽

Interaction Structure ◽

Discovery and structure–activity relationships of small molecules that block the human immunoglobulin G–human neonatal Fc receptor (hIgG–hFcRn) protein–protein interaction

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2013.01.014 ◽

2013 ◽

Vol 23 (5) ◽

pp. 1253-1256 ◽

Cited By ~ 11

Author(s):

Zhaolin Wang ◽

Cara Fraley ◽

Adam R. Mezo

Keyword(s):

Small Molecules ◽

Protein Interaction ◽

Immunoglobulin G ◽

Fc Receptor ◽

Human Immunoglobulin ◽

Neonatal Fc Receptor ◽

Human Immunoglobulin G ◽

Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 18.1N-Substituted 14-Phenylpropyloxymorphinan-6-ones with Unanticipated Agonist Properties: Extending the Scope of Common Structure−Activity Relationships

10.1021/jm021118o ◽

2003 ◽

Vol 46 (9) ◽

pp. 1758-1763 ◽

Cited By ~ 23

Author(s):

Elisabeth Greiner ◽

Mariana Spetea ◽

Roland Krassnig ◽

Falko Schüllner ◽

Mario Aceto ◽

...

Keyword(s):

Biological Evaluation ◽

Common Structure ◽

Structure Activity ◽