Discovery, Synthesis, and Biological Evaluation of Orally Active Pyrrolidone Derivatives as Novel Inhibitors of p53–MDM2 Protein–Protein Interaction

Orally Active ◽

Synthesis and biological evaluation of thio-benzodiazepines as novel small molecule inhibitors of the p53–MDM2 protein–protein interaction

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2011.09.043 ◽

2011 ◽

Vol 46 (11) ◽

pp. 5654-5661 ◽

Cited By ~ 17

Author(s):

Chunlin Zhuang ◽

Zhenyuan Miao ◽

Lingjian Zhu ◽

Yongqiang Zhang ◽

Zizhao Guo ◽

...

Keyword(s):

Small Molecule ◽

Protein Interaction ◽

Small Molecule Inhibitors ◽

Biological Evaluation ◽

Mdm2 Protein ◽

ChemInform Abstract: Synthesis and Biological Evaluation of Thio-benzodiazepines as Novel Small Molecule Inhibitors of the p53-MDM2 Protein-Protein Interaction.

ChemInform ◽

10.1002/chin.201212183 ◽

2012 ◽

Vol 43 (12) ◽

pp. no-no

Author(s):

Chunquan Sheng ◽

et al. et al.

Keyword(s):

Small Molecule ◽

Protein Interaction ◽

Small Molecule Inhibitors ◽

Biological Evaluation ◽

Mdm2 Protein ◽

Synthesis and Biological Evaluation of Novel Dispiro Compounds based on 5-Arylidenehydantoins and Isatins as Inhibitors of p53–MDM2 Protein–Protein Interaction

Chemistry of Heterocyclic Compounds ◽

10.1007/s10593-020-02726-0 ◽

2020 ◽

Vol 56 (6) ◽

pp. 747-755

Author(s):

Anastasia Beloglazkina ◽

Alexander Barashkin ◽

Vladislav Polyakov ◽

German Kotovsky ◽

Nikita Karpov ◽

...

Keyword(s):

Protein Interaction ◽

Biological Evaluation ◽

Mdm2 Protein ◽

Design, synthesis, and biological evaluation of novel FAK scaffold inhibitors targeting the FAK–VEGFR3 protein–protein interaction

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2014.04.041 ◽

2014 ◽

Vol 80 ◽

pp. 154-166 ◽

Cited By ~ 13

Author(s):

Priyanka N. Gogate ◽

Manivannan Ethirajan ◽

Elena V. Kurenova ◽

Andrew T. Magis ◽

Ravindra K. Pandey ◽

...

Keyword(s):

Protein Interaction ◽

Biological Evaluation ◽

Design Synthesis ◽

Abstract 3242: New chemical tools for disrupting the MDM2/p53 protein-protein interaction: Identification, synthesis and biological evaluation of a novel class of MDM2/p53 inhibitors

10.1158/1538-7445.am2011-3242 ◽

2011 ◽

Author(s):

Daniele Pernazza ◽

Xiaolong Li ◽

Harshani R. Lawrence ◽

Wayne C. Guida ◽

Courtney J. DuBoulay ◽

...

Keyword(s):

Protein Interaction ◽

P53 Protein ◽

Biological Evaluation ◽

Chemical Tools ◽

Abstract 828: Design, synthesis and biological evaluation of peptide inhibitors of the Keap1-Nrf2 protein-protein interaction

10.1158/1538-7445.am2011-828 ◽

2011 ◽

Author(s):

Rowena Hancock ◽

Helene Bertrand ◽

Shama Naz ◽

Tadayuki Tsujita ◽

John Hayes ◽

...

Keyword(s):

Protein Interaction ◽

Biological Evaluation ◽

Peptide Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Nrf2 Protein

Synthesis and biological evaluation of thielocin B1 analogues as protein-protein interaction inhibitors of PAC3 homodimer

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2018.11.001 ◽

2018 ◽

Vol 26 (23-24) ◽

pp. 6023-6034 ◽

Cited By ~ 1

Author(s):

Kosuke Ohsawa ◽

Masahito Yoshida ◽

Miho Izumikawa ◽

Motoki Takagi ◽

Kazuo Shin-ya ◽

...

Keyword(s):

Protein Interaction ◽

Biological Evaluation ◽

Discovery of novel dihydroimidazothiazole derivatives as p53–MDM2 protein–protein interaction inhibitors: Synthesis, biological evaluation and structure–activity relationships

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2012.08.086 ◽

2012 ◽

Vol 22 (20) ◽

pp. 6338-6342 ◽

Cited By ~ 13

Author(s):

Masaki Miyazaki ◽

Haruko Kawato ◽

Hiroyuki Naito ◽

Masahiro Ikeda ◽

Masaya Miyazaki ◽

...

Keyword(s):

Protein Interaction ◽

Biological Evaluation ◽

Mdm2 Protein ◽

Structure Activity Relationships ◽

Structure Activity

Synthesis and biological evaluation of novel antiviral agents as protein–protein interaction inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry ◽

10.3109/14756366.2013.766609 ◽

2013 ◽

Vol 29 (2) ◽

pp. 237-242 ◽

Cited By ~ 6

Author(s):

Stefania Ferro ◽

Laura De Luca ◽

Francesca Morreale ◽

Frauke Christ ◽

Zeger Debyser ◽

...

Keyword(s):

Protein Interaction ◽

Antiviral Agents ◽

Biological Evaluation ◽

Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c02188 ◽

2021 ◽

Author(s):

Gianni Chessari ◽

Ian R. Hardcastle ◽

Jong Sook Ahn ◽

Burcu Anil ◽

Elizabeth Anscombe ◽

...

Keyword(s):

Protein Interaction ◽

P53 Protein ◽

Orally Active