Tetrahydro-β-carboline derivatives targeting fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels

Trp Channels ◽

Acid Amide ◽

Receptor Potential ◽

Amide Hydrolase ◽

Transient Receptor ◽

The Blockade of the Transient Receptor Potential Vanilloid Type 1 and Fatty Acid Amide Hydrolase Decreases Symptoms and Central Sequelae in the Medial Prefrontal Cortex of Neuropathic Rats

Molecular Pain ◽

10.1186/1744-8069-7-7 ◽

2011 ◽

Vol 7 ◽

pp. 1744-8069-7-7 ◽

Cited By ~ 56

Author(s):

Vito de Novellis ◽

Daniela Vita ◽

Luisa Gatta ◽

Livio Luongo ◽

Giulia Bellini ◽

...

Keyword(s):

Fatty Acid ◽

Acid Amide ◽

Receptor Potential ◽

Amide Hydrolase ◽

Transient Receptor ◽

Piperazinyl carbamate fatty acid amide hydrolase inhibitors and transient receptor potential channel modulators as “dual-target” analgesics

Pharmacological Research ◽

10.1016/j.phrs.2013.07.003 ◽

2013 ◽

Vol 76 ◽

pp. 98-105 ◽

Cited By ~ 25

Author(s):

Sabatino Maione ◽

Barbara Costa ◽

Fabiana Piscitelli ◽

Enrico Morera ◽

Maria De Chiaro ◽

...

Keyword(s):

Fatty Acid ◽

Acid Amide ◽

Receptor Potential ◽

Transient Receptor Potential Channel ◽

Amide Hydrolase ◽

Transient Receptor ◽

Dual Target ◽

Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.09.033 ◽

2009 ◽

Vol 19 (23) ◽

pp. 6806-6809 ◽

Cited By ~ 22

Author(s):

Enrico Morera ◽

Luciano De Petrocellis ◽

Ludovica Morera ◽

Aniello Schiano Moriello ◽

Alessia Ligresti ◽

...

Keyword(s):

Fatty Acid ◽

Acid Amide ◽

Receptor Potential ◽

Biological Evaluation ◽

Amide Hydrolase ◽

Transient Receptor ◽

Synthesis And Biological Evaluation ◽

Anxiolytic Effects in Mice of a Dual Blocker of Fatty Acid Amide Hydrolase and Transient Receptor Potential Vanilloid Type-1 Channels

Neuropsychopharmacology ◽

10.1038/npp.2008.98 ◽

2008 ◽

Vol 34 (3) ◽

pp. 593-606 ◽

Cited By ~ 132

Author(s):

Vincenzo Micale ◽

Luigia Cristino ◽

Alessandra Tamburella ◽

Stefania Petrosino ◽

Gian Marco Leggio ◽

...

Keyword(s):

Fatty Acid ◽

Acid Amide ◽

Receptor Potential ◽

Amide Hydrolase ◽

Transient Receptor ◽

Targeting fatty acid amide hydrolase and transient receptor potential vanilloid-1 simultaneously to modulate colonic motility and visceral sensation in the mouse: A pharmacological intervention with N-arachidonoyl-serotonin (AA-5-HT)

Neurogastroenterology & Motility ◽

10.1111/nmo.13148 ◽

2017 ◽

Vol 29 (12) ◽

pp. e13148 ◽

Cited By ~ 7

Author(s):

M. Bashashati ◽

J. Fichna ◽

F. Piscitelli ◽

R. Capasso ◽

A. A. Izzo ◽

...

Keyword(s):

Colonic Motility ◽

Acid Amide ◽

Receptor Potential ◽

Pharmacological Intervention ◽

Visceral Sensation ◽

Amide Hydrolase ◽

Transient Receptor

Anticonvulsant Effects ofN-Arachidonoyl-Serotonin, a Dual Fatty Acid Amide Hydrolase Enzyme and Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Blocker, on Experimental Seizures: The Roles of Cannabinoid CB1 Receptors and TRPV1 Channels

Basic & Clinical Pharmacology & Toxicology ◽

10.1111/bcpt.12232 ◽

2014 ◽

Vol 115 (4) ◽

pp. 330-334 ◽

Cited By ~ 13

Author(s):

Luciano R. Vilela ◽

Daniel C. Medeiros ◽

Antonio Carlos P. de Oliveira ◽

Marcio F. Moraes ◽

Fabricio A. Moreira

Keyword(s):

Acid Amide ◽

Receptor Potential ◽

Trpv1 Channel ◽

Trpv1 Channels ◽

Amide Hydrolase ◽

Transient Receptor

Elevation of Endocannabinoid Levels in the Ventrolateral Periaqueductal Grey through Inhibition of Fatty Acid Amide Hydrolase Affects Descending Nociceptive Pathways via Both Cannabinoid Receptor Type 1 and Transient Receptor Potential Vanilloid Type-1 Receptors

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.105.093286 ◽

2005 ◽

Vol 316 (3) ◽

pp. 969-982 ◽

Cited By ~ 203

Author(s):

Sabatino Maione ◽

Tiziana Bisogno ◽

Vito de Novellis ◽

Enza Palazzo ◽

Luigia Cristino ◽

...

Keyword(s):

Cannabinoid Receptor ◽

Acid Amide ◽

Receptor Potential ◽

Nociceptive Pathways ◽

Amide Hydrolase ◽

Transient Receptor

Faculty Opinions recommendation of Inactivation of fatty acid amide hydrolase exacerbates experimental fibrosis by enhanced endocannabinoid-mediated activation of CB1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717956659.793461149 ◽

2012 ◽

Author(s):

Jaap van Laar ◽

Steven O'Reilly

Keyword(s):

Fatty Acid ◽

Acid Amide ◽

Amide Hydrolase ◽

Faculty of 1000 evaluation for An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee.

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.717965600.793466602 ◽

2012 ◽

Author(s):

Arun Bhaskar

Keyword(s):

Clinical Trial ◽

Fatty Acid ◽

Acid Amide ◽

Controlled Clinical Trial ◽

Osteoarthritis Of The Knee ◽

Amide Hydrolase ◽

Effective Analgesia ◽

Faculty Opinions recommendation of Elevated anandamide, enhanced recall of fear extinction, and attenuated stress responses following inhibition of fatty acid amide hydrolase: A randomized, controlled experimental medicine trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.736464037.793566019 ◽

2019 ◽

Author(s):

Yavin Shaham

Keyword(s):

Fatty Acid ◽

Stress Responses ◽

Acid Amide ◽

Fear Extinction ◽

Experimental Medicine ◽

Randomized Controlled ◽

Amide Hydrolase ◽