Structure–activity relationships (SAR) and structure–kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists III: The role of a hydrogen-bond acceptor in long receptor residence times

Structure Activity ◽

Acetic Acids

Structure-activity relationships in the acronycine and benzo[b]acronycine series: Role of the pyran ring

Planta Medica ◽

10.1055/s-0028-1084761 ◽

2008 ◽

Vol 74 (09) ◽

Author(s):

Q Do ◽

H Doan Thi Mai ◽

T Gaslonde ◽

B Pfeiffer ◽

S Léonce ◽

...

Keyword(s):

Pyran Ring ◽

Structure-activity relationships of interleukin-8 determined using chemically synthesized analogs. Critical role of NH2-terminal residues and evidence for uncoupling of neutrophil chemotaxis, exocytosis, and receptor binding activities.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)54472-0 ◽

1991 ◽

Vol 266 (34) ◽

pp. 23128-23134 ◽

Cited By ~ 6

Author(s):

I. Clark-Lewis ◽

C. Schumacher ◽

M. Baggiolini ◽

B. Moser

Keyword(s):

Receptor Binding ◽

Critical Role ◽

Interleukin 8 ◽

Neutrophil Chemotaxis ◽

On the potential role of the amino nitrogen atom as a hydrogen bond acceptor in macromolecules

Journal of Molecular Biology ◽

10.1006/jmbi.1998.1833 ◽

1998 ◽

Vol 279 (5) ◽

pp. 1123-1136 ◽

Cited By ~ 57

Author(s):

Ben Luisi ◽

Modesto Orozco ◽

Jiri Sponer ◽

Francisco J Luque ◽

Zippora Shakked

Keyword(s):

Hydrogen Bond ◽

Nitrogen Atom ◽

Potential Role ◽

Amino Nitrogen ◽

Hydrogen Bond Acceptor ◽

Amino Nitrogen Atom

Structure-Activity Relationships Among the Aminoglycoside Antibiotics: Role of Hydroxyl and Amino Groups

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.4.4.402 ◽

1973 ◽

Vol 4 (4) ◽

pp. 402-409 ◽

Cited By ~ 69

Author(s):

R. Benveniste ◽

J. Davies

Keyword(s):

Aminoglycoside Antibiotics ◽

Amino Groups ◽

Structure−Activity Relationships of Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone. 2. Role of the Substituents on the Phenyl Ring and Nitrogen Atoms of Caproctamine

Journal of Medicinal Chemistry ◽

10.1021/jm021055+ ◽

2003 ◽

Vol 46 (6) ◽

pp. 954-966 ◽

Cited By ~ 20

Author(s):

Vincenzo Tumiatti ◽

Michela Rosini ◽

Manuela Bartolini ◽

Andrea Cavalli ◽

Gabriella Marucci ◽

...

Keyword(s):

Phenyl Ring ◽

Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use

Bone ◽

10.1016/j.bone.2021.116289 ◽

2021 ◽

pp. 116289

Author(s):

Frank H. Ebetino ◽

Shuting Sun ◽

Philip Cherian ◽

Sahar Roshandel ◽

Jeffrey D. Neighbors ◽

...

Keyword(s):

Therapeutic Use ◽

Structure Activity ◽

New Directions ◽

Biological Actions

Structure-activity relationships of neuropeptide FF: role of C-terminal regions

Peptides ◽

10.1016/s0196-9781(01)00468-5 ◽

2001 ◽

Vol 22 (9) ◽

pp. 1471-1478 ◽

Cited By ~ 53

Author(s):

Honoré Mazarguil ◽

Christine Gouardères ◽

Jean-André M. Tafani ◽

Delphine Marcus ◽

Masato Kotani ◽

...

Keyword(s):

Structure Activity ◽

Neuropeptide Ff

The role of ligand flexibility in predicting biological activity: Structure-activity relationships for aryl hydrocarbon, estrogen, and androgen receptor binding affinity

Environmental Toxicology and Chemistry ◽

10.1002/etc.5620170103 ◽

1998 ◽

Vol 17 (1) ◽

pp. 15-25 ◽

Cited By ~ 2

Author(s):

Steven P. Bradbury ◽

Ovanes G. Mekenyan ◽

Gerald T. Ankley

Keyword(s):

Biological Activity ◽

Androgen Receptor ◽

Binding Affinity ◽

Receptor Binding ◽

Receptor Binding Affinity ◽

Aryl Hydrocarbon ◽

Structure Activity ◽

Activity Structure

Peptide Dendrimer/Lipid Hybrid Systems Are Efficient DNA Transfection Reagents: Structure–Activity Relationships Highlight the Role of Charge Distribution Across Dendrimer Generations

ACS Nano ◽

10.1021/nn400343z ◽

2013 ◽

Vol 7 (5) ◽

pp. 4668-4682 ◽

Cited By ~ 62

Author(s):

Albert Kwok ◽

Gabriela A. Eggimann ◽

Jean-Louis Reymond ◽

Tamis Darbre ◽

Florian Hollfelder

Keyword(s):

Hybrid Systems ◽

Charge Distribution ◽

Dna Transfection ◽

Structure Activity ◽

Peptide Dendrimer

Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 2. On the role of correlation analysis in decision making in drug modification. Toxicity quantitative structure-activity relationships of 1-(X-phenyl)-3,3-dialkyltriazenes in mice

Journal of Medicinal Chemistry ◽

10.1021/jm00204a013 ◽

1978 ◽

Vol 21 (6) ◽

pp. 574-577 ◽

Cited By ~ 28

Author(s):

Corwin Hansch ◽

Gerard J. Hatheway ◽

Frank R. Quinn ◽

Nathaniel Greenberg

Keyword(s):

Decision Making ◽

Correlation Analysis ◽

Quantitative Structure ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Drug Modification