Identification and characterization of potent and selective inhibitors targeting protein tyrosine phosphatase 1B (PTP1B)

Tyrosine Phosphatase ◽

Identification And Characterization

Selective Inhibitors ◽

Protein Tyrosine ◽

Design, synthesis, kinetic, molecular dynamics, and hypoglycemic effect characterization of new and potential selective benzimidazole derivatives as Protein Tyrosine Phosphatase 1B inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2021.116418 ◽

2021 ◽

pp. 116418

Author(s):

Mara Ibeth Campos-Almazán ◽

Miguel Flores-Ramos ◽

Alicia Hernández-Campos ◽

Rafael Castillo ◽

Erick Sierra-Campos ◽

...

Keyword(s):

Molecular Dynamics ◽

Tyrosine Phosphatase ◽

Hypoglycemic Effect ◽

Benzimidazole Derivatives ◽

Design Synthesis ◽

Characterization of active compounds from Gracilaria lemaneiformis inhibiting the protein tyrosine phosphatase 1B activity

Food & Function ◽

10.1039/c7fo00376e ◽

2017 ◽

Vol 8 (9) ◽

pp. 3271-3275 ◽

Cited By ~ 12

Author(s):

Xinfeng Guo ◽

Dongyu Gu ◽

Miao Wang ◽

Yu Huang ◽

Haoquan Li ◽

...

Keyword(s):

Tyrosine Phosphatase ◽

Gracilaria Lemaneiformis ◽

Active Compounds ◽

Gracilaria lemaneiformis, an edible alga, with various bioactivities is a traditional dish and a favorite food.

Characterization of the inhibitory activity of natural tanshinones from Salvia miltiorrhiza roots on protein tyrosine phosphatase 1B

Chemico-Biological Interactions ◽

10.1016/j.cbi.2017.10.013 ◽

2017 ◽

Vol 278 ◽

pp. 65-73 ◽

Cited By ~ 10

Author(s):

Da Hye Kim ◽

Pradeep Paudel ◽

Ting Yu ◽

Thi Men Ngo ◽

Jeong Ah Kim ◽

...

Keyword(s):

Inhibitory Activity ◽

Salvia Miltiorrhiza ◽

Tyrosine Phosphatase ◽

Genomic characterization of the human and mouse protein tyrosine phosphatase-1B genes

Gene ◽

10.1016/s0378-1119(00)00464-9 ◽

2000 ◽

Vol 260 (1-2) ◽

pp. 145-153 ◽

Cited By ~ 29

Author(s):

PontusK.A.L. Forsell ◽

Yves Boie ◽

Jacqueline Montalibet ◽

Susan Collins ◽

Brian P. Kennedy

Keyword(s):

Tyrosine Phosphatase ◽

Protein Tyrosine ◽

Mouse Protein ◽

Genomic Characterization ◽

Human And Mouse

Formylchromone derivatives as irreversible and selective inhibitors of human protein tyrosine phosphatase 1B. Kinetic and modeling studies

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2004.11.006 ◽

2005 ◽

Vol 13 (4) ◽

pp. 1325-1332 ◽

Cited By ~ 27

Author(s):

Yi Sup Shim ◽

Ki Chul Kim ◽

Kyung A. Lee ◽

Suja Shrestha ◽

Keun-Hyeung Lee ◽

...

Keyword(s):

Tyrosine Phosphatase ◽

Human Protein ◽

Selective Inhibitors ◽

Protein Tyrosine ◽

Modeling Studies

Structural, kinetic and biochemical characterization of the oxidation states of human protein tyrosine phosphatase 1B: implications for redox regulation of phosphatase activity

Acta Crystallographica Section A Foundations of Crystallography ◽

10.1107/s0108767302096277 ◽

2002 ◽

Vol 58 (s1) ◽

pp. c282-c282

Author(s):

C. Abad-Zapatero ◽

T. Lubben ◽

J. Severin ◽

E. Hebert ◽

T. Ahmed ◽

...

Keyword(s):

Phosphatase Activity ◽

Redox Regulation ◽

Biochemical Characterization ◽

Tyrosine Phosphatase ◽

Human Protein ◽

Oxidation States ◽

Discovery of novel and selective inhibitors targeting protein tyrosine phosphatase 1B (PTP1B): Virtual screening and molecular dynamic simulation

Computers in Biology and Medicine ◽

10.1016/j.compbiomed.2021.104959 ◽

2021 ◽

pp. 104959

Author(s):

Kubra Akyol ◽

Deryanur Kilic

Keyword(s):

Virtual Screening ◽

Molecular Dynamic Simulation ◽

Molecular Dynamic ◽

Dynamic Simulation ◽

Tyrosine Phosphatase ◽

Selective Inhibitors ◽

Potent, selective inhibitors of protein tyrosine phosphatase 1B

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(03)00302-0 ◽

2003 ◽

Vol 13 (11) ◽

pp. 1887-1890 ◽

Cited By ~ 34

Author(s):

Zhili Xin ◽

Thorsten K Oost ◽

Cele Abad-Zapatero ◽

Philip J Hajduk ◽

Zhonghua Pei ◽

...

Keyword(s):

Tyrosine Phosphatase ◽

Selective Inhibitors ◽

Synthesis and characterization of 5,7-dihydroxyflavanone derivatives as novel protein tyrosine phosphatase 1B inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry ◽

10.3109/14756366.2012.723206 ◽

2012 ◽

Vol 28 (6) ◽

pp. 1199-1204 ◽

Cited By ~ 6

Author(s):

Liang-Peng Sun ◽

Wei-Ping Ma ◽

Li-Xin Gao ◽

Ling-Ling Yang ◽

Ying-Chun Quan ◽

...

Keyword(s):

Tyrosine Phosphatase ◽

Synthesis And Characterization ◽

Protein Tyrosine ◽

Novel Protein

Identification and Characterization of a Protein-tyrosine Phosphatase inLeishmania

Journal of Biological Chemistry ◽

10.1074/jbc.m606256200 ◽

2006 ◽

Vol 281 (47) ◽

pp. 36257-36268 ◽

Cited By ~ 26

Author(s):

Mirna Nascimento ◽

Wen-Wei Zhang ◽

Anirban Ghosh ◽

Douglas R. Houston ◽

Albert M. Berghuis ◽

...

Keyword(s):

Identification And Characterization

Tyrosine Phosphatase ◽

Protein Tyrosine ◽