Discovery and pharmacological evaluation of indole derivatives as potent and selective RORγt inverse agonist for multiple autoimmune conditions

2019 ◽  
Vol 29 (16) ◽  
pp. 2208-2217 ◽  
Author(s):  
Nadim S. Shaikh ◽  
Jitesh P. Iyer ◽  
Yogesh S. Munot ◽  
Partha P. Mukhopadhyay ◽  
Amol A. Raje ◽  
...  
Keyword(s):  
Inverse Agonist ◽  
Indole Derivatives ◽  
Pharmacological Evaluation ◽  
Autoimmune Conditions

scholarly journals Synthesis and Pharmacological Evaluation of Indole Derivatives as Deaza Analogues of Potent Human Neutrophil Elastase Inhibitors

2016 ◽  
Vol 77 (6) ◽  
pp. 285-299 ◽  
Author(s):  
Letizia Crocetti ◽  
Igor A. Schepetkin ◽  
Giovanna Ciciani ◽  
Maria Paola Giovannoni ◽  
Gabriella Guerrini ◽  
...  
Keyword(s):  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Human Neutrophil Elastase ◽  
Indole Derivatives ◽  
Pharmacological Evaluation

Synthesis and pharmacological evaluation of new indole derivatives structurally related to thymoxamine

1994 ◽  
Vol 29 (7-8) ◽  
pp. 551-559 ◽  
Author(s):  
A Leonardi ◽  
C Riva ◽  
C De Toma ◽  
C Boi ◽  
R Pennini ◽  
...  
Keyword(s):  
Indole Derivatives ◽  
Pharmacological Evaluation

Design, synthesis and pharmacological evaluation of 4-(piperazin-1-yl methyl)-N1-arylsulfonyl indole derivatives as 5-HT6 receptor ligands

2012 ◽  
Vol 22 (24) ◽  
pp. 7431-7435 ◽  
Author(s):  
Ramakrishna V.S. Nirogi ◽  
Rajeshkumar Badange ◽  
Ramasastri Kambhampati ◽  
Anil Chindhe ◽  
Amol D. Deshpande ◽  
...  
Keyword(s):  
Indole Derivatives ◽  
Receptor Ligands ◽  
Design Synthesis ◽  
Pharmacological Evaluation

ChemInform Abstract: Synthesis and Pharmacological Evaluation of New Indole Derivatives Structurally Related to Thymoxamine.

ChemInform ◽  
2010 ◽  
Vol 26 (2) ◽  
pp. no-no
Author(s):  
A. LEONARDI ◽  
C. RIVA ◽  
C. DE TOMA ◽  
C. BOI ◽  
R. PENNINI ◽  
...  
Keyword(s):  
Indole Derivatives ◽  
Pharmacological Evaluation

Pharmacological Evaluation of TAK-828F, a Novel Orally Available RORγt Inverse Agonist, on Murine Colitis Model

Inflammation ◽  
2018 ◽  
Vol 42 (1) ◽  
pp. 91-102 ◽  
Author(s):  
Keiko Igaki ◽  
Yoshiki Nakamura ◽  
Yusaku Komoike ◽  
Keiko Uga ◽  
Akira Shibata ◽  
...  
Keyword(s):  
Inverse Agonist ◽  
Murine Colitis ◽  
Pharmacological Evaluation ◽  
Colitis Model

Ultrasound assisted rapid synthesis of mefenamic acid based indole derivatives under ligand free Cu-catalysis: Their pharmacological evaluation

2020 ◽  
Vol 30 (10) ◽  
pp. 127112
Author(s):  
Rapolu Venkateshwarlu ◽  
Shambhu Nath Singh ◽  
Vidavalur Siddaiah ◽  
Hindupur Ramamohan ◽  
Rambabu Dandela ◽  
...  
Keyword(s):  
Mefenamic Acid ◽  
Indole Derivatives ◽  
Rapid Synthesis ◽  
Pharmacological Evaluation ◽  
Ligand Free ◽  
Ultrasound Assisted

Catalytic enantioselective synthesis of indolizino[8,7-b]indole alkaloid derivatives based on the tandem reaction of tertiary enamides

2021 ◽  
Author(s):  
Xin-Ming Xu ◽  
Ming Xie ◽  
Jiazhu Li ◽  
Mei-Xiang Wang
Keyword(s):  
Indole Alkaloid ◽  
Enantioselective Synthesis ◽  
High Yield ◽  
Tandem Reaction ◽  
Indole Derivatives

An exquisite Pybox/Cu(OTf)2-catalyzed asymmetric tandem reaction of tertiary enamides was developed, which enabled the expeditious synthesis of indolizino[8,7-b]indole derivatives in high yield, excellent enantioselectivity and diastereoselectivity.

Pharmacological Evaluation of Novel Flavone from Morus alba in Pentylenetetrazole-Induced Kindling and Oxidative Stress

2018 ◽  
Vol 37 (1) ◽  
pp. 43-52 ◽  
Author(s):  
Bin Wang ◽  
Gaurav Gupta ◽  
Mahaveer Singh ◽  
Kasturi Vishwanatha Setty Veerabhadrappa ◽  
Anurag Mishra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Morus Alba ◽  
Pharmacological Evaluation ◽  
And Oxidative Stress
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