Design, synthesis and mechanistic studies of a TICT based fluorogenic probe for lighting up protein HSA

2021 ◽  
pp. 128438
Author(s):  
Yang Luo ◽  
Quan-Qi Yu ◽  
Juan-Juan Gao ◽  
Xue-Xian Lang ◽  
Hong-Yao Li ◽  
...  
Keyword(s):  
Mechanistic Studies ◽  
Design Synthesis ◽  
Fluorogenic Probe

Design, synthesis, mechanistic studies and in silico ADME predictions of benzimidazole derivatives as novel antifungal agents

2020 ◽  
Vol 101 ◽  
pp. 103956 ◽  
Author(s):  
Martha M. Morcoss ◽  
El Shimaa M.N. Abdelhafez ◽  
Reham A. Ibrahem ◽  
Hamdy M. Abdel-Rahman ◽  
Mohamed Abdel-Aziz ◽  
...  
Keyword(s):  
In Silico ◽  
Antifungal Agents ◽  
Benzimidazole Derivatives ◽  
Mechanistic Studies ◽  
Design Synthesis

scholarly journals Enone– and Chalcone–Chloroquinoline Hybrid Analogues: In Silico Guided Design, Synthesis, Antiplasmodial Activity, in Vitro Metabolism, and Mechanistic Studies

2011 ◽  
Vol 54 (10) ◽  
pp. 3637-3649 ◽  
Author(s):  
Eric M. Guantai ◽  
Kanyile Ncokazi ◽  
Timothy J. Egan ◽  
Jiri Gut ◽  
Philip J. Rosenthal ◽  
...  
Keyword(s):  
In Silico ◽  
In Vitro Metabolism ◽  
Antiplasmodial Activity ◽  
Mechanistic Studies ◽  
Design Synthesis

Chiral and Regenerable NAD(P)H Models Enabled Biomimetic Asymmetric Reduction: Design, Synthesis, Scope, and Mechanistic Studies

2019 ◽  
Vol 85 (4) ◽  
pp. 2355-2368 ◽  
Author(s):  
Jie Wang ◽  
Zi-Biao Zhao ◽  
Yanan Zhao ◽  
Gen Luo ◽  
Zhou-Hao Zhu ◽  
...  
Keyword(s):  
Asymmetric Reduction ◽  
Mechanistic Studies ◽  
Design Synthesis

scholarly journals Design, synthesis and application of fluorogenic probe for detecting l-asparaginase in serum samples

2021 ◽  
Vol 3 ◽  
pp. 100103
Author(s):  
Lan Wang ◽  
Wenjing Qin ◽  
Ding Chen ◽  
Nanxiang Wang ◽  
Congcong Zhang ◽  
...  
Keyword(s):  
Serum Samples ◽  
Design Synthesis ◽  
Fluorogenic Probe

Novel 1,2,4-triazole derivatives as potential anticancer agents: Design, synthesis, molecular docking and mechanistic studies

2018 ◽  
Vol 76 ◽  
pp. 314-325 ◽  
Author(s):  
Hany A.M. El-Sherief ◽  
Bahaa G.M. Youssif ◽  
Syed Nasir Abbas Bukhari ◽  
Mohamed Abdel-Aziz ◽  
Hamdy M. Abdel-Rahman
Keyword(s):  
Molecular Docking ◽  
Anticancer Agents ◽  
Mechanistic Studies ◽  
Design Synthesis ◽  
Triazole Derivatives

A GGCT fluorogenic probe: design, synthesis and application to cancer-related cells

2015 ◽  
Vol 13 (11) ◽  
pp. 3182-3185 ◽  
Author(s):  
Taku Yoshiya ◽  
Hiromi Ii ◽  
Shugo Tsuda ◽  
Susumu Kageyama ◽  
Tatsuhiro Yoshiki ◽  
...  
Keyword(s):  
Amino Acids ◽  
Probe Design ◽  
Design Synthesis ◽  
Fluorogenic Probe

Cancer-related γ-glutamyl cyclotransferase (GGCT) specifically decomposes γ-glutamyl amino acids. Here we report a novel GGCT fluorogenic probe “LISA-101”.

scholarly journals Antitumor Agents 268. Design, Synthesis, and Mechanistic Studies of New 9-Substituted Phenanthrene-Based Tylophorine Analogues as Potent Cytotoxic Agents

2009 ◽  
Vol 52 (16) ◽  
pp. 5262-5268 ◽  
Author(s):  
Xiaoming Yang ◽  
Qian Shi ◽  
Yi-Nan Liu ◽  
Guiyu Zhao ◽  
Kenneth F. Bastow ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Cytotoxic Agents ◽  
Mechanistic Studies ◽  
Design Synthesis

Design, synthesis and anticancer mechanistic studies of linked azoles

MedChemComm ◽  
2015 ◽  
Vol 6 (2) ◽  
pp. 300-305 ◽  
Author(s):  
Md. Amirul Islam ◽  
Yuqi Zhang ◽  
Yao Wang ◽  
Shelli R. McAlpine
Keyword(s):  
Biological Activity ◽  
Mechanistic Studies ◽  
Design Synthesis ◽  
Activity Evaluation

Herein we report the synthesis and biological activity evaluation of 2,4 linked azole-containing molecules.

scholarly journals Antitumor Agents 295. E-Ring Hydroxylated Antofine and Cryptopleurine Analogues as Antiproliferative Agents: Design, Synthesis, and Mechanistic Studies

2012 ◽  
Vol 55 (15) ◽  
pp. 6751-6761 ◽  
Author(s):  
Xiaoming Yang ◽  
Qian Shi ◽  
Chin-Yu Lai ◽  
Chi-Yuan Chen ◽  
Emika Ohkoshi ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Mechanistic Studies ◽  
Design Synthesis ◽  
Antiproliferative Agents

Design, Synthesis and Anticancer Evaluation of Carbazole Fused Aminopyrimidine Derivatives

2019 ◽  
Vol 16 (8) ◽  
pp. 662-667 ◽  
Author(s):  
Zanjam Spandana ◽  
Reddymasu Sreenivasulu ◽  
Mandava V. Basaveswara Rao
Keyword(s):  
Biological Activities ◽  
Coal Tar ◽  
Cancer Cell Line ◽  
Moderate Activity ◽  
Good Activity ◽  
Mechanistic Studies ◽  
Pharmacological Activities ◽  
Design Synthesis ◽  
Carbazole Alkaloids ◽  
Mcf 7

Carbazole is an important type of tricyclic nitrogen containing compound and isolated first from coal tar in 1872 by Graebe and Glazer. Carbazole alkaloids have received considerable attention since their discovery in the 1960’s and their derivatives are well known for their pharmacological activities. Many recent studies have reported that carbazole derivatives exhibit a variety of biological activities. Toxicity of test compound in cells was determined by MTT assay based on mitochondrial reduction of yellow MTT tetrazolium dye to a highly blue colored formazan product. Among the ten synthesized compounds, 12c, 12d, 12e, 12f, 12g and 12i were showed good activity. In which 12c, 12d and 12e showed moderate activity on MCF-7 cancer cell line. Compounds 12f, 12g and 12i showed more potent activity than control. Compounds 12f, 12g and 12i showed more potent activity than control adriamycin. In future, we will plan further mechanistic studies on most potent active compounds 12f, 12g and 12i.

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