scholarly journals Antitumor Agents 295. E-Ring Hydroxylated Antofine and Cryptopleurine Analogues as Antiproliferative Agents: Design, Synthesis, and Mechanistic Studies

2012 ◽  
Vol 55 (15) ◽  
pp. 6751-6761 ◽  
Author(s):  
Xiaoming Yang ◽  
Qian Shi ◽  
Chin-Yu Lai ◽  
Chi-Yuan Chen ◽  
Emika Ohkoshi ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Mechanistic Studies ◽  
Design Synthesis ◽  
Antiproliferative Agents

scholarly journals Antitumor Agents 268. Design, Synthesis, and Mechanistic Studies of New 9-Substituted Phenanthrene-Based Tylophorine Analogues as Potent Cytotoxic Agents

2009 ◽  
Vol 52 (16) ◽  
pp. 5262-5268 ◽  
Author(s):  
Xiaoming Yang ◽  
Qian Shi ◽  
Yi-Nan Liu ◽  
Guiyu Zhao ◽  
Kenneth F. Bastow ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Cytotoxic Agents ◽  
Mechanistic Studies ◽  
Design Synthesis

Design, Synthesis of Novel Quinazolone Alkaloids Derivatives as Potential Antitumor Agents

2011 ◽  
Vol 7 (4) ◽  
pp. 295-300
Author(s):  
Youguang Zheng ◽  
Min Sun ◽  
Yi Liu ◽  
Mingdong Li ◽  
Min Ji
Keyword(s):  
Antitumor Agents ◽  
Design Synthesis ◽  
Potential Antitumor

Naphthoflavones as Antiproliferative Agents: Design, Synthesis and Biological Evaluation

2016 ◽  
Vol 16 (7) ◽  
pp. 881-890 ◽  
Author(s):  
Dinesh Kumar ◽  
Onkar Singh ◽  
Kunal Nepali ◽  
PMS Bedi ◽  
Arem Qayum ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Antiproliferative Agents ◽  
Synthesis And Biological Evaluation

scholarly journals Design, Synthesis, and Antitumor Activity of Olmutinib Derivatives Containing Acrylamide Moiety

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 3041
Author(s):  
Xiaohan Hu ◽  
Sheng Tang ◽  
Feiyi Yang ◽  
Pengwu Zheng ◽  
Shan Xu ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antitumor Agents ◽  
Cancer Cell Lines ◽  
Design Synthesis ◽  
Structure Activity ◽  
Excellent Activity ◽  
Ic50 Values ◽  
Mcf 7

Two series of olmutinib derivatives containing an acrylamide moiety were designed and synthesized, and their IC50 values against cancer cell lines (A549, H1975, NCI-H460, LO2, and MCF-7) were evaluated. Most of the compounds exhibited moderate cytotoxic activity against the five cancer cell lines. The most promising compound, H10, showed not only excellent activity against EGFR kinase but also positive biological activity against PI3K kinase. The structure–activity relationship (SAR) suggested that the introduction of dimethylamine scaffolds with smaller spatial structures was more favorable for antitumor activity. Additionally, the substitution of different acrylamide side chains had different effects on the activity of compounds. Generally, compounds H7 and H10 were confirmed as promising antitumor agents.

1-Methyl-3H-pyrazolo[1,2-a]benzo[1,2,3,4]tetrazin-3-ones. Design, Synthesis, and Biological Activity of New Antitumor Agents

2005 ◽  
Vol 48 (8) ◽  
pp. 2859-2866 ◽  
Author(s):  
Anna Maria Almerico ◽  
Francesco Mingoia ◽  
Patrizia Diana ◽  
Paola Barraja ◽  
Antonino Lauria ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antitumor Agents ◽  
Design Synthesis

scholarly journals Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents

2015 ◽  
Vol 58 (19) ◽  
pp. 7749-7762 ◽  
Author(s):  
Yongseok Kwon ◽  
Jayoung Song ◽  
Honggu Lee ◽  
Eun-Yeong Kim ◽  
Kiho Lee ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antitumor Agents ◽  
Design Synthesis ◽  
Orally Active

ChemInform Abstract: Antitumor Agents. Part 202. Novel 2′-Amino Chalcones: Design, Synthesis, and Biological Evaluation.

ChemInform ◽  
2010 ◽  
Vol 31 (29) ◽  
pp. no-no
Author(s):  
Yi Xia ◽  
Zheng-Yu Yang ◽  
Peng Xia ◽  
Kenneth F. Bastow ◽  
Yuka Nakanishi ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

ChemInform Abstract: Design, Synthesis, and Biological Testing of 4β-[(4-Substituted)-1,2,3-triazol-1-yl]podophyllotoxin Analogues as Antitumor Agents.

ChemInform ◽  
2008 ◽  
Vol 39 (22) ◽  
Author(s):  
Pitta B. Reddy ◽  
David V. Paul ◽  
Satyam K. Agrawal ◽  
Ajit K. Saxena ◽  
Halmuthur M. S. Kumar ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Biological Testing ◽  
Design Synthesis
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