Efficacy, tolerability and safety of once-monthly administration of 75mg risedronate in Japanese patients with involutional osteoporosis: A comparison with a 2.5mg once-daily dosage regimen

A new potent topical corticosteroid, fluticasone propionate aqueous nasal spray, has proved effective when administered twice daily for seasonal allergic rhinitis. The purpose of this study was to compare the efficacy and safety of a once-daily dosage with twice-daily administration of fluticasone propionate. A multicenter, double-blind, randomized, placebo-controlled study was conducted in adults with moderate to severe symptoms of allergic rhinitis during the autumn pollen season. Patients were treated for 4 weeks with fluticasone propionate aqueous nasal spray, 200 μg once daily or 100 μg twice daily or matching placebo. Fluticasone propionate administered once daily in the morning was as effective as the twice-daily dosage regimen, and both regimens were more effective than placebo. Nasal symptoms were improved by the second day of treatment and continued to improve throughout the study. Nasal eosinophils were reduced in more patients treated with either regimen of fluticasone propionate compared with placebo. Adverse events were similar in frequency and nature in all three groups. There was no evidence of hypothalamicpituitary-adrenal axis effects; mean morning plasma cortisol concentrations and response to cosyntropin stimulation remained within normal ranges and were similar across groups. We conclude that fluticasone propionate aqueous nasal spray administered once daily is safe and as effective as a twice-daily dosage regimen for treating seasonal allergic rhinitis.

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Efficacy and safety of once-daily, single-inhaler fluticasone furoate/umeclidinium/vilanterol versus fluticasone furoate/vilanterol in Japanese patients with inadequately controlled asthma: the CAPTAIN study

Current Medical Research and Opinion ◽

10.1080/03007995.2021.1944849 ◽

2021 ◽

pp. 1-1

Author(s):

Yoichi Nakamura ◽

Soichiro Hozawa ◽

Hironori Sagara ◽

Hiroyuki Ohbayashi ◽

Laurie A. Lee ◽

...

Keyword(s):

Japanese Patients ◽

Efficacy And Safety ◽

Fluticasone Furoate ◽

Once Daily

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A comparison of incidences of vertebral fracture in Japanese patients with involutional osteoporosis treated with risedronate and etidronate: a randomized, double-masked trial

Journal of Bone and Mineral Metabolism ◽

10.1007/s00774-004-0509-z ◽

2004 ◽

Vol 22 (5) ◽

Cited By ~ 9

Author(s):

Kazuhiro Kushida ◽

Masao Fukunaga ◽

Hideaki Kishimoto ◽

Masataka Shiraki ◽

Akira Itabashi ◽

...

Keyword(s):

Vertebral Fracture ◽

Japanese Patients ◽

Involutional Osteoporosis

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The once-daily human glucagon-like peptide-1 analog, liraglutide, improves β-cell function in Japanese patients with type 2 diabetes

Journal of Diabetes Investigation ◽

10.1111/j.2040-1124.2012.00193.x ◽

2012 ◽

Vol 3 (4) ◽

pp. 388-395 ◽

Cited By ~ 9

Author(s):

Yutaka Seino ◽

Mads Frederik Rasmussen ◽

Per Clauson ◽

Kohei Kaku

Keyword(s):

Type 2 Diabetes ◽

Cell Function ◽

Japanese Patients ◽

Β Cell ◽

Once Daily ◽

Β Cell Function ◽

Glucagon Like Peptide ◽

Glucagon Like Peptide 1

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Effects of once-daily teneligliptin on 24-h blood glucose control and safety in Japanese patients with type 2 diabetes mellitus: a 4-week, randomized, double-blind, placebo-controlled trial

Diabetes Obesity and Metabolism ◽

10.1111/j.1463-1326.2012.01662.x ◽

2012 ◽

Vol 14 (11) ◽

pp. 1040-1046 ◽

Cited By ~ 51

Author(s):

T. Eto ◽

S. Inoue ◽

T. Kadowaki

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Controlled Trial ◽

Blood Glucose Control ◽

Japanese Patients ◽

Double Blind ◽

Once Daily ◽

Double Blind Placebo

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The Phase III, double-blind, parallel-group controlled study of amlodipine 10 mg once daily in Japanese patients with essential hypertension who insufficiently responded to amlodipine 5 mg once daily

Journal of Human Hypertension ◽

10.1038/jhh.2008.161 ◽

2009 ◽

Vol 23 (8) ◽

pp. 521-529 ◽

Cited By ~ 6

Author(s):

T Fujiwara ◽

Y Ii ◽

J Hatsuzawa ◽

H Murase ◽

T Watanabe ◽

...

Keyword(s):

Essential Hypertension ◽

Japanese Patients ◽

Phase Iii ◽

Controlled Study ◽

Double Blind ◽

Once Daily ◽

Parallel Group

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A Double-Blind Comparison of Three Times Daily and Single Night Dosage of the Tricyclic Anti-Depressant Dothiepin

Journal of International Medical Research ◽

10.1177/030006057400200103 ◽

1974 ◽

Vol 2 (1) ◽

pp. 12-19 ◽

Cited By ~ 18

Author(s):

J B Pearce ◽

W Linford Rees

Keyword(s):

Single Dose ◽

Dosage Regimen ◽

Trial Design ◽

Double Blind Trial ◽

Double Blind ◽

Matching Placebo ◽

Symptoms Of Depression ◽

Daily Dosage Regimen ◽

Single Night ◽

Blind Comparison

The study here presented was designed to evaluate the advantages of a once a day dosage of tricyclic anti-depressants as against a thrice daily dosage regimen using dothiepin (Prothiaden) and matching placebo capsules in a group comparative double-blind trial design. A total of sixty-two patients were admitted to the trial and were randomly allocated to one or other of the dosage regimes. Patients were assessed weekly for five weeks. More favourable results were achieved with patients taking the single dose nocturnally which was well tolerated in addition to being effective in relieving symptoms of depression. A number of possible advantages of this method of administration are discussed.

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