scholarly journals Efficacy, tolerability and safety of once-monthly administration of 75mg risedronate in Japanese patients with involutional osteoporosis: A comparison with a 2.5mg once-daily dosage regimen

Bone ◽  
2014 ◽  
Vol 59 ◽  
pp. 44-52 ◽  
Author(s):  
Hiroshi Hagino ◽  
Hideaki Kishimoto ◽  
Hiroaki Ohishi ◽  
Sayako Horii ◽  
Toshitaka Nakamura
1999 ◽  
Vol 21 (5) ◽  
pp. 514 ◽  
Author(s):  
Mees L. Vervelde ◽  
Carin M. A. Rademaker ◽  
Tannette G. Krediet ◽  
André Fleer ◽  
Paul van Asten ◽  
...  

1993 ◽  
Vol 7 (2) ◽  
pp. 77-83 ◽  
Author(s):  
Robert J. Dockhorn ◽  
Barry R. Paull ◽  
Eli O. Meltzer ◽  
Andre van As ◽  
Suzanne Weakley ◽  
...  

A new potent topical corticosteroid, fluticasone propionate aqueous nasal spray, has proved effective when administered twice daily for seasonal allergic rhinitis. The purpose of this study was to compare the efficacy and safety of a once-daily dosage with twice-daily administration of fluticasone propionate. A multicenter, double-blind, randomized, placebo-controlled study was conducted in adults with moderate to severe symptoms of allergic rhinitis during the autumn pollen season. Patients were treated for 4 weeks with fluticasone propionate aqueous nasal spray, 200 μg once daily or 100 μg twice daily or matching placebo. Fluticasone propionate administered once daily in the morning was as effective as the twice-daily dosage regimen, and both regimens were more effective than placebo. Nasal symptoms were improved by the second day of treatment and continued to improve throughout the study. Nasal eosinophils were reduced in more patients treated with either regimen of fluticasone propionate compared with placebo. Adverse events were similar in frequency and nature in all three groups. There was no evidence of hypothalamicpituitary-adrenal axis effects; mean morning plasma cortisol concentrations and response to cosyntropin stimulation remained within normal ranges and were similar across groups. We conclude that fluticasone propionate aqueous nasal spray administered once daily is safe and as effective as a twice-daily dosage regimen for treating seasonal allergic rhinitis.


1974 ◽  
Vol 2 (1) ◽  
pp. 12-19 ◽  
Author(s):  
J B Pearce ◽  
W Linford Rees

The study here presented was designed to evaluate the advantages of a once a day dosage of tricyclic anti-depressants as against a thrice daily dosage regimen using dothiepin (Prothiaden) and matching placebo capsules in a group comparative double-blind trial design. A total of sixty-two patients were admitted to the trial and were randomly allocated to one or other of the dosage regimes. Patients were assessed weekly for five weeks. More favourable results were achieved with patients taking the single dose nocturnally which was well tolerated in addition to being effective in relieving symptoms of depression. A number of possible advantages of this method of administration are discussed.


2015 ◽  
Vol 29 (8) ◽  
pp. 1304-1309 ◽  
Author(s):  
Yutaka Seino ◽  
Daisuke Yabe ◽  
Akane Takami ◽  
Elisabeth Niemoeller ◽  
Hiroki Takagi

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