scholarly journals Alpha2Delta Calcium Channel Subunit Constrains Steep Dependence of Release Probability on Calcium Channel Density through Coupling to Kv1.1 at Nerve Terminals

2013 ◽  
Vol 104 (2) ◽  
pp. 499a
Author(s):  
Michael B. Hoppa ◽  
Timothy A. Ryan
Keyword(s):  
Calcium Channel ◽  
Nerve Terminals ◽  
Channel Density ◽  
Release Probability

scholarly journals Primary and secondary motoneurons use different calcium channel types to control escape and swimming behaviors in zebrafish

2020 ◽  
Author(s):  
Hua Wen ◽  
Kazumi Eckenstein ◽  
Vivien Weihrauch ◽  
Christian Stigloher ◽  
Paul Brehm
Keyword(s):  
Calcium Channels ◽  
Calcium Channel ◽  
Muscle Cell ◽  
Transmitter Release ◽  
Escape Response ◽  
Quantal Content ◽  
Release Probability ◽  
High Release ◽  
Postsynaptic Cell ◽  
Rhythmic Contractions

AbstractThe escape response and rhythmic swimming in zebrafish are distinct behaviors mediated by two functionally distinct motoneuron (Mn) types. The primary (1°Mn) type depresses, has a large quantal content (Qc), and a high release probability (Pr). Conversely, the secondary (2°Mn) type facilitates and has low and variable Qc and Pr. This functional duality matches well the distinct associated behaviors, with the 1°Mn providing the strong, singular C-bend initiating escape and the 2°Mn confers weaker, rhythmic contractions. Contributing to these functional distinctions is our identification of P/Q type calcium channels mediating transmitter release in 1°Mns and N type channels in 2°Mns. Remarkably, despite these functional and behavioral distinctions, all ~15 individual synapses on each muscle cell are shared by a 1°Mn bouton and at least one 2°Mn bouton. This novel blueprint of synaptic sharing provides an efficient way of controlling two different behaviors at the level of a single postsynaptic cell.

Equal changes in L-type calcium channel density after 60 min of ischaemia in normal and ischaemically preconditioned porcine myocardium

1996 ◽  
Vol 157 (2) ◽  
pp. 147-155 ◽  
Author(s):  
M. STOKKE ◽  
K. A. KIRKEBØEN ◽  
P. A. NAESS ◽  
E. M. HAGELIN ◽  
A. ILEBEKK ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Channel Density

scholarly journals Peptidomimetic Targeting of Ca v β2 Overcomes Dysregulation of the L-Type Calcium Channel Density and Recovers Cardiac Function

Circulation ◽  
2016 ◽  
Vol 134 (7) ◽  
pp. 534-546 ◽  
Author(s):  
Francesca Rusconi ◽  
Paola Ceriotti ◽  
Michele Miragoli ◽  
Pierluigi Carullo ◽  
Nicolò Salvarani ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Calcium Channel ◽  
Channel Density
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