High-Throughput Screening of Nav1.7 Sodium Channel Blockers in an Automated Patch Clamp Assay

Channel Blockers ◽

Sodium Channel Blockers ◽

Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment

Journal of Pharmacological and Toxicological Methods ◽

10.1016/j.vascn.2021.107125 ◽

2021 ◽

Vol 112 ◽

pp. 107125 ◽

Cited By ~ 1

Author(s):

Maria Giustina Rotordam ◽

Alison Obergrussberger ◽

Nina Brinkwirth ◽

Kiyoshi Takasuna ◽

Nadine Becker ◽

...

Keyword(s):

Drug Discovery ◽

Best Practices ◽

Patch Clamp ◽

High Throughput ◽

Cardiac Conduction ◽

Peak Current ◽

Reliable Identification ◽

Conduction Abnormalities ◽

Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp-based high-throughput screening techniques

Acta Pharmacologica Sinica ◽

10.1038/aps.2015.142 ◽

2016 ◽

Vol 37 (1) ◽

pp. 105-110 ◽

Cited By ~ 5

Author(s):

Jin-feng Yue ◽

Guan-hua Qiao ◽

Ni Liu ◽

Fa-jun Nan ◽

Zhao-bing Gao

Keyword(s):

Patch Clamp ◽

High Throughput ◽

Screening Techniques ◽

High-Throughput Screening of NaV1.7 Modulators Using a Giga-Seal Automated Patch Clamp Instrument

Assay and Drug Development Technologies ◽

10.1089/adt.2016.700 ◽

2016 ◽

Vol 14 (2) ◽

pp. 93-108 ◽

Cited By ~ 18

Author(s):

Chris Chambers ◽

Ian Witton ◽

Cathryn Adams ◽

Luke Marrington ◽

Juha Kammonen

Keyword(s):

Patch Clamp ◽

High Throughput ◽

Automated Patch Clamp Meets High-Throughput Screening: 384 Cells Recorded in Parallel on a Planar Patch Clamp Module

Journal of Laboratory Automation ◽

10.1177/2211068215623209 ◽

2015 ◽

Vol 21 (6) ◽

pp. 779-793 ◽

Cited By ~ 19

Author(s):

A. Obergrussberger ◽

A. Bru ggemann ◽

T. A. Goetze ◽

M. Rapedius ◽

C. Haarmann ◽

...

Keyword(s):

Patch Clamp ◽

High Throughput ◽

Faculty Opinions recommendation of Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1092130.553236 ◽

2007 ◽

Author(s):

David Archer

Keyword(s):

Sodium Channel ◽

Channel Blockers ◽

Sodium channel blockers for cystic fibrosis

10.1002/14651858.cd005087 ◽

2005 ◽

Cited By ~ 1

Author(s):

E Burrows ◽

KW Southern ◽

P Noone

Keyword(s):

Cystic Fibrosis ◽

Sodium Channel ◽

Channel Blockers ◽

Reconsidering the role of selective sodium channel blockers in genetic generalized epilepsy

Acta Neurologica Scandinavica ◽

10.1111/ane.13509 ◽

2021 ◽

Author(s):

Emanuele Cerulli Irelli ◽

Alessandra Morano ◽

Martina Fanella ◽

Biagio Orlando ◽

Enrico M Salamone ◽

...

Keyword(s):

Sodium Channel ◽

Channel Blockers ◽

Sodium Channel Blockers ◽

Generalized Epilepsy

ChemInform Abstract: Substituted Biaryl Pyrazoles as Sodium Channel Blockers.

ChemInform ◽

10.1002/chin.201052122 ◽

2010 ◽

Vol 41 (52) ◽

pp. no-no

Author(s):

Sriram Tyagarajan ◽

et al. et al.

Keyword(s):

Sodium Channel ◽

Channel Blockers ◽

Diphenytoin, riluzole and lidocaine: Three sodium channel blockers, with different mechanisms of action, decrease hippocampal epileptiform activity

Neuropharmacology ◽

10.1016/j.neuropharm.2013.04.057 ◽

2013 ◽

Vol 73 ◽

pp. 48-55 ◽

Cited By ~ 10

Author(s):

Lihong Diao ◽

Jennifer L. Hellier ◽

Jessica Uskert-Newsom ◽

Philip A. Williams ◽

Kevin J. Staley ◽

...

Keyword(s):

Sodium Channel ◽

Epileptiform Activity ◽

Mechanisms Of Action ◽

Channel Blockers ◽

Synthesis And Biological Evaluation

Synthesis and biological evaluation of pyrrolidine derivatives as novel and potent sodium channel blockers for the treatment of ischemic stroke

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2013.05.009 ◽

2013 ◽

Vol 23 (14) ◽

pp. 4230-4234 ◽

Cited By ~ 4

Author(s):

Maki Seki ◽

Osamu Tsuruta ◽

Ryo Tatsumi ◽

Aki Soejima

Keyword(s):

Ischemic Stroke ◽

Sodium Channel ◽

Biological Evaluation ◽

Channel Blockers ◽

Sodium Channel Blockers ◽