Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment

2021 ◽  
Vol 112 ◽  
pp. 107125 ◽  
Author(s):  
Maria Giustina Rotordam ◽  
Alison Obergrussberger ◽  
Nina Brinkwirth ◽  
Kiyoshi Takasuna ◽  
Nadine Becker ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Best Practices ◽  
Patch Clamp ◽  
High Throughput ◽  
High Throughput Screening ◽  
Cardiac Conduction ◽  
Peak Current ◽  
Reliable Identification ◽  
Conduction Abnormalities ◽  
Automated Patch Clamp

scholarly journals Reliable Identification of hERG Liability in Drug Discovery by Automated Patch Clamp

2020 ◽  
Vol 118 (3) ◽  
pp. 116a-117a
Author(s):  
Michael George ◽  
Rodolfo Haedo ◽  
Nina Brinkwirth ◽  
Nadine Becker ◽  
Claudia S. Haarmann ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Patch Clamp ◽  
Reliable Identification ◽  
Automated Patch Clamp

Reliable identification of hERG liability in drug discovery by automated patch clamp

2020 ◽  
Vol 105 ◽  
pp. 106743
Author(s):  
Sonja Stoelzle-Feix ◽  
Nina Brinkwirth ◽  
Nadine Becker ◽  
Claudia Haarmann ◽  
Ronald Knox ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Patch Clamp ◽  
Reliable Identification ◽  
Automated Patch Clamp

High-Throughput Screening of NaV1.7 Modulators Using a Giga-Seal Automated Patch Clamp Instrument

2016 ◽  
Vol 14 (2) ◽  
pp. 93-108 ◽  
Author(s):  
Chris Chambers ◽  
Ian Witton ◽  
Cathryn Adams ◽  
Luke Marrington ◽  
Juha Kammonen
Keyword(s):  
Patch Clamp ◽  
High Throughput ◽  
High Throughput Screening ◽  
Automated Patch Clamp

An update on the advancing high-throughput screening techniques for patch clamp-based ion channel screens: implications for drug discovery

2018 ◽  
Vol 13 (3) ◽  
pp. 269-277 ◽  
Author(s):  
Alison Obergrussberger ◽  
Tom A. Goetze ◽  
Nina Brinkwirth ◽  
Nadine Becker ◽  
Søren Friis ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Patch Clamp ◽  
Ion Channel ◽  
High Throughput ◽  
High Throughput Screening ◽  
Screening Techniques

scholarly journals Automated Patch Clamp Meets High-Throughput Screening: 384 Cells Recorded in Parallel on a Planar Patch Clamp Module

2015 ◽  
Vol 21 (6) ◽  
pp. 779-793 ◽  
Author(s):  
A. Obergrussberger ◽  
A. Bru ggemann ◽  
T. A. Goetze ◽  
M. Rapedius ◽  
C. Haarmann ◽  
...  
Keyword(s):  
Patch Clamp ◽  
High Throughput ◽  
High Throughput Screening ◽  
Automated Patch Clamp

Upscaling and Automation of Electrophysiology: Toward High Throughput Screening in Ion Channel Drug Discovery

2003 ◽  
Vol 9 (1) ◽  
pp. 49-58
Author(s):  
Margit Asmild ◽  
Nicholas Oswald ◽  
Karen M. Krzywkowski ◽  
Søren Friis ◽  
Rasmus B. Jacobsen ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Ion Channel ◽  
High Throughput ◽  
High Throughput Screening
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