scholarly journals Differential Adhesion and Periodic Oscillations of Myosin-II Mechanically Proofread Filopodia Interactions during Embryonic Heart Formation

2021 ◽  
Vol 120 (3) ◽  
pp. 193a
Author(s):  
Timothy E. Saunders ◽  
Shaobo Zhang ◽  
Sham Tlili
2007 ◽  
Vol 130 (2) ◽  
pp. 133-144 ◽  
Author(s):  
Philipp Sasse ◽  
Jianbao Zhang ◽  
Lars Cleemann ◽  
Martin Morad ◽  
Juergen Hescheler ◽  
...  

Early (E9.5–E11.5) embryonic heart cells beat spontaneously, even though the adult pacemaking mechanisms are not yet fully established. Here we show that in isolated murine early embryonic cardiomyocytes periodic oscillations of cytosolic Ca2+ occur and that these induce contractions. The Ca2+ oscillations originate from the sarcoplasmic reticulum and are dependent on the IP3 and the ryanodine receptor. The Ca2+ oscillations activate the Na+-Ca2+ exchanger, giving rise to subthreshold depolarizations of the membrane potential and/or action potentials. Although early embryonic heart cells are voltage-independent Ca2+ oscillators, the generation of action potentials provides synchronization of the electrical and mechanical signals. Thus, Ca2+ oscillations pace early embryonic heart cells and the ensuing activation of the Na+-Ca2+ exchanger evokes small membrane depolarizations or action potentials.


2020 ◽  
Vol 30 (17) ◽  
pp. 3364-3377.e4 ◽  
Author(s):  
Shaobo Zhang ◽  
Xiang Teng ◽  
Yusuke Toyama ◽  
Timothy E. Saunders

2006 ◽  
Vol 33 (3) ◽  
pp. 199-205
Author(s):  
Li-Guo GONG ◽  
Guang-Rong QIU ◽  
Na XIN ◽  
Xiao-Yan XU ◽  
Kai-Lai SUN

2017 ◽  
Vol 145 ◽  
pp. S156
Author(s):  
Shaobo Zhang ◽  
Timothy Saunders

1979 ◽  
Vol 46 ◽  
pp. 77-88
Author(s):  
Edward L. Robinson

Three distinct kinds of rapid variations have been detected in the light curves of dwarf novae: rapid flickering, short period coherent oscillations, and quasi-periodic oscillations. The rapid flickering is seen in the light curves of most, if not all, dwarf novae, and is especially apparent during minimum light between eruptions. The flickering has a typical time scale of a few minutes or less and a typical amplitude of about .1 mag. The flickering is completely random and unpredictable; the power spectrum of flickering shows only a slow decrease from low to high frequencies. The observations of U Gem by Warner and Nather (1971) showed conclusively that most of the flickering is produced by variations in the luminosity of the bright spot near the outer edge of the accretion disk around the white dwarf in these close binary systems.


1981 ◽  
Vol 42 (C7) ◽  
pp. C7-51-C7-56
Author(s):  
K. Aoki ◽  
T. Kobayashi ◽  
K. Yamamoto

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