scholarly journals Secondary sources of negative symptoms in those meeting criteria for a clinical high-risk syndrome

2021 ◽  
Author(s):  
Tina Gupta ◽  
Gregory P. Strauss ◽  
Henry R. Cowan ◽  
Andrea Pelletier-Baldelli ◽  
Lauren M. Ellman ◽  
...  
Keyword(s):  
High Risk ◽  
Negative Symptoms ◽  
Clinical High Risk ◽  
Secondary Sources

scholarly journals Longitudinal outcome of attenuated positive symptoms, negative symptoms, functioning and remission in people at clinical high risk for psychosis: a meta-analysis

2021 ◽  
Vol 36 ◽  
pp. 100909
Author(s):  
Gonzalo Salazar de Pablo ◽  
Filippo Besana ◽  
Vincenzo Arienti ◽  
Ana Catalan ◽  
Julio Vaquerizo-Serrano ◽  
...  
Keyword(s):  
High Risk ◽  
Negative Symptoms ◽  
Meta Analysis ◽  
Positive Symptoms ◽  
Clinical High Risk ◽  
Longitudinal Outcome

scholarly journals Association of baseline inflammatory markers and the development of negative symptoms in individuals at clinical high risk for psychosis

2019 ◽  
Vol 76 ◽  
pp. 268-274 ◽  
Author(s):  
David R. Goldsmith ◽  
Ebrahim Haroon ◽  
Andrew H. Miller ◽  
Jean Addington ◽  
Carrie Bearden ◽  
...  
Keyword(s):  
High Risk ◽  
Inflammatory Markers ◽  
Negative Symptoms ◽  
Clinical High Risk

scholarly journals Negative symptoms in individuals at clinical high risk of psychosis

2012 ◽  
Vol 196 (2-3) ◽  
pp. 220-224 ◽  
Author(s):  
Danijela Piskulic ◽  
Jean Addington ◽  
Kristin S. Cadenhead ◽  
Tyrone D. Cannon ◽  
Barbara A. Cornblatt ◽  
...  
Keyword(s):  
High Risk ◽  
Negative Symptoms ◽  
Clinical High Risk

Delay discounting in youth at clinical high-risk for psychosis and adults with schizophrenia

2020 ◽  
pp. 1-8 ◽  
Author(s):  
Lisa A. Bartolomeo ◽  
Hannah C. Chapman ◽  
Ian M. Raugh ◽  
Gregory P. Strauss
Keyword(s):  
High Risk ◽  
Delay Discounting ◽  
Negative Symptoms ◽  
Chronic Phase ◽  
Reward Processing ◽  
Positive Symptoms ◽  
Clinical High Risk ◽  
Symptom Scale ◽  
Processing Mechanism ◽  
Value Representation

Abstract Background Schizophrenia (SZ) is typically preceded by a prodromal (i.e. pre-illness) period characterized by attenuated positive symptoms and declining functional outcome. Negative symptoms are prominent among individuals at clinical high-risk (CHR) for psychosis (i.e. those with prodromal syndromes) and highly predictive of conversion to illness. Mechanisms underlying negative symptoms in the CHR population are unclear. Two studies were conducted to evaluate whether abnormalities in a reward processing mechanism thought to be core to negative symptoms in SZ, value representation, also exist in CHR individuals and whether they are associated with negative symptoms transphasically. Methods Study 1 included 33 individuals in the chronic phase of illness who have been diagnosed with schizophrenia or schizoaffective disorder (SZ) and 40 healthy controls (CN). Study 2 included 37 CHR participants and 45 CN. In both studies, participants completed the delay discounting (DD) task as a measure of value representation and the Brief Negative Symptom Scale was rated to measure negative symptoms. Results Results indicated that patients with SZ had steeper discounting rates than CN, indicating impairments in value representation. However, CHR participants were unimpaired on the DD task. In both studies, steeper discounting was associated with greater severity of negative symptoms. Conclusions These findings suggest that deficits in value representation are associated with negative symptoms transphasically.

scholarly journals Anomalous self-experiences are strongly associated with negative symptoms in a clinical high-risk for psychosis sample

2019 ◽  
Vol 93 ◽  
pp. 65-72 ◽  
Author(s):  
Tor Gunnar Værnes ◽  
Jan Ivar Røssberg ◽  
Paul Møller
Keyword(s):  
High Risk ◽  
Negative Symptoms ◽  
Clinical High Risk

scholarly journals SU127. Negative Symptoms in Youth at Clinical High Risk of Psychosis

2017 ◽  
Vol 43 (suppl_1) ◽  
pp. S207-S208 ◽  
Author(s):  
Daniel Devoe ◽  
Kristen Cadenhead ◽  
Tyrone Cannon ◽  
Barbara Cornblatt ◽  
Tom McGlashan ◽  
...  
Keyword(s):  
High Risk ◽  
Negative Symptoms ◽  
Clinical High Risk

Attenuated negative symptoms in individuals at clinical high risk for psychosis

2013 ◽  
Vol 54 (8) ◽  
pp. e19 ◽  
Author(s):  
D.L. Demmin ◽  
R.E. Carrión ◽  
A. Auther ◽  
D. McLaughlin ◽  
B.A. Cornblatt
Keyword(s):  
High Risk ◽  
Negative Symptoms ◽  
Clinical High Risk

S239. Sub Domains of Negative Symptoms in Individuals at Clinical High Risk for Psychosis

2018 ◽  
Vol 83 (9) ◽  
pp. S441
Author(s):  
Matilda Azis ◽  
Gregory P. Strauss ◽  
Elaine Walker ◽  
Vijay Mittal
Keyword(s):  
High Risk ◽  
Negative Symptoms ◽  
Clinical High Risk

Timing dysfunction and cerebellar resting state functional connectivity abnormalities in youth at clinical high-risk for psychosis

2020 ◽  
pp. 1-10 ◽  
Author(s):  
K. Juston Osborne ◽  
Katherine S. F. Damme ◽  
Tina Gupta ◽  
Derek J. Dean ◽  
Jessica A. Bernard ◽  
...  
Keyword(s):  
High Risk ◽  
Resting State ◽  
Negative Symptoms ◽  
Brain Regions ◽  
Internal Clock ◽  
Clinical High Risk ◽  
Resting State Functional Connectivity ◽  
Schizophrenia Spectrum ◽  
Temporal Bisection Task ◽  
Resting State Connectivity

Abstract Background Consistent with pathophysiological models of psychosis, temporal disturbances in schizophrenia spectrum populations may reflect abnormal cortical (e.g. prefrontal cortex) and subcortical (e.g. striatum) cerebellar connectivity. However, few studies have examined associations between cerebellar connectivity and timing dysfunction in psychosis populations, and none have been conducted in youth at clinical high-risk (CHR) for psychosis. Thus, it is currently unknown if impairments in temporal processes are present in CHR youth or how they may be associated with cerebellar connectivity and worsening of symptoms. Methods A total of 108 (56 CHR/52 controls) youth were administered an auditory temporal bisection task along with a resting state imaging scan to examine cerebellar resting state connectivity. Positive and negative symptoms at baseline and 12 months later were also quantified. Results Controlling for alcohol and cannabis use, CHR youth exhibited poorer temporal accuracy compared to controls, and temporal accuracy deficits were associated with abnormal connectivity between the bilateral anterior cerebellum and a right caudate/nucleus accumbens striatal cluster. Poor temporal accuracy accounted for 11% of the variance in worsening of negative symptoms over 12 months. Conclusions Behavioral findings suggest CHR youth perceive durations of auditory tones as shortened compared to objective time, which may indicate a slower internal clock. Poorer temporal accuracy in CHR youth was associated with abnormalities in brain regions involved in an important cerebellar network implicated in prominent pathophysiological models of psychosis. Lastly, temporal accuracy was associated with worsening of negative symptoms across 12 months, suggesting temporal dysfunction may be sensitive to illness progression.

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