symptom scale
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2022 ◽  
Vol 8 (4) ◽  
pp. 291-297
Author(s):  
M.S. Madhu ◽  
S.M. Ahmed ◽  
Raghavendra. K.V.

There are no approved drugs to treat COVID-19, and the vaccine is likely to be ready by early 2021. Many clinical studies are ongoing around the globe to find a cure or prevention of the disease. The objective of the proposed study is to determine the efficacy and safety profile of Mulmina Mango as an adjunct to standard of care treatment on COVID-19 positive subjects undergoing treatment for COVID-19 in Hospital Quarantine. Settings and Design: The enrolled subjects were randomized into either of the two treatment arms in the ratio of 1:1. The freshly diagnosed (24-48 hrs.) COVID-19 positive Male or Female is aged 20 to 65 years (both inclusive) hospitalized patients were approached and checked for their eligibility. They were recruited after signing the written informed consent form. The number of patients included in the study is 48. In efficacy, both the treatment arms and the reduction in clinical symptom scale value and ordinal scale value are seen on day 7. On the ordinal scale, 41.7% of subjects in Treatment arm A showed a reduction of 2 points on the day, and 16.7% of subjects show 2 points reduction in Treatment arm B. In Safety results, there was no clinically significant finding in safety parameters in Treatment arm B. Mulmina Mango showed encouraging results concerning RTPCR, CRP, Dopamine, IgG, CD4, and CD8 parameters. The properties of Mulmina Mango are highlighted below, along with the parameters for each property. Mulmina Mango, COVID-19, Treatment Arm A, Treatment Arm B, MoHFW (Ministry of Health and Family Welfare)


Author(s):  
Grant L. Iverson ◽  
Paul D. Berkner ◽  
Ross Zafonte ◽  
Bruce Maxwell ◽  
Douglas P. Terry

AbstractThis study examined the association between past concussions and current preseason symptom reporting and cognitive performance in 9,257 youth ages 11–13. Participants completed neurocognitive testing prior to participating in a school sports between 2009 and 2019. We stratified the sample by gender and number of prior concussions and assessed group differences on the Post-Concussion Symptom Scale total score and the ImPACT cognitive composite scores. Those with≥2 prior concussions reported more symptoms than those with 0 concussions (d=0.43–0.46). Multiple regressions examining the contribution of concussion history and developmental/health history to symptom reporting showed the most significant predictors of symptoms scores were (in descending order): treatment for a psychiatric condition, treatment for headaches, history of learning disability (in boys only), history of attention-deficit/hyperactivity disorder, and age. Concussion history was the weakest statistically significant predictor in boys and not significant in girls. Cognitively, boys with 1 prior concussion had worse speed those with 0 concussions (d=0.11), and girls with≥2 prior concussions had worse verbal/visual memory than girls with 0 concussions (ds=0.38–0.39). In summary, youth with≥2 prior concussions reported more symptoms than those with no concussions. Boys with multiple concussions performed similarly on cognitive testing, while girls had worse memory scores.


2021 ◽  
Vol 40 (2) ◽  
pp. 131-147
Author(s):  
Geovanna Santana De Souza Turri ◽  
Renata Elly Barbosa Fonte ◽  
Luiz Guilherme Lima-Silva ◽  
Andre Faro

This research compared evocations regarding the term “coronavirus” during two different periodsin the Covid-19 pandemic in Brazil in 2020 — March (beginning of the pandemic in the country)and June (Brazil as the epicenter of the pandemic) —, considering the presence or absence ofanxiety symptoms in participants. The methodology adopted the free evocation technique and theGeneralized Anxiety Disorder (GAD-2) symptom scale. The sample was composed of 5,961 womenand 1,153 men. Participant selection was relegated to convenience sampling by means of an onlinequestionnaire. Results showed that the coronavirus had diff erential impacts among the groups thatwere assessed and according to the time of data collection. In general, in March, people with anxietysymptoms had a more catastrophic view of the future, while people without those symptoms had aless unfavorable repertoire to adjust to the situation. In June, both groups reported a negative viewof the scenario, indicating a decrease or exhaustion in their capacity for psychological adjustment.This suggests the possibility of an increase of some conditions that result in adaptive impairment,exhaustion, and mental illness. Finally, it is important to understand people’s beliefs about the coronavirusat diff erent times of the pandemic because it is a favorable period for the emergence and/orintensification of mental disorders.


Neurology ◽  
2021 ◽  
Vol 98 (1 Supplement 1) ◽  
pp. S12.1-S12
Author(s):  
Jacob I. McPherson ◽  
Patrick Sparks ◽  
Mohammad Nadir Haider ◽  
Barry Stewart Willer ◽  
John J. Leddy

ObjectiveTo determine if concussed adolescents with positive cervical findings on examination provided with early cervical treatment demonstrate recovery time and incidence of persistent post-concussive symptoms (PPCS, recovery = 30 days) comparable to those without cervical findings.BackgroundCervical impairments resulting from concussive injury are historically associated with longer recovery times. Concomitant cervical injuries may result in symptoms that overlap with concussion, including headache, dizziness, tinnitus, sleep disturbances, and blurred vision. Current recommendations include assessment of the cervical spine; however, there is limited evidence for the effect of immediate cervical intervention on recovery.Design/MethodsRetrospective case-controlled study. Patients included adolescents with acute concussion presenting with (n = 132, 14.99 ± 1.9 years, 58% male, 5.70 ± 3.3 days since injury) and without (n = 138, 14.85 ± 1.8 years, 65% male, 6.13 ± 3.4 days since injury) cervical findings on physical exam. Patients were assessed with the Buffalo Concussion Physical Examination (BCPE), Neck Disability Index (NDI) and Post-Concussion Symptom Scale (PCSS) instruments. Groups were separated based on positive or negative cervical findings on the BCPE. Cervical impairments were addressed by physicians specializing in concussion management using a clinical algorithm. Mild impairments were managed conservatively (over-the-counter analgesics, warm/cold compresses, and/or neck stretching exercises). Patients with moderate or greater impairments were assessed by a physical therapist at the initial clinic encounter and given specific cervical interventions.ResultsPhysician-observed cervical findings had moderate agreement with self-reported function on the NDI (? = 0.414, p < 0.001). Patients with cervical findings reported greater symptom severity on the PCSS (37.9 ± 22.1 vs 30.8 ± 20.2, p = 0.011); however, there was no significant difference in recovery time (34.44 ± 33.2 vs 34.81 ± 39.0 days, p = 0.933) or incidence of persistent symptoms (39% vs 35%, p = 0.511).ConclusionsIn this group of adolescents, cervical impairment managed early after concussion was not associated with prolonged recovery. Early management of cervical impairments may reduce the development of PPCS. Prospective evaluation is warranted.


2021 ◽  
Vol 13 ◽  
Author(s):  
Bei Cao ◽  
Yan Liang ◽  
Ling-Yu Zhang ◽  
Yan-Bing Hou ◽  
Ru-Wei Ou ◽  
...  

Background: Few studies have focused on the cold hand sign (CHS), a red flag symptom, in multiple system atrophy (MSA).Objective: This study aimed to investigate the frequency and correlative factors of CHS in patients with MSA and the impact of its early occurrence on the survival of these patients.Methods: A total of 483 patients with MSA were enrolled in this study, and the motor and non-motor symptoms between patients with MSA with and without CHS were compared. Moreover, patients with disease duration ≤ 3 years at baseline were followed, and the association between CHS and survival of patients with MSA was examined.Results: The frequencies of CHS in patients with MSA were 20, 15.4, and 25.3% in MSA, MSA-parkinsonian subtype (MSA-P), and MSA-cerebellar subtype (MSA-C), respectively. Higher Unified Multiple System Atrophy Rating Scale (UMSARS) scores and higher Non-Motor Symptom Scale (NMSS) scores at baseline were associated with CHS in MSA. CHS was associated with shorter survival after adjusting for baseline diagnosis subtype, age at onset, sex, orthostatic hypotension, disease duration, autonomic onset, UMSARS total score, and NMSS score (p = 0.001; HR = 3.701; 95% CI = 1.765–7.760).Conclusion: CHS is not rare in patients with MSA. Greater disease severity and more severe non-motor symptoms were associated with CHS in patients with MSA. Patients with early occurrence of CHS had a poor prognosis.


2021 ◽  
Vol 12 ◽  
Author(s):  
Giulia M. Giordano ◽  
Francesco Brando ◽  
Andrea Perrottelli ◽  
Giorgio Di Lorenzo ◽  
Alberto Siracusano ◽  
...  

Background: Negative symptoms represent a heterogeneous dimension with a strong impact on functioning of subjects with schizophrenia (SCZ). Five constructs are included in this dimension: anhedonia, asociality, avolition, blunted affect, and alogia. Factor analyses revealed that these symptoms cluster in two domains: experiential domain (avolition, asociality, and anhedonia) and the expressive deficit (alogia and blunted affect), that might be linked to different neurobiological alterations. Few studies investigated associations between N100, an electrophysiological index of early sensory processing, and negative symptoms, reporting controversial results. However, none of these studies investigated electrophysiological correlates of the two negative symptom domains.Objectives: The aim of our study was to evaluate, within the multicenter study of the Italian Network for Research on Psychoses, the relationships between N100 and negative symptom domains in SCZ.Methods: Auditory N100 was analyzed in 114 chronic stabilized SCZ and 63 healthy controls (HCs). Negative symptoms were assessed with the Brief Negative Symptom Scale (BNSS). Repeated measures ANOVA and correlation analyses were performed to evaluate differences between SCZ and HCs and association of N100 features with negative symptoms.Results: Our findings demonstrated a significant N100 amplitude reduction in SCZ compared with HCs. In SCZ, N100 amplitude for standard stimuli was associated with negative symptoms, in particular with the expressive deficit domain. Within the expressive deficit, blunted affect and alogia had the same pattern of correlation with N100.Conclusion: Our findings revealed an association between expressive deficit and N100, suggesting that these negative symptoms might be related to deficits in early auditory processing in SCZ.


2021 ◽  
Vol 9 ◽  
Author(s):  
Shuang Dai ◽  
Xiaoqin Liu ◽  
Xi Chen ◽  
Jun Bie ◽  
Chi Du ◽  
...  

Objective: To explore the current situation of the out-of-hospital management of patients with cancer and evaluate the feasibility of Internet medical intervention outside the hospital in China.Methods: The questionnaire was designed based on the investigators' clinical experience, literature data, and the Anderson Symptom Scale, and adopted a cross sectional survey method.Results: Totally 1,171 qualified questionnaires were analyzed. The results showed that 92.7% of patients with cancer experienced varying degrees of out-of-hospital symptoms after treatment, and a third of them needed clinical intervention. Abnormal blood test results outside the hospital were basically consistent with the events that occurred during the hospitalization. One third of patients with cancer could not identify abnormal results. The primary approaches to solve these abnormalities were to seek guidance from the physician in charge or from nearby hospitals, but only 6.75% patients sought help online. More than half of the life or work of patients with cancer are still greatly affected under the current management model. 92% of respondents required medical help outside the hospital, and 65% ones were willing to pay for the out-of-hospital management.Conclusions: Out-of-hospital management model needs to be improved. Most users are willing to accept Internet cancer management with fees. The survey has a positive effect on guiding future Internet cancer management practices in China to a certain extent.


Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4449
Author(s):  
Gemma Caterina Maria Rossi ◽  
Luigia Scudeller ◽  
Federica Bettio ◽  
Giovanni Milano

The aims of the study were to investigate the ability and effectiveness of an oral intake of a fixed combination of zinc, L-carnitine, elderberry extract, black currant and Eleutherococcus extract in controlling the symptoms of eyestrain in videoterminal (VDT) users and to record its effects on contrast sensitivity. A single-center, phase II, observational, case-control, 1-month study in VDT workers without dry eye disease was carried out. Demographics and number of actual hours at VDT/day were taken into account. All subjects underwent a complete ophthalmic examination, including assessment of contrast sensitivity, and completed the computer vision symptom scale questionnaire at baseline and one month later. A total of 30 Caucasian subjects adhered to the required inclusion criteria and completed the study; 15 subjects were treated (T) and 15 were controls (C). All clinical data at baseline were similar in both groups (p > 0.05): after one month, all subjects had stable visual acuity, refractive defect and intraocular pressure (IOP); screen exposure time was unchanged. Regarding symptoms, at randomization, the groups had a similar score: 33.1 ± 3.3 in T and 32.8 ± 5.6 in C. One month later, the computer vision symptom scale (CVSS) questionnaire score decreased by −14.1 ± 3, 1 (p = 0.000) and −2.3 ± 1.8 (p = 0.568), respectively. Regarding contrast sensitivity, in group C the values of spatial frequencies remained unchanged, while they improved in almost all the cycles per degree stimuli in the treated group. Oral intake of a fixed combination of zinc, L-carnitine, elderberry extract, black currant and eleutherococcus extract can significantly improve contrast sensitivity and symptoms in VDT workers with no signs of dry eye disease.


Author(s):  
Anna Chakraborty ◽  

Background:The recent COVID-19 pandemic caused by the new strain of coronavirus (SARS-CoV-2) was first diagnosed in Wuhan, China in late December of 2019. Coronavirus disease (COVID-19) has a large negative psychological effect and mental health issues worldwide due to its high morbidity and mortality rates. The unexpectedly rapid spread of COVID -19 endowed HCWs with increased work burden, lack of personal protective equipment, high risk of exposure and contracting the diseases, as well as increased mortality amongst HCWs. Materials and Methods: This cross-sectional study was carry out to assess the Mental Health status of the professionals working with Covid-19 at Hospital in Dhaka. Primary data were collected through field survey including the observation and interview method. This survey, were covered doctors, nurses and Medical technicians in all clinical departments of Kuwait Bangladesh Friendship Government Hospital, Uttara, Dhaka between 1st May to July 30th, 2021. Mental health variables were assessed via Somatic Symptom scale-8 (SSS-8).


Author(s):  
Stephanie Rose Harrison ◽  
Marco Garrido-Cumbrera ◽  
Victoria Navarro-Compán ◽  
José Correa-Fernández ◽  
Dale Webb ◽  
...  

Abstract Objectives To compare the impact of the first wave of the COVID-19 pandemic and lockdown measures on patients with rheumatic and musculoskeletal diseases (RMDs) in the UK and other European countries (OEC). Methods REUMAVID was an online cross-sectional survey of seven European countries. Data collected included: demographics, lifestyle, employment, access to healthcare services, disease-specific characteristics, WHO-5 Well-Being Index, Hospital Anxiety and Depression Scale (HADS), Visual Analogue Scale (VAS) disease activity, and the Perceived Acceptable Symptom Scale. Results 1,800 responses were received between April and July 2020 [UK, n = 558(31.0%); OEC, n = 1,242(69.0%)]. UK patients were more likely to be older (UK 58.5years±13.4; OEC 50.0years±12.2), university educated [UK n = 302(54.1%); OEC n = 572(46.1%), quit smoking [UK n = 92(59.4%); OEC n = 65(16.2%)] and continue exercise [UK, n = 216(49.2%); OEC, n = 228(33.1%)], although conversely alcohol consumption increased [UK n = 99(36.3%); OEC n = 98(12.1%)]. UK patients felt informed about COVID-19 (UK 72.7%, OEC 57.4%) and kept their planned rheumatology [UK n = 87(51.2%); OEC n = 213(38.6%)] and/or GP appointments [UK n = 87(76.3%); OEC n = 310(53.9%)]. Almost half of patients with RMDs reported a decline in health and wellbeing, though this was less common in UK patients [UK n = 214(38.4%), OEC n = 618(50.2%)] who reported better perceived acceptable symptom scale, VAS pain and HADS scores, but worse WHO-5 scores. Conclusions UK RMD patients performed better in the physical and mental health domains tested possibly due to a less restrictive lockdown and improved healthcare access. These findings have implications for healthcare services globally in planning patient care after the COVID-19 pandemic.


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