Nociceptive, emotional, electrophysiological, and histological characterization of the chronic constriction injury model in female Wistar Han rats

2021 ◽  
Vol 167 ◽  
pp. 56-70
Author(s):  
Diana Fonseca-Rodrigues ◽  
Inês Laranjeira ◽  
João Barbosa ◽  
Nuno Jorge Lamas ◽  
Diana Amorim ◽  
...  
Keyword(s):  
Chronic Constriction Injury ◽  
Injury Model ◽  
Chronic Constriction Injury Model

Characterization of the sensory, affective, cognitive, biochemical, and neuronal alterations in a modified chronic constriction injury model of neuropathic pain in mice

2019 ◽  
Vol 98 (2) ◽  
pp. 338-352 ◽  
Author(s):  
Priscila Medeiros ◽  
Renato Leonardo Freitas ◽  
Serena Boccella ◽  
Monica Iannotta ◽  
Carmela Belardo ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Chronic Constriction Injury ◽  
Injury Model ◽  
Chronic Constriction Injury Model

Xanthine Derivative KMUP-1 Reduces Inflammation and Hyperalgesia in a Bilateral Chronic Constriction Injury Model by Suppressing MAPK and NFκB Activation

2014 ◽  
Vol 11 (5) ◽  
pp. 1621-1631 ◽  
Author(s):  
Zen-Kong Dai ◽  
Ting-Chun Lin ◽  
Jau-Cheng Liou ◽  
Kuang-I Cheng ◽  
Jun-Yih Chen ◽  
...  
Keyword(s):  
Chronic Constriction Injury ◽  
Xanthine Derivative ◽  
Injury Model ◽  
Chronic Constriction Injury Model

scholarly journals Tongluo Zhitong Prescription Alleviates Allodynia, Hyperalgesia, and Dyskinesia in the Chronic Constriction Injury Model of Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Zhiyong Wang ◽  
Jianwei Wang ◽  
Lihua Qin ◽  
Weiguang Zhang
Keyword(s):  
Neuropathic Pain ◽  
Mechanical Allodynia ◽  
Chronic Constriction Injury ◽  
Catgut Suture ◽  
Cold Allodynia ◽  
Injury Model ◽  
Neuropathic Pain Model ◽  
Gait Function ◽  
Chronic Constriction Injury Model ◽  
Heat Hyperalgesia

Neuropathic pain is common in clinical practice. Exploration of new drug therapeutics has always been carried out for more satisfactory effects and fewer side-effects. In the present study, we aimed to investigate effects of Tongluo Zhitong Prescription (TZP), a compounded Chinese medicine description, on neuropathic pain model of rats with chronic constriction injury (CCI). The CCI model was established by loosely ligating sciatic nerve with catgut suture, proximal to its trifurcation. The static and dynamic allodynia, heat hyperalgesia, mechanical allodynia, cold allodynia, and gait were assessed. Our results showed that TZP alleviated CCI-induced static and dynamic allodynia, suppressed heat hyperalgesia and cold and mechanical allodynia, and improved gait function. These results suggest that TZP could alleviate neuropathic pain. Further experiments are needed to explore its mechanisms.

scholarly journals Valproate reduces neuroinflammation and neuronal death in a rat chronic constriction injury model

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Jun-Yih Chen ◽  
Li-Wen Chu ◽  
Kuang-I Cheng ◽  
Su-Ling Hsieh ◽  
Yung-Shun Juan ◽  
...  
Keyword(s):  
Neuronal Death ◽  
Chronic Constriction Injury ◽  
Injury Model ◽  
Chronic Constriction Injury Model
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