scholarly journals Tongluo Zhitong Prescription Alleviates Allodynia, Hyperalgesia, and Dyskinesia in the Chronic Constriction Injury Model of Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Zhiyong Wang ◽  
Jianwei Wang ◽  
Lihua Qin ◽  
Weiguang Zhang
Keyword(s):  
Neuropathic Pain ◽  
Mechanical Allodynia ◽  
Chronic Constriction Injury ◽  
Catgut Suture ◽  
Cold Allodynia ◽  
Injury Model ◽  
Neuropathic Pain Model ◽  
Gait Function ◽  
Chronic Constriction Injury Model ◽  
Heat Hyperalgesia

Neuropathic pain is common in clinical practice. Exploration of new drug therapeutics has always been carried out for more satisfactory effects and fewer side-effects. In the present study, we aimed to investigate effects of Tongluo Zhitong Prescription (TZP), a compounded Chinese medicine description, on neuropathic pain model of rats with chronic constriction injury (CCI). The CCI model was established by loosely ligating sciatic nerve with catgut suture, proximal to its trifurcation. The static and dynamic allodynia, heat hyperalgesia, mechanical allodynia, cold allodynia, and gait were assessed. Our results showed that TZP alleviated CCI-induced static and dynamic allodynia, suppressed heat hyperalgesia and cold and mechanical allodynia, and improved gait function. These results suggest that TZP could alleviate neuropathic pain. Further experiments are needed to explore its mechanisms.

scholarly journals PENGUKURAN TINGKAH LAKU PADA MODEL NYERI NEUROPATIK PERIFER: TIKUS DENGAN CCI (CHRONIC CONSTRICTION INJURY)

2018 ◽  
Vol 35 (3) ◽  
Author(s):  
Hanik Badriyah Hidayati ◽  
Paulus Sugianto ◽  
Junaidi Khotib ◽  
Chrismawan Ardianto ◽  
Kuntoro Kuntoro ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Pain Threshold ◽  
Chronic Constriction Injury ◽  
Peripheral Neuropathic Pain ◽  
Pain Model ◽  
Threshold Test ◽  
Injury Model ◽  
Withdrawal Behavior ◽  
Neuropathic Pain Model ◽  
Chronic Constriction Injury Model

BEHAVIORAL ASSESMENT OF THE PERIPHERAL NEUROPATHIC PAIN MODEL: RAT WITH CCI (CHRONIC CONSTRICTION INJURY)ABSTRACTNeuropathic pain occurs in 20% of patients with chronic pain. This mainly due to the lack of effective treatment and the presence of drug’s side effects. Animal models have been broadly utilized in validating the therapeutic target and the development of analgesic drugs. Chronic constriction injury (CCI) is a model of peripheral neuropathic pain characterized by allodynia and hyperalgesia. Chronic constriction injury model is produced by loose ligation of the sciatic nerve resulting in nerve damage, thus sensitizes and lowers pain threshold. The pain threshold test is performed by providing a pressure and thermal sensory stimulus that results in observable withdrawal behavior. This article discusses several methods in assessing pain-related behavior on the CCI neuropathic pain model.Keywords: Behavioral, chronic constriction injury, mechanical, neuropathic painABSTRAKNyeri neuropatik terjadi pada seperlima pasien dengan nyeri kronik. Hal ini disebabkan karena terapi nyeri neuropatik masih kurang efektif dan adanya efek samping obat. Model hewan terbukti bermanfaat untuk validasi target dan perkembangan obat analgesik. Chronic constriction injury (CCI) merupakan model nyeri neuropatik perifer dengan karakteristik alodinia dan hiperalgesia. Model CCI dibuat dengan memberikan ligasi longgar pada saraf skiatik yang menyebabkan kerusakan saraf, sehingga terjadi sensitisasi dan ambang nyeri menurun. Tes ambang nyeri dilakukan dengan memberikan stimulus sensorik berupa tekanan dan panas yang akan menghasilkan tingkah laku withdrawal yang bisa diobservasi. Artikel ini membahas penilaian tingkah laku nyeri pada model nyeri neuropatik CCI.Kata kunci: Chronic constriction injury, mekanik, nyeri neuropatik, tingkah laku

The chronic constriction injury model of neuropathic pain

2018 ◽  
Author(s):  
Matthew Brown
Keyword(s):  
Neuropathic Pain ◽  
Chronic Constriction Injury ◽  
Subsequent Development ◽  
Human Condition ◽  
Sensory Testing ◽  
Cold Allodynia ◽  
Clinical Observations ◽  
Injury Model ◽  
Pain Models ◽  
Chronic Constriction Injury Model

The landmark paper discussed in this chapter is ‘A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man’, published by Bennett and Xie in 1988. This paper, in which the unilateral sciatic nerve chronic constriction injury (CCI) model was first presented, is one of the earliest and most comprehensive descriptions of a specific animal paradigm that was designed to model human neuropathic pain. The authors realized that human neuropathic pain rarely involves nerve transection but instead involves evoked changes in damaged and preserved nerve fibres. Furthermore, they systematically applied a barrage of sensory testing that demonstrated quantifiable hyperalgesia and cold allodynia reflecting some of the clinical observations of human neuropathic pain phenotype. CCI provided a high-quality template for the development of neuropathic pain models that impelled the subsequent development of other animal models striving to replicate the human condition faithfully and accurately.

scholarly journals Comparative efficacy of pregabalin and baclofen in the rodent chronic constriction injury model of neuropathic pain

2018 ◽  
Vol 8 (1) ◽  
pp. 133
Author(s):  
Saurabh Kohli ◽  
Taruna Sharma ◽  
Juhi Kalra ◽  
Dilip C. Dhasmana
Keyword(s):  
Neuropathic Pain ◽  
Sciatic Nerve ◽  
Chronic Constriction Injury ◽  
Thermal Hyperalgesia ◽  
Mechanical Hyperalgesia ◽  
Comparative Efficacy ◽  
First Line ◽  
Injury Model ◽  
Different Types ◽  
Chronic Constriction Injury Model

Background: Neuropathic pain is associated with prolonged disability and is usually not responsive to conventional analgesics like NSAIDs and opioids. Even the recommended first-line drugs are effective in less than 50% patients. Thus, drugs with different mechanisms of action are needed. Baclofen, a GABA-B agonist has shown benefit in different types of neuropathic pains and is compared against pregabalin.Methods: The sciatic nerve was ligated in 2 groups of 6 rats each as per the chronic constriction injury model of neuropathic pain on day 0. After 14 days the effect of single doses of pregabalin (30mg/kg) and baclofen (5mg/kg) intraperitoneally were assessed over a 2 hours period. Thermal and mechanical hyperalgesia were assessed as measures of neuropathic pain by the hotplate and pin-prick method respectively.Results: Significant thermal and mechanical hyperalgesia was produced 14 days after sciatic nerve ligation in both the groups (p <0.05). Both pregabalin (p <0.001) and baclofen (p <0.01) were effective in decreasing thermal hyperalgesia throughout the two hours study period, but pregabalin was more effective as compared to baclofen (p <0.05) at 30, 60 and 120minutes. Both the drugs produced a significant decrease in mechanical hyperalgesia (p <0.01) throughout the study period. Again, pregabalin was the more effective drug (p <0.05) at all time points.Conclusions: Significant thermal and mechanical hyperalgesia was seen 14 days after sciatic nerve ligation. Both pregabalin and baclofen were effective in reversing the hyperalgesia, but pregabalin was the more effective of the two drugs at all time points.

Characterization of the sensory, affective, cognitive, biochemical, and neuronal alterations in a modified chronic constriction injury model of neuropathic pain in mice

2019 ◽  
Vol 98 (2) ◽  
pp. 338-352 ◽  
Author(s):  
Priscila Medeiros ◽  
Renato Leonardo Freitas ◽  
Serena Boccella ◽  
Monica Iannotta ◽  
Carmela Belardo ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Chronic Constriction Injury ◽  
Injury Model ◽  
Chronic Constriction Injury Model

Localisation and modulation of prostanoid receptors EP1 and EP4 in the rat chronic constriction injury model of neuropathic pain

2007 ◽  
Vol 11 (6) ◽  
pp. 605-613 ◽  
Author(s):  
Peter L. Woodhams ◽  
Rachel E. MacDonald ◽  
Sue D. Collins ◽  
Iain P. Chessell ◽  
Nicola C. Day
Keyword(s):  
Neuropathic Pain ◽  
Chronic Constriction Injury ◽  
Prostanoid Receptors ◽  
Injury Model ◽  
Chronic Constriction Injury Model
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