Comparison of effect of a single-session of high- or low-frequency rTMS on cortical excitability in people with Parkinson’s disease – A randomised placebo controlled trial

2019 ◽  
Vol 12 (2) ◽  
pp. 446
Author(s):  
C. Chung ◽  
M. Mak
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cortical Excitability ◽  
Controlled Trial ◽  
Low Frequency ◽  
Single Session ◽  
Low Frequency Rtms

scholarly journals Training Effects Outweigh Effects of Single-Session Conventional rTMS and Theta Burst Stimulation in PD Patients

2008 ◽  
Vol 23 (4) ◽  
pp. 373-381 ◽  
Author(s):  
Holger Rothkegel ◽  
Martin Sommer ◽  
Thomas Rammsayer ◽  
Claudia Trenkwalder ◽  
Walter Paulus
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Primary Motor Cortex ◽  
Cortical Excitability ◽  
Single Session ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Training Effects ◽  
Pointing Movement ◽  
Theta Burst

Background. Focal single-session repetitive transcranial magnetic stimulation (rTMS) of the primary motor cortex has been claimed to be capable of improving motor function in Parkinson's disease. Objective. The authors sought to determine which type of rTMS protocol holds the highest potential for future therapeutic application. Methods. Twenty-two patients with Parkinson's disease received 5 different rTMS protocols on 5 consecutive days in a pseudorandomized and counterbalanced order either in the defined OFF condition or with their usual medication. The protocols tested in the present study included 2 conventional rTMS protocols (0.5 and 10 Hz) as well as the recently introduced theta burst stimulation (cTBS, iTBS) and a sham condition. Cortical excitability, motor performance (pointing movement, pronation-supination, Purdue Pegboard Test, walking), and mood were assessed before and after each session. Results . The authors observed motor training from days 1 to 4, particularly in the group on dopaminergic medication. None of the rTMS paradigms excelled placebo stimulation. The only exception was the Purdue Pegboard Test, in which all active stimulation paradigms yielded slightly stronger effects than sham stimulation. Conclusions. Within a single session, no clinically relevant difference in the rTMS protocols could be detected. Training effects outweigh and may have masked rTMS effects, particularly in the group on dopaminergic mediation.

Low frequency rTMS of the SMA transiently ameliorates peak-dose LID in Parkinson’s disease

2006 ◽  
Vol 117 (9) ◽  
pp. 1917-1921 ◽  
Author(s):  
Livia Brusa ◽  
Viviana Versace ◽  
Giacomo Koch ◽  
Cesare Iani ◽  
Paolo Stanzione ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Low Frequency ◽  
Peak Dose ◽  
Low Frequency Rtms

scholarly journals The Neuroprotective Mechanism of Low-Frequency rTMS on Nigral Dopaminergic Neurons of Parkinson’s Disease Model Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Qiaoyun Dong ◽  
Yanyong Wang ◽  
Ping Gu ◽  
Rusheng Shao ◽  
Li Zhao ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Dopaminergic Neuron ◽  
Neuroprotective Effect ◽  
Low Frequency ◽  
Brain Derived Neurotrophic Factor ◽  
Low Frequency Rtms

Background. Parkinson’s disease is a neurodegenerative disease in elder people, pathophysiologic basis of which is the severe deficiency of dopamine in the striatum. The purpose of the present study was to evaluate the neuroprotective effect of low-frequency rTMS on Parkinson’s disease in model mice.Methods. The effects of low-frequency rTMS on the motor function, cortex excitability, neurochemistry, and neurohistopathology of MPTP-induced Parkinson’s disease mice were investigated through behavioral detection, electrophysiologic technique, high performance liquid chromatography-electrochemical detection, immunohistochemical staining, and western blot.Results. Low-frequency rTMS could improve the motor coordination impairment of Parkinson’s disease mice: the resting motor threshold significantly decreased in the Parkinson’s disease mice; the degeneration of nigral dopaminergic neuron and the expression of tyrosine hydroxylase were significantly improved by low-frequency rTMS; moreover, the expressions of brain derived neurotrophic factor and glial cell line derived neurotrophic factor were also improved by low-frequency rTMS.Conclusions. Low-frequency rTMS had a neuroprotective effect on the nigral dopaminergic neuron which might be due to the improved expressions of brain derived neurotrophic factor and glial cell line-derived neurotrophic factor. The present study provided a theoretical basis for the application of low-frequency rTMS in the clinical treatment and recovery of Parkinson’s disease.

scholarly journals Low-Frequency Repetitive Transcranial Magnetic Stimulation over Right Dorsolateral Prefrontal Cortex in Parkinson’s Disease

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Sheng Zhuang ◽  
Fu-Yu Wang ◽  
Xin Gu ◽  
Jia-Jing Wu ◽  
Cheng-Jie Mao ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dorsolateral Prefrontal Cortex ◽  
Rating Scale ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Low Frequency ◽  
Nonmotor Symptoms ◽  
Dorsolateral Prefrontal ◽  
Low Frequency Rtms ◽  
Updrs Part

Background. Repetitive transcranial magnetic stimulation (rTMS) is a promising therapeutic tool for Parkinson’s disease (PD), and many stimulation targets have been implicated. We aim to explore whether low-frequency rTMS over the right dorsolateral prefrontal cortex (DLPFC) improves motor and nonmotor symptoms of individuals with PD. Methods. We conducted a randomized, single-blind, sham-controlled parallel trial to compare the effect of 10 consecutive daily sessions of 1 Hz rTMS over right DLPFC on individuals with idiopathic PD between active and sham rTMS group. Primary outcomes were changes in Unified Parkinson’s Disease Rating Scale (UPDRS) part III and Nonmotor Symptom Questionnaire (NMSQ). Secondary outcomes were changes in UPDRS total score, Hamilton Rating Scale for Depression (HRSD), Pittsburgh Sleep Quality Index (PSQI), and Montreal Cognitive Assessment (MoCA). Assessments were completed at baseline, after treatment, and at 1 month, 3 months, and 6 months after treatment. Results. A total of 33 participants with PD were randomized. All participants completed the study and no severe adverse effect was noticed. Compared to baseline, active rTMS showed significant improvements in UPDRS part III and NMSQ at 1 month. Change of scores on UPDRS part III, HRSD, and PSQI persisted for 3 months after rTMS intervention. The beneficial effect on cognitive performance assessed by MoCA was maintained for at least 6 months in the follow-up. No significant changes were observed in the group with sham rTMS. Conclusions. Low-frequency rTMS of right DLPFC could be a potential selection in managing motor and nonmotor symptoms in PD.

The influence of one session of low frequency rTMS on pre-supplementary motor area metabolites in late stage Parkinson's disease

2019 ◽  
Vol 130 (8) ◽  
pp. 1292-1298 ◽  
Author(s):  
Anja Flamez ◽  
Wietse Wiels ◽  
Peter Van Schuerbeek ◽  
Johan De Mey ◽  
Jacques De Keyser ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Late Stage ◽  
Supplementary Motor Area ◽  
Low Frequency ◽  
Motor Area ◽  
Low Frequency Rtms
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