scholarly journals Investigating the genesis of evoked responses by invasive electrophysiological recording and direct stimulation in the human brain

2021 ◽  
Vol 14 (6) ◽  
pp. 1685
Author(s):  
Hsin-Ju Lee ◽  
Wen-Jui Kuo ◽  
Hsing-Yu Yu ◽  
Chien-Chen Chou ◽  
Cheng-Chia Lee ◽  
...  
Keyword(s):  
Human Brain ◽  
Electrophysiological Recording ◽  
Evoked Responses ◽  
Direct Stimulation

Magnetic and electrical responses of the human brain to texture-defined form and to textons

1995 ◽  
Vol 74 (3) ◽  
pp. 1167-1178 ◽  
Author(s):  
D. Regan ◽  
P. He
Keyword(s):  
Human Brain ◽  
Neural Systems ◽  
Magnetic Response ◽  
Evoked Responses ◽  
Local Orientation ◽  
Brain Response ◽  
Check Size ◽  
Texture Discrimination ◽  
Texture Pattern ◽  
Brain Responses

1. We searched for a neurophysical correlate of preattentive texture discrimination by recording magnetic and electric evoked responses from the human brain during the first few hundred milliseconds following the presentation of texture-defined (TD) checkerboard form. The only two textons that changed when the TD checkerboard appeared or disappeared were the local orientation and line termination textons. (Textons are conspicuous local features within a texture pattern). 2. Our evidence that the magnetic response to TD form cannot be explained in terms of responses to the two associated textons is as follows: 1) by dissociating the two responses we showed that the magnetic response to TD form is almost entirely independent of the magnetic response to the local orientation texton; 2) a further distinction between the two responses is that their distributions over the head are different; and 3) the magnetic response to TD form differs from the magnetic response to the line termination texton in both distribution over the head and waveform. We conclude that this evidence identifies the existence of a brain response correlate of preattentive texture discrimination. 3. We also recorded brain responses to luminance-defined (LD) checkerboard form. Our grounds for concluding that magnetic brain responses to the onset of checkerboard form are generated by different and independent neural systems for TD and LD form are as follows: 1) magnetic responses to the onset of TD form and LD form had different distributions over the skull, had different waveforms, and depended differently on check size; and 2) the waveform of the response to superimposed TD and LD checks closely approximated the linear sum of responses to TD checks and LD checks alone. 4. One possible explanation for the observed differences between the magnetic and electric evoked responses is that responses to both onset and offset of TD form predominantly involve neurons aligned parallel to the skull, whereas that is not the case for responses to LD form.

Cerebral-Evoked Responses Elicited by Direct Stimulation of the Lateral Spinothalamic Tract in the Human

1985 ◽  
Vol 48 (1-6) ◽  
pp. 267-270 ◽  
Author(s):  
T. Taira ◽  
K. Amano ◽  
H. Kawamura ◽  
T. Tanikawa ◽  
K. Kitamura
Keyword(s):  
Evoked Responses ◽  
Direct Stimulation ◽  
Spinothalamic Tract ◽  
Stimulation Of

A novel mechanism for evoked responses in the human brain

2008 ◽  
Vol 69 (3) ◽  
pp. 214
Author(s):  
V.V. Nikulin ◽  
K. Linkenkaer-Hansen ◽  
G. Nolte ◽  
S. Lemm ◽  
K.R. Mueller ◽  
...  
Keyword(s):  
Human Brain ◽  
Evoked Responses

THE EFFECT OF HIGH DOSE PENTOBARBITAL ON HUMAN BRAIN STEM AUDITORY AND MEDIAN NERVE SOMATOSENSORY EVOKED RESPONSES

1986 ◽  
Vol 65 (Supplement 3A) ◽  
pp. A539 ◽  
Author(s):  
J C Drummond ◽  
M M Todd ◽  
A Schubert ◽  
H S U
Keyword(s):  
Human Brain ◽  
Brain Stem ◽  
Median Nerve ◽  
High Dose ◽  
Evoked Responses

scholarly journals Amygdala and hippocampus are symptomatogenic zones for central apneic seizures

Neurology ◽  
2017 ◽  
Vol 88 (7) ◽  
pp. 701-705 ◽  
Author(s):  
Nuria Lacuey ◽  
Bilal Zonjy ◽  
Luisa Londono ◽  
Samden D. Lhatoo
Keyword(s):  
Human Brain ◽  
Respiratory Control ◽  
Central Apnea ◽  
Direct Stimulation ◽  
Breathing Control ◽  
Expiratory Phase ◽  
Depth Electrodes ◽  
Hippocampal Seizures ◽  
Temporal Neocortex ◽  
Stimulation Of

Objective:To identify limbic sites of respiratory control in the human brain, and by extension, the symptomatogenic zone for central apnea.Methods:We used direct stimulation of anatomically, precisely placed stereotactic EEG electrodes to analyze breathing responses. We prospectively studied 3 patients who were explored with stereotactically implanted depth electrodes. The amygdala and hippocampus, as well as extralimbic sites (orbitofrontal, temporal tip, and temporal neocortex), were investigated.Results:Individual stimulation of the amygdala and hippocampal head consistently elicited central apnea in the expiratory phase, as did exquisitely focal hippocampal seizures.Conclusions:These findings confirm that hippocampus and amygdala are limbic breathing control sites in humans, as well as the symptomatogenic zone for central apneic seizures.

scholarly journals Human cerebrospinal fluid induces neuronal excitability changes in resected human neocortical and hippocampal brain slices

2019 ◽  
Author(s):  
Jenny Wickham ◽  
Andrea Corna ◽  
Niklas Schwarz ◽  
Betül Uysal ◽  
Nikolas Layer ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Human Brain ◽  
Brain Tissue ◽  
Ex Vivo ◽  
Brain Slices ◽  
Electrophysiological Recording ◽  
Recording Medium ◽  
Human Brain Tissue ◽  
Human Cerebrospinal Fluid

AbstractHuman cerebrospinal fluid (hCSF) have proven advantageous over conventional medium when culturing both rodent and human brain tissue. Increased excitability and synchronicity, similar to the active state exclusively recorded in vivo, reported in rodent slice and cell-cultures with hCSF as recording medium, indicates properties of the hCSF not matched by the artificial cerebrospinal fluid (aCSF) commonly used for electrophysiological recording. To evaluate the possible importance of using hCSF as electrophysiological recording medium of human brain tissue, we compared the general excitability in ex vivo human brain tissue slice cultures during perfusion with hCSF and aCSF. For measuring the general activity from a majority of neurons within neocortical and hippocampal human ex vivo slices we used a microelectrode array (MEA) recording technique with 252 electrodes covering an area of 3.2 x 3.2 mm2 and a second CMOS-based MEA with 4225 electrodes on a 2 x 2 mm2 area for detailed mapping of action potential waveforms. We found that hCSF increase the number of active neurons and the firing rate of the neurons in the slices as well as increasing the numbers of bursts while leaving the duration of the bursts unchanged. Interestingly, not only an increase in the overall activity in the slices was observed, but a reconfiguration of the network functionality could be detected with specific activation and inactivation of subpopulations of neuronal ensembles. In conclusion, hCSF is an important component to consider for future human tissue studies, especially for experiments designed to mimic the in vivo situation.

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