Aberrant behavior prediction and severity analysis for autistic child through deep transfer learning to avoid adverse drug effect

This short paper will briefly discuss the merits of determining plasma enzyme activities in pre-clinical safety evaluation. Emphasis is placed on the value of selecting the appropriate enzymes and collecting blood samples at the appropriate times during the study, so as to gain the maximum amount of diagnostic information. Examples of actual results will be cited to illustrate some of the points. These examples are drawn from the 2 commonly used toxicology species—the laboratory white rat and the beagle—and serve to demonstrate the importance of enzymology in monitoring the progress or resolution of an adverse drug effect.

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An Unexpected Adverse Drug Effect

Journal of Midwifery & Women s Health ◽

10.1016/s1526-9523(02)00361-6 ◽

2003 ◽

Vol 48 (1) ◽

pp. 67-68 ◽

Cited By ~ 3

Author(s):

Cara J. Krulewitch

Keyword(s):

Drug Effect ◽

Adverse Drug Effect

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Adverse Drug Effect—Reactive Metabolites and Idiosyncratic Drug Reactions: Part I

Annals of Pharmacotherapy ◽

10.1177/106002809202600317 ◽

1992 ◽

Vol 26 (3) ◽

pp. 416-421 ◽

Cited By ~ 5

Author(s):

Milo Gibaldi ◽

Milo Gibaldi

Keyword(s):

Drug Effect ◽

Adverse Drug Effect ◽

Reactive Metabolites ◽

Idiosyncratic Drug Reactions ◽

Drug Reactions

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Computational approaches to understand the adverse drug effect on potassium, sodium and calcium channels for predicting TdP cardiac arrhythmias

Journal of Molecular Graphics and Modelling ◽

10.1016/j.jmgm.2017.06.012 ◽

2017 ◽

Vol 76 ◽

pp. 152-160 ◽

Cited By ~ 3

Author(s):

Mohsen Sharifi

Keyword(s):

Calcium Channels ◽

Cardiac Arrhythmias ◽

Drug Effect ◽

Adverse Drug Effect ◽

Computational Approaches ◽

Potassium Sodium

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BERT based Adverse Drug Effect Tweet Classification

10.18653/v1/2021.smm4h-1.15 ◽

2021 ◽

Author(s):

Tanay Kayastha ◽

Pranjal Gupta ◽

Pushpak Bhattacharyya

Keyword(s):

Drug Effect ◽

Adverse Drug Effect ◽

Tweet Classification

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High Direct Bilirubin Associated With Levoffoxacin Use in a Neonate

The Journal of Pediatric Pharmacology and Therapeutics ◽

10.5863/1551-6776-25.1.64 ◽

2020 ◽

Vol 25 (1) ◽

pp. 64-67 ◽

Cited By ~ 1

Author(s):

Amy P. Holmes ◽

Charles E. Hartis ◽

Laurie J. Rollins

Keyword(s):

Successful Treatment ◽

Stenotrophomonas Maltophilia ◽

Drug Effect ◽

Premature Neonate ◽

Adverse Drug Effect ◽

Direct Bilirubin ◽

Limited Data ◽

Sharp Rise ◽

Neonatal Population

Limited data exist regarding the use of fluoroquinolones in the neonatal population. Levofloxacin has some utility in this population because it is one of a very limited number of antibiotics with activity against Stenotrophomonas maltophilia. We describe the successful treatment of S maltophilia tracheitis in a premature neonate using levofloxacin 10 mg/kg every 24 hours and the subsequent unexpected sharp rise in the direct bilirubin. This case illustrates a previously unrecognized adverse drug effect associated with levofloxacin use in neonates.

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