scholarly journals N6-methyladenosine modification regulates imatinib resistance of gastrointestinal stromal tumor by enhancing the expression of multidrug transporter MRP1

2022 ◽  
Author(s):  
Kangjing Xu ◽  
Qiang Zhang ◽  
Ming Chen ◽  
Bowen Li ◽  
Nuofan Wang ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Multidrug Transporter ◽  
Imatinib Resistance

Intracellular concentration and transporters in imatinib resistance of gastrointestinal stromal tumor

2019 ◽  
Vol 54 (2) ◽  
pp. 220-226 ◽  
Author(s):  
Qiang Zhang ◽  
Zheng Li ◽  
Kangjing Xu ◽  
Yi Qian ◽  
Ming Chen ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Intracellular Concentration ◽  
Stromal Tumor ◽  
Imatinib Resistance

Abstract 263: KITlowcells mediate Imatinib resistance and disease persistence in gastrointestinal stromal tumor

2019 ◽  
Author(s):  
Sudeep Banerjee ◽  
Chih-Min Tang ◽  
Mayra Yebra ◽  
Kwat Medetgul ◽  
Adam M. Burgoyne ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Imatinib Resistance ◽  
Disease Persistence

Emergence of Imatinib Resistance Associated with Downregulation of C-Kit Expression in Recurrent Gastrointestinal Stromal Tumor (GIST): Optimal Timing of Resection

2009 ◽  
Vol 14 (3) ◽  
pp. 557-561 ◽  
Author(s):  
Vikas Dudeja ◽  
Leonard H. Armstrong ◽  
Pankaj Gupta ◽  
Howard Ansel ◽  
Sabeen Askari ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Optimal Timing ◽  
Imatinib Resistance

scholarly journals Glucose transporter‑1 inhibition overcomes imatinib resistance in gastrointestinal stromal tumor cells

2021 ◽  
Vol 47 (1) ◽  
Author(s):  
Takafumi Shima ◽  
Kohei Taniguchi ◽  
Yoshihisa Tokumaru ◽  
Yosuke Inomata ◽  
Jun Arima ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Tumor Cells ◽  
Glucose Transporter ◽  
Stromal Tumor ◽  
Imatinib Resistance ◽  
Glucose Transporter 1

Abstract 263: KITlowcells mediate Imatinib resistance and disease persistence in gastrointestinal stromal tumor

2019 ◽  
Author(s):  
Sudeep Banerjee ◽  
Chih-Min Tang ◽  
Mayra Yebra ◽  
Kwat Medetgul ◽  
Adam M. Burgoyne ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Imatinib Resistance ◽  
Disease Persistence

Simultaneous gastrointestinal stromal tumor (GIST) and desmoid fibromatosis (DF)

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 10568-10568
Author(s):  
A. G. Dumont ◽  
D. Lev ◽  
A. Lazar ◽  
H. Joensuu ◽  
J. Trent
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Fibrous Tissue ◽  
Stromal Tumor ◽  
Cancer Center ◽  
Beta Catenin ◽  
Mesenchymal Tumors ◽  
Imatinib Resistance ◽  
Desmoid Fibromatosis ◽  
Number Of Patients ◽  
Patient Database

10568 Background: Desmoid Fibromatosis (DF) is one of a group of rare fibrous tissue proliferations (2–4 cases per year per million) which tend to be locally aggressive but have no propensity for metastasis. Gastrointestinal Stromal Tumor (GIST) is the most common mesenchymal tumors of the gastrointestinal tract and also rare (15–20 cases per year per million). Anecdotal reports of individuals with both diseases led us to investigate the number of patients at our institute with both types of cancer and their clinical, and histopathologic features. Methods: We identified four cases of GIST associated with DF at the M. D. Anderson Cancer Center between 1995 and 2008 using an IRB-approved protocol. Two more cases were identified from the patient database at the University of Helsinki. Results: Our patients were three men and three women aged from 39 to 66. Two patients were African Americans and 3 were Caucasians. In 5 cases, the GIST was diagnosed prior to the DF while one case had both tumors synchronous at presentation. The primary site of the GIST was gastric in 4 cases and the others were jejunal and mesenteric. Three patients had their DF occur in the surgical incision site mimicking a recurrence of GIST. The 3 others were intra-abdominal DF. There were no cases of DF occurring outside of the GI tract. One GIST patient was metastatic at presentation and one developed metastasis before DF was diagnosed. In 5 cases, imatinib mesylate was administered to the patients with partial response. In all cases KIT expression was observed immunohistochemically for GIST and but not for DF. Additionally, all cases of DF but no cases of GIST were found to have beta-catenin expression by immunohistochemistry. Conclusions: Our findings suggest that concurrent DF may occur in patients with GIST. Additionally, DF may mimic the recurrence of GIST or imatinib resistance. The association of these two sarcomas should be further explored. No significant financial relationships to disclose.

scholarly journals Imatinib resistance and microcytic erythrocytosis in a KitV558 ;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor

2012 ◽  
Vol 109 (34) ◽  
pp. E2276-E2283 ◽  
Author(s):  
B. Bosbach ◽  
S. Deshpande ◽  
F. Rossi ◽  
J.-H. Shieh ◽  
G. Sommer ◽  
...  
Keyword(s):  
Mouse Model ◽  
Gastrointestinal Stromal Tumor ◽  
Mutant Mouse ◽  
Stromal Tumor ◽  
Imatinib Resistance

scholarly journals Genome-scale CRISPR-Cas9 knockout screening in gastrointestinal stromal tumor with Imatinib resistance

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Jie Cao ◽  
Jianchang Wei ◽  
Ping Yang ◽  
Tong Zhang ◽  
Zhuanpeng Chen ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Imatinib Resistance ◽  
Genome Scale

KIT Low Cells Mediate Imatinib Resistance in Gastrointestinal Stromal Tumor

2021 ◽  
pp. molcanther.0973.2020
Author(s):  
Sudeep Banerjee ◽  
Hyunho Yoon ◽  
Stephanie Ting ◽  
Chih-Min Tang ◽  
Mayra Yebra ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Imatinib Resistance

scholarly journals RP11-616M22.7 recapitulates imatinib resistance in gastrointestinal stromal tumor

2021 ◽  
Author(s):  
Yebo Shao ◽  
Shixian Lian ◽  
Jiajia Zheng ◽  
Hanxing Tong ◽  
Jiongyuan Wang ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Imatinib Resistance
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