Albizia procera gum as an excipient for oral controlled release matrix tablet

2012 ◽  
Vol 90 (1) ◽  
pp. 289-295 ◽  
Author(s):  
Lalduhsanga Pachuau ◽  
Bhaskar Mazumder
Keyword(s):  
Controlled Release ◽  
Matrix Tablet ◽  
Albizia Procera

In vitro Controlled Release of two new Tuberculocidal Adamantane Aminoethers from Solid Pharmaceutical Formulations (II)

Drug Research ◽  
2017 ◽  
Vol 67 (11) ◽  
pp. 653-660 ◽  
Author(s):  
Marilena Vlachou ◽  
Angeliki Siamidi ◽  
Dimitrios Spaneas ◽  
Dimitrios Lentzos ◽  
Polixeni Ladia ◽  
...  
Keyword(s):  
Controlled Release ◽  
In Vitro Release ◽  
Pharmaceutical Formulations ◽  
Adamantane Derivative ◽  
In Vivo Studies ◽  
Matrix Tablet ◽  
The Us ◽  
Vitro Release

AbstractThe aim of the present investigation was to develop matrix tablet formulations for the in vitro controlled release of two new tuberculocidal adamantane aminoethers (compounds III and IV), congeneric to the adamantane derivative SQ109, which is in final clinical trials, and aminoethers (I) and (II), using carefully selected excipients, such as polyvinylpyrrolidone, sodium alginate and lactose. The tablets were prepared using the direct compression method and dissolution experiments were conducted using the US Pharmacopoeia type II apparatus (paddle method) in gastric and intestinal fluids. The results suggest that both analogues, albeit more lipophilic than SQ109, and aminoethers (I) and (II), have the requisite in vitro release characteristics for oral administration. In conclusion, these formulations merit further assessment by conducting in vivo studies, at a later stage.

scholarly journals Indomethacin Controlled Release Matrix Tablet Prepared by Wet Granulation Procedure.

1997 ◽  
Vol 45 (1) ◽  
pp. 214-216 ◽  
Author(s):  
Guojie XU ◽  
Hisakazu SUNADA ◽  
Ruhua ZHANG
Keyword(s):  
Controlled Release ◽  
Wet Granulation ◽  
Matrix Tablet

In vitro Controlled Release from Solid Pharmaceutical Formulations of two new Adamantane Aminoethers with Antitubercular Activity (I).

Drug Research ◽  
2017 ◽  
Vol 67 (08) ◽  
pp. 447-450 ◽  
Author(s):  
Marilena Vlachou ◽  
Angeliki Siamidi ◽  
Evanthia Diamantidi ◽  
Alexandra Iliopoulou ◽  
Ioannis Papanastasiou ◽  
...  
Keyword(s):  
Controlled Release ◽  
In Vitro Release ◽  
Antitubercular Activity ◽  
Pharmaceutical Formulations ◽  
Adamantane Derivative ◽  
In Vivo Studies ◽  
Matrix Tablet ◽  
The Us

AbstractThe aim of the present investigation was to develop matrix tablet formulations for the in vitro controlled release of 2 new tuberculocidal adamantane aminoethers (compounds I and II), congeneric to the adamantane derivative SQ109, which is in final clinical trials, using carefully selected excipients, such as polyvinylpyrrolidone, sodium alginate and lactose. The tablets were prepared using the direct compression method and dissolution experiments were conducted using the US Pharmacopoeia type II apparatus (paddle method) in gastric and intestinal fluids. The results confirm that both analogues, albeit more lipophilic than SQ109, showed satisfactory in vitro release characteristics from solid pharmaceutical formulations. In conclusion, these formulations merit further assessment by conducting in the future bioavailability in vivo studies.

An In Vitro Evaluation of Fenugreek Mucilage as a Potential Excipient for Oral Controlled-Release Matrix Tablet

2008 ◽  
Vol 34 (3) ◽  
pp. 323-329 ◽  
Author(s):  
Ali Nokhodchi ◽  
Hossein Nazemiyeh ◽  
Afagh Khodaparast ◽  
Tarifeh Sorkh-Shahan ◽  
Hadi Valizadeh ◽  
...  
Keyword(s):  
Controlled Release ◽  
Matrix Tablet ◽  
In Vitro Evaluation
Sign in / Sign up

Export Citation Format

Share Document