Formulation Development and In Vitro Evaluation of Controlled Release Matrix Tablet of Etodolac

2014 ◽  
Vol 47 (4) ◽  
pp. 39-48
Author(s):  
Krishna K. Panchal ◽  
Narendra P Chotai
Keyword(s):  
Controlled Release ◽  
Matrix Tablet ◽  
Formulation Development ◽  
In Vitro Evaluation

An In Vitro Evaluation of Fenugreek Mucilage as a Potential Excipient for Oral Controlled-Release Matrix Tablet

2008 ◽  
Vol 34 (3) ◽  
pp. 323-329 ◽  
Author(s):  
Ali Nokhodchi ◽  
Hossein Nazemiyeh ◽  
Afagh Khodaparast ◽  
Tarifeh Sorkh-Shahan ◽  
Hadi Valizadeh ◽  
...  
Keyword(s):  
Controlled Release ◽  
Matrix Tablet ◽  
In Vitro Evaluation

A controlled-release matrix tablet of furosemide: design, in vitro evaluation, pharmacological and pharmacodynamic evaluation

1988 ◽  
Vol 45 (1-2) ◽  
pp. 65-77 ◽  
Author(s):  
J. Verhoeven ◽  
L.J.C. Peschier ◽  
M. Danhof ◽  
H.E. Junginger
Keyword(s):  
Controlled Release ◽  
Matrix Tablet ◽  
In Vitro Evaluation

FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF FLOATING TABLETS OF LAFUTIDINE BY EMPLOYING EFFERVESCENT TECHNOLOGY

2017 ◽  
Vol 5 (2) ◽  
pp. 26-44
Author(s):  
Vageesh N.M ◽  
◽  
Sri Sura Ramya ◽  
Begum K Gulijar ◽  
Swathi B ◽  
...  
Keyword(s):  
Formulation Development ◽  
In Vitro Evaluation ◽  
Floating Tablets

Chitosan based Controlled Release Drug Delivery of Mycophenolate Mofetil Loaded in Nanocarriers System: Synthesis and in-vitro evaluation

2021 ◽  
pp. 1-18
Author(s):  
Muhammad Zaman ◽  
Asma Iqbal ◽  
Syed Farhan Haider Rizvi ◽  
Muhammad Ajaz Hussain ◽  
Talha Jamshaid ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mycophenolate Mofetil ◽  
Controlled Release ◽  
In Vitro Evaluation ◽  
System Synthesis ◽  
Release Drug

Preparation and in Vitro Evaluation of Controlled Release Dosage form of Indomethacin

1987 ◽  
Vol 13 (7) ◽  
pp. 1267-1278 ◽  
Author(s):  
Biswanath Sa ◽  
Suranjana Roy ◽  
Sudip K. Das
Keyword(s):  
Controlled Release ◽  
Dosage Form ◽  
In Vitro Evaluation

scholarly journals RANITIDINE CONTROLLED RELEASE ANTI-REFLUX SUSPENSION FOR GASTRO-OESOPHAGEAL REFLUX DISEASE AND IT’S IN VITRO EVALUATION

2019 ◽  
Vol 11 (1) ◽  
pp. 74
Author(s):  
Sangmesh R. Torne ◽  
Sheela A. ◽  
Sarada N. C.
Keyword(s):  
Controlled Release ◽  
Reflux Disease ◽  
Oesophageal Reflux ◽  
Gelling Agent ◽  
Acid Neutralizing Capacity ◽  
Simulated Gastric Fluid ◽  
In Vitro Evaluation ◽  
Oesophageal Reflux Disease ◽  
Neutralizing Capacity

Objective: The aim of this work was to develop triple action controlled release anti-reflux suspension of ranitidine and its in-vitro evaluation of anti-reflux and controlled release properties.Methods: The formulation was optimized using sodium alginate as a gelling agent along with calcium carbonate, sodium bicarbonate, magnesium hydroxide, aluminium hydroxide as alkalizing agents and colloidal microcrystalline cellulose (MCC) as a suspending agent at various concentrations and arrived at an optimized formulation for its best quality attributes. To avoid initial release in water before administration, ranitidine coated MCC sphere was incorporated into powder formulation and subjected to in vitro characteristics like raft strength, acid neutralizing capacity, pH, viscosity and dissolution study. The obtained results were assessed using Minitab 17 statistical software to conclude the study design.Results: Formulation containing 300 mg of ranitidine along with 750 mg alginate has shown better anti-reflux characteristics like raft strength 18±2g, acid neutralizing capacity 17±1 mEq compared to other formulations. This formulation has also shows zero-order controlled release in the simulated gastric fluid (SGF) up to 10 h compared to the formulation without alginate. Further, to this optimized formulation has shown negligible change in the assay of ranitidine even after 3 mo at 40 °C temperature and 75% RH.Conclusion: The developed stable sustained release powder for suspension has the combined therapeutic efficacy as an antacid and anti-reflux drug suitable for the management and treatment of gastro-oesophageal reflux disease (GERD) unlike the existing drugs possessing only reflux resistance action.

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