scholarly journals Injectable bone substitute based on chitosan with polyethylene glycol polymeric solution and biphasic calcium phosphate microspheres

2020 ◽  
Vol 245 ◽  
pp. 116575
Author(s):  
Daniel Bezerra Lima ◽  
Mônica Adriana Araújo de Souza ◽  
Gabriel Goetten de Lima ◽  
Erick Platiní Ferreira Souto ◽  
Hugo Miguel Lisboa Oliveira ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Calcium Phosphate ◽  
Bone Substitute ◽  
Biphasic Calcium Phosphate ◽  
Polymeric Solution

scholarly journals Biphasic calcium phosphate as a bone substitute

2016 ◽  
Vol 4 ◽  
Author(s):  
Pluta Klaudia ◽  
Walczyk Dorota ◽  
Sobczak-Kupiec Agnieszka ◽  
Malina Dagmara ◽  
Tyliszczak Bozena
Keyword(s):  
Calcium Phosphate ◽  
Bone Substitute ◽  
Biphasic Calcium Phosphate

Fully Interconnected Globular Porous Biphasic Calcium Phosphate Ceramic Scaffold Facilitates Osteogenic Repair

2007 ◽  
Vol 361-363 ◽  
pp. 119-122 ◽  
Author(s):  
J.H. Lim ◽  
J.H. Park ◽  
Eui Kyun Park ◽  
Hae Jung Kim ◽  
Il Kyu Park ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Substitute ◽  
Biphasic Calcium Phosphate ◽  
Bone Defects ◽  
Calcium Phosphate Ceramic ◽  
Ceramic Scaffold ◽  
Porous Biphasic Calcium Phosphate

An appropriate scaffold, which provides structural support for transplanted cells and acts as a vehicle for the delivery of biologically active molecules, is critical for tissue engineering. We developed a fully interconnected globular porous biphasic calcium phosphate ceramic scaffold by adopting a foaming method, and evaluated its efficiency as a bone substitute and a scaffold for bone tissue engineering by in vitro and in vivo biocompatible analysis and its osteogenic healing capacity in rat tibial bone defects. They have spherical pores averaging 400um in diameter and interconnecting interpores averaging 70um in diameter with average 85% porosity. They elicited no cytotoxicity and noxious effect on cellular proliferation and osteoblastic differentiation during the cell-scaffold construct formation. Also the bone defects grafted with fully interconnected globular porous biphasic calcium phosphate ceramic blocks revealed excellent bone healing within 3 weeks. These findings suggest that the fully interconnected porous biphasic calcium phosphate scaffold formed by the foaming method can be a promising bone substitute and a scaffold for bone tissue engineering.

scholarly journals In vivo graft performance of an improved bone substitute composed of poor crystalline hydroxyapatite based biphasic calcium phosphate

2011 ◽  
Vol 30 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Ching-Lien HUNG ◽  
Jen-Chang YANG ◽  
Wei-Jen CHANG ◽  
Chih-Yuan HU ◽  
Yong-Ho LIN ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Substitute ◽  
Biphasic Calcium Phosphate

Randomized clinical trial for the biological evaluation of two nanostructured biphasic calcium phosphate biomaterials as a bone substitute

2017 ◽  
Vol 19 (5) ◽  
pp. 802-811 ◽  
Author(s):  
Marcelo José Uzeda ◽  
Rodrigo Figueiredo de Brito Resende ◽  
Suelen Cristina Sartoretto ◽  
Adriana Terezinha Neves Novellino Alves ◽  
José Mauro Granjeiro ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Calcium Phosphate ◽  
Randomized Clinical Trial ◽  
Bone Substitute ◽  
Biphasic Calcium Phosphate ◽  
Biological Evaluation

Modification of gene expression induced in human osteogenic and osteosarcoma cells by culture on a biphasic calcium phosphate bone substitute

Bone ◽  
2003 ◽  
Vol 32 (6) ◽  
pp. 602-610 ◽  
Author(s):  
N Rochet ◽  
A Loubat ◽  
J.-P Laugier ◽  
P Hofman ◽  
J.M Bouler ◽  
...  
Keyword(s):  
Gene Expression ◽  
Calcium Phosphate ◽  
Bone Substitute ◽  
Biphasic Calcium Phosphate ◽  
Osteosarcoma Cells
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