An update on microcrystalline cellulose in direct compression: Functionality, critical material attributes, and co-processed excipients

Microcrystalline cellulose (MCC) is a versatile and frequently used material in different industries such as pharmaceutals production, medical, cosmetics and food industry. It is inert, economic, compatibility, compatibility, non-toxicity, biodegradability, good mechanical properties, high surface area, variety and availability of different grades and biocompatibility has made it very popular. A number of research has been done on MCC to isolate it from different plant sources that are economical and eco-friendly. MCC is extracted from α cellulose that is abundant in nature as most of MCC is produced from wood. However, new eco-friendly sources with changes in methods of isolation have been applied for the production of MCC. In this review MCC isolated from different plant-based resources, extraction process parameters, origin of raw material and its influence on critical material attributes of MCC has been outlined and discussed thoroughly. Since these critical material attributes have a significant effect on tablet making process parameters (compressibility, compactibility and etc) and its post compression characters.Keywords: Microcrystalline cellulose, isolation, characterization, raw material, tablet

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Optimization of Microcrystalline Cellulose PH 101, Lactose, and Kollidon® K 30 To Obtain Co-Processed Excipient Through Spray Drying

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v7i2.8921 ◽

2017 ◽

Vol 7 (2) ◽

Author(s):

Kusuma P. ◽

Syukri Y ◽

Sholehuddin F. ◽

Fazzri N. ◽

Romdhonah . ◽

...

Keyword(s):

Spray Drying ◽

Microcrystalline Cellulose ◽

Chemical Change ◽

Direct Compression ◽

Flow Properties ◽

Scanning Calorimetry ◽

Compression Process ◽

Infrared Spectrophotometer ◽

Physical Mixtures ◽

Spray Dried

The most efficient tablet processing method is direct compression. For this method, the filler-binder can be made by coprocessing via spray drying method. The purpose of this study was to investigate the effect of spray dried co-processing on microcrystalline cellulose (MCC) PH 101, lactose and Kollidon® K 30 as well as to define the optimum proportions. Spray dried MCC PH 101, lactose, and Kollidon® K 30 were varied in 13 different mixture design proportions to obtain compact, free-flowing filler-binder co-processed excipients (CPE). Compactibility and flow properties became the key parameters to determine the optimum proportions of CPE that would be compared to their physical mixtures. The result showed that the optimum proportion of CPE had better compactibility and flow properties than the physical mixtures. The optimum CPE, consisting of only MCC PH 101 and Kollidon® K 30 without lactose, that were characterized using infrared spectrophotometer, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscope (SEM) indicated no chemical change therein. Therefore, this study showed that spray dried MCC PH 101, lactose and Kollidon® K 30 could be one of the filler-binder alternatives for direct compression process.

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