spray drying
Recently Published Documents





2022 ◽  
Vol 125 ◽  
pp. 107430
Jelena Bajac ◽  
Branislava Nikolovski ◽  
Ivana Lončarević ◽  
Jovana Petrović ◽  
Branimir Bajac ◽  

2022 ◽  
Vol 116 (1) ◽  
pp. 28-34
Jakub Karas ◽  
David Vetchý ◽  
Jan Gajdziok

The deposition of a drug to its required destination is crucial for effective lung treatment. It is important to design a suitable formulation that delivers the active ingredient to the desired site and resists the natural cleansing mechanisms of the airways. Large porous particles used as active substance carriers appear to be the most effective option for lung drug delivery. The present article provides a basic overview of the mechanisms of deposition of dry inhalable powders and methods of their preparation and evaluation. Spray drying together with micronization and crystallization techniques are among the most used methods of preparation of the discussed particles. Besides, these techniques can be combined with other production processes (encapsulation, emulsification, etc.). The evaluation of the properties of particles suitable for pulmonary application is based on specific requirements for their density, porosity, shape, aerodynamic parameters, and deposition in the lungs, which can now be simulated on an accurate model of artificial lungs.

Small ◽  
2022 ◽  
pp. 2105761
Yubai Zhang ◽  
Jiadong Qin ◽  
Munkhbayar Batmunkh ◽  
Wei Li ◽  
Huaiqin Fu ◽  

Polymers ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 310
María Carolina Otálora ◽  
Andrea Wilches-Torres ◽  
Jovanny A. Gómez Castaño

In this work, the capacity of the mucilage extracted from the cladodes of Opuntia ficus-indica (OFI) and aloe vera (AV) leaves as wall material in the microencapsulation of pink guava carotenoids using spray-drying was studied. The stability of the encapsulated carotenoids was quantified using UV–vis and HPLC/MS techniques. Likewise, the antioxidant activity (TEAC), color (CIELab), structural (FTIR) and microstructural (SEM and particle size) properties, as well as the total dietary content, of both types of mucilage microcapsules were determined. Our results show that the use of AV mucilage, compared to OFI mucilage, increased both the retention of β-carotene and the antioxidant capacity of the carotenoid microcapsules by around 14%, as well as the total carotenoid content (TCC) by around 26%, and also favors the formation of spherical-type particles (Ø ≅ 26 µm) without the apparent damage of a more uniform size and with an attractive red-yellow hue. This type of microcapsules is proposed as a convenient alternative means to incorporate guava carotenoids, a natural colorant with a high antioxidant capacity, and dietary fiber content in the manufacture of functional products, which is a topic of interest for the food, pharmaceutical, and cosmetic industries.

Molecules ◽  
2022 ◽  
Vol 27 (2) ◽  
pp. 496
Christopher Hernandez ◽  
Laura Cadenillas ◽  
Céline Mathieu ◽  
Jean-Denis Bailly ◽  
Vanessa Durrieu

Mimosa tenuiflora aqueous extract (MAE) is rich in phenolic compounds. Among them, condensed tannins have been demonstrated to exhibit a strong antioxidant and antiaflatoxin B1 activities in Aspergillus flavus. Since antioxidant capacity can change with time due to environmental interactions, this study aimed to evaluate the ability of encapsulation by spray-drying of Mimosa tenuiflora aqueous extract to preserve their biological activities through storage. A dry formulation may also facilitate transportation and uses. For that, three different wall materials were used and compared for their efficiency. Total phenolic content, antioxidant activity, antifungal and antiaflatoxin activities were measured after the production of the microparticles and after one year of storage at room temperature. These results confirmed that encapsulation by spray-drying using polysaccharide wall materials is able to preserve antiaflatoxin activity of Mimosa tenuiflora extract better than freezing.

2022 ◽  
Vol 4 (3) ◽  
pp. 107
Nurwanto Nurwanto

Sari pandan merupakan hasil ekstraksi daun pandan. Sari pandan siap pakai yang beredar di Indonesia mayoritas berbentuk pasta, yang memiliki beberapa kelemahan, diantaranya mudah rusak, lengket, dan susah ditakar. Pembuatan sari pandan dalam bentuk bubuk diharapkan dapat meningkatkan mutu sari pandan. Metode yang digunakan dalam penelitian ini adalah pengeringan spray drying dan pengeringan vakum. Pengujian kadar air menunjukkan bahwa sari pandan yang dibuat dengan metode spray drying memiliki kadar air yang lebih rendah daripada metode pengeringan vakum. Pengamatan sifat fisik sari pandan dalam kondisi siap pakai menunjukkan bahwa metode spray drying menghasilkan warna dan aroma sari pandan yang lebih kuat daripada metode pengeringan vakum. Uji organoleptik menunjukkan bahwa panelis lebih menyukai warna dan aroma sari pandan yang dibuat dengan metode spray drying. Pandan extracts is made from pandan leaves. The majority of ready-to-use pandan extracts in Indonesia are in the form of pasta which has several disadvantages, including perishable, sticky, and hard to be measured. Pandan extract in powder form is expected to improve the quality of the pandan extract. The method used in this study are spray drying and vacuum drying. Water content analysis shows that pandan extract made by spray drying method has a lower moisture content than the vacuum drying method. Observation of the physical properties of pandan extract in ready-to-use form showed that the spray drying method produced stronger color and aroma than the vacuum drying  method. Organoleptic tests showed that panelists preferred the color and aroma of pandan extract made using the spray drying method.


Objective: This research aimed to prepare curcumin microcapsules by the spray drying method and to evaluate their characteristics. Methods: The microcapsules were prepared by the spray drying method. The generated microcapsules were evaluated for organoleptic, morphology, particle size, the percentage of curcumin and water content. Furthermore, the release of curcumin from the microcapsules was tested in vitro and compared to uncoated curcumin powder. In addition, the mucoadhesive properties of uncoated curcumin powder and curcumin microcapsules were also evaluated. Results: The results showed that the microcapsules had spherical shape with particle size in the range of 100–1009 µm and water content of 9.34% (w/w) (FIII) and 8.09% (w/w) (FVI). The release of curcumin from its uncoated powder and the microcapsules FVI within 8 h were 8.87% and 26.32% (w/w), respectively. It was found that the mucoadhesive properties of microcapsules FVI were better than those of FIII and uncoated curcumin powder. Microcapsules FVI rendered the cumulative amount of curcumin remaining on the intestinal mucosa of 55% (w/w) within 3 h. Conclusion: Accordingly, curcumin microcapsules generated by spray drying could be further formulated into various solid dosage forms for a better therapeutic effect.

LWT ◽  
2022 ◽  
Vol 153 ◽  
pp. 112495
Travis G. Burger ◽  
Indarpal Singh ◽  
Caleb Mayfield ◽  
Joseph L. Baumert ◽  
Yue Zhang

Sign in / Sign up

Export Citation Format

Share Document