Aims and Objective:
Synthesis of novel bis-spirooxindoles was carried out from isatins, two equivalents of malononitrile and various derivatives of cyclohexanones.
Background :
A facile one-pot and four-component reaction was investigated for the synthesis of novel bis-spirooxindoles
from different derivatives of isatins, two equivalents of malononitrile and various derivatives of cyclohexanone in the presence
of magnetic CoFe2O4@MCM-41@MgO NPS catalyst under mild condition.
Materials and Methods:
Firstly, the magnetic CoFe2O4@MCM-41@MgO was prepared during three steps. Afterward, the
CoFe2O4@MCM-41@MgO was used as a base catalyst for one-pot synthesis of bis-spirooxindoles.
Results and Discussion:
The procedure exhibited several benefits, excellent yield of products, short reaction times, reusability
and recyclability of the nanocatalyst.
Conclusion:
The structure of nanocatalyst was recognized by FT-IR, XRD, VSM, SEM, BET and EDX techniques, and the
structure of the organic products was determined with melting point, FT-IR, 1H NMR, 13C NMR, Mass spectra and C.H.N
analyses.
Nanocrystalline magnesium oxide as solid base catalyst in the presence of iodine promoted one-pot synthesis of 2-substituted benzimidazole derivatives under mild conditions