Synthesis of novel bis-spirooxindoles catalyzed by magnetic cobalt ferrite encapsulated MCM-41@MgO as a solid base

2020 ◽  
Vol 17 ◽  
Author(s):  
Somaye Mohammadi ◽  
Hossein Naeimi
Keyword(s):  
Mass Spectra ◽  
Cobalt Ferrite ◽  
Reaction Times ◽  
Solid Base ◽  
Base Catalyst ◽  
One Pot ◽  
Organic Products ◽  
Ft Ir ◽  
Derivatives Of ◽  
Mcm 41

Aims and Objective: Synthesis of novel bis-spirooxindoles was carried out from isatins, two equivalents of malononitrile and various derivatives of cyclohexanones. Background : A facile one-pot and four-component reaction was investigated for the synthesis of novel bis-spirooxindoles from different derivatives of isatins, two equivalents of malononitrile and various derivatives of cyclohexanone in the presence of magnetic CoFe2O4@MCM-41@MgO NPS catalyst under mild condition. Materials and Methods: Firstly, the magnetic CoFe2O4@MCM-41@MgO was prepared during three steps. Afterward, the CoFe2O4@MCM-41@MgO was used as a base catalyst for one-pot synthesis of bis-spirooxindoles. Results and Discussion: The procedure exhibited several benefits, excellent yield of products, short reaction times, reusability and recyclability of the nanocatalyst. Conclusion: The structure of nanocatalyst was recognized by FT-IR, XRD, VSM, SEM, BET and EDX techniques, and the structure of the organic products was determined with melting point, FT-IR, 1H NMR, 13C NMR, Mass spectra and C.H.N analyses.

One-pot synthesis of calcium-incorporated MCM-41 as a solid base catalyst for transesterification of palm olein

2011 ◽  
Vol 16 (1) ◽  
pp. 25-29 ◽  
Author(s):  
Jonggol Tantirungrotechai ◽  
Pharawee Thananupappaisal ◽  
Boonyawan Yoosuk ◽  
Nawin Viriya-empikul ◽  
Kajornsak Faungnawakij
Keyword(s):  
Palm Olein ◽  
Solid Base ◽  
Base Catalyst ◽  
Solid Base Catalyst ◽  
One Pot ◽  
One Pot Synthesis ◽  
Mcm 41

scholarly journals Synthesis of new bimetallic phosphate (Al/Ag3PO4) and study for its Catalytic performance in the synthesis of 1,2-dihydro-l-phenyl-3H-naphth [1,2-e]-[1,3] oxazin-3-one derivatives

2021 ◽  
Vol 11 (3) ◽  
pp. 215
Author(s):  
Achraf El Hallaoui ◽  
Tourya Ghailane ◽  
Soukaina Chehab ◽  
Youssef Merroun ◽  
Rachida Ghailane ◽  
...  
Keyword(s):  
Reaction Times ◽  
Catalytic Performance ◽  
X Ray Diffraction ◽  
One Pot ◽  
X Ray ◽  
Silver Sulfate ◽  
Triple Super Phosphate ◽  
Aryl Aldehyde ◽  
Ft Ir ◽  
First Time

<p>This work aims to prepare a new bimetallic phosphate catalyst using a new simple and effective method. This new catalyst was ready for the first time by a modification of Triple Super Phosphate (TSP) fertilizer with silver sulfate (AgSO<sub>4</sub>), followed by the impregnation of the aluminum atoms using aluminum nitrate (Al(NO<sub>3</sub>)<sub>3</sub>). The use of Al/Ag<sub>3</sub>PO<sub>4</sub>, for the first time as a heterogeneous catalyst in organic chemistry, offers a new, efficient, and green pathway for synthesizing 1,2-dihydro-l-phenyl-3H-naphth[1,2-e]-[1,3]oxazin-3-one derivatives by one-pot three-component cyclocondensation of b-naphthol, aryl aldehyde, and urea. The structure and the morphology of the prepared catalyst were characterized by spectroscopic methods such as X-Ray Diffraction (XRD), Fourier Transform Infrared spectroscopy (FT-IR), and dispersive X-ray spectrometry coupled with a scanning electron microscope (EDX-SEM). In addition, the optimization of the reaction parameters was carried out considering the effect of catalyst amount, the temperature, and the solvent. The procedure described herein allowed a comfortable preparation of oxazine derivatives with excellent yields, short reaction times, and in the absence of organic solvent.</p>

scholarly journals A One-Pot Three-Component Synthesis and Investigation of the In Vitro Mechanistic Anticancer Activity of Highly Functionalized Spirooxindole-Pyrrolidine Heterocyclic Hybrids

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5581
Author(s):  
Raju Suresh Kumar ◽  
Dhaifallah M. Al-thamili ◽  
Abdulrahman I. Almansour ◽  
Natarajan Arumugam ◽  
Faruq Mohammad
Keyword(s):  
Anticancer Activity ◽  
Anticancer Agents ◽  
One Pot ◽  
Major Pathway ◽  
Molecular Scaffold ◽  
Highly Active ◽  
Ft Ir ◽  
Derivatives Of ◽  
Unique Mechanism

With an aim to develop more effective and affordable anticancer agents possessing a unique mechanism of action, we designed and synthesized derivatives of spirooxindole-pyrrolidine heterocyclic hybrids in good yields through a one-pot three-component (3+2) cycloaddition strategy. The synthesized compounds were characterized thoroughly for the physicochemical properties by making use of FT-IR, NMR spectroscopy, and mass spectrometry. Further, these compounds have been evaluated for the influence of anticancer activity against HepG2 cells up to 200 µg/mL concentration. The highly active molecular scaffold was tested for the in-depth mechanistic studies, and it was found that the major pathway of cell death is apoptosis which occurs through the induction of reactive oxygen species followed by the involvement of caspases.

scholarly journals Synthesis and antimicrobial screening of pyrano[3,2-c]chromene derivatives of 1H-pyrazoles

2011 ◽  
Vol 9 (4) ◽  
pp. 635-647 ◽  
Author(s):  
Chetan Sangani ◽  
Divyesh Mungra ◽  
Manish Patel ◽  
Ranjan Patel
Keyword(s):  
Antifungal Activity ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Fungal Pathogens ◽  
Broth Microdilution ◽  
One Pot ◽  
E Coli ◽  
Cyclocondensation Reaction ◽  
Ft Ir ◽  
Derivatives Of

AbstractA new series of twenty four derivatives of pyrano[3,2-c]chromene IVa-x bearing 1H-pyrazole were synthesized by a one pot, base-catalyzed cyclocondensation reaction of 1H-pyrazole-4-carbaldehyde Ia-l, malononitrile II and 4-hydroxycoumarin IIIa-b. All the synthesized compounds were characterized by elemental analysis, FT-IR, 1H NMR and 13C NMR spectral data. All the synthesized compounds were screened against six bacterial pathogens, namely B. subtilis, C. tetani, S. pneumoniae, S. typhi, V. cholerae, E. coli and for antifungal activity against two fungal pathogens, A. fumigatus and C. albicans using the broth microdilution MIC method. Some of the compounds were found to be equipotent or more potent than commercial drugs against most of employed strains, as evident from the screening data.

NiFe2O4@SiO2 @amino Glucose Magnetic Nanoparticle under Solvent-free Condition: A New, mild, Simple and Effective Avenue for the Synthesis of Quinazolinone, Imidazo[1,2-a]Pyrimidinone and Novel Derivatives of Amides

2020 ◽  
Vol 17 (4) ◽  
pp. 304-312
Author(s):  
Leila Z. Fekri
Keyword(s):  
Reaction Times ◽  
Solvent Free ◽  
Environmentally Benign ◽  
Multicomponent Synthesis ◽  
Solvent Free Condition ◽  
Amide Derivatives ◽  
Solvent Free Conditions ◽  
Ft Ir ◽  
First Time ◽  
Derivatives Of

Background: Imidazo[1,2-a]pyrimidinone, quinazolinone and amide derivatives have attracted a lot of interest because of their broad scope of biological and pharmacological activities. There are a lot of methods reported in the literature for their synthesis. Therefore, we became interested in developing a convenient synthetic method for the preparation of imidazoquinazolinone and amide derivatives. Objective: NiFe2O4@SiO2 @glucose amine were synthesized, characterized and have been used for the green, effective and mild multicomponent synthesis of quinazolinones, benzoimidazo[1,2-a]pyrimidinones and amides under solvent-free conditions in short reaction times and excellent yields. To expand of the scope of this avenue, multicomponent synthesis of mono and bis novel amides was tested for the first time. All of the products were characterized by mp, FT-IR, NMR and elemental analysis. Methods: Aldehyde (1mmol), 2-amino benzimidazole (1 mmol), dimedone (1mmol) or indane-1,3-dione (1 mmol) for the synthesis of quinazoline or imidazopyrimidinones and arene (1mmol), anhydride (1mmol), 2- aminobenzimidazole (1mmol) for the synthesis of amides in the nanocatalyst NiFe2O4@SiO2@glucose amine (0.15mol%: 0.05g) were stirred by a magnet for the required reaction time. After completion of the reaction, as indicated by TLC, the products were collected and recrystallized from ethanol if necessary. Results: We present a novel avenue for the synthesis of benzimidazo[1,2-a] pyrimidinones, quinazolinones and amides in the presence of NiFe2O4@SiO2@glucose amine under solvent-free conditions. Conclusion: In conclusion, we developed NiFe2O4@SiO2 @glucose amine-catalysed multicomponent synthesis of quinazolinones and imidazo[1,2-a]pyrimidinones using the reaction of benzaldehyde, dimedone or indane-dione and 2-aminobenzimidazole and multicomponent synthesis of amides using arenes, cyclic anhydrides and 2-aminobenzimidazole by a solvent-free technique. This method proves to be a robust and innovative approach for the synthesis of a biologically important structure. The operational simplicity, the excellent yields of products, ease of separation and recyclability of the magnetic catalyst, waste reduction and high selectivity are the main advantages of this method. Furthermore, this new avenue is cheap and environmentally benign.

scholarly journals N-phenyl-6-chloro-4-hydroxy-2-quinolone-3-carboxamides: Molecular Docking, Synthesis, and Biological Investigation as Anticancer Agents

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 73
Author(s):  
Dima A. Sabbah ◽  
Rawan A. Haroon ◽  
Sanaa K. Bardaweel ◽  
Rima Hajjo ◽  
Kamal Sweidan
Keyword(s):  
Anticancer Agents ◽  
Mass Spectra ◽  
Colorectal Adenocarcinoma ◽  
Phosphatidylinositol 3 Kinase ◽  
Induced Fit Docking ◽  
Biological Investigation ◽  
Hct 116 ◽  
Ft Ir ◽  
Binding Residues ◽  
Derivatives Of

Cancer is a multifactorial disease and the second leading cause of death worldwide. Diverse factors induce carcinogenesis, such as diet, smoking, radiation, and genetic defects. The phosphatidylinositol 3-kinase (PI3Kα) has emerged as an attractive target for anticancer drug design. Eighteen derivatives of N-phenyl-6-chloro-4-hydroxy-2-quinolone-3-carboxamide were synthesized and characterized using FT-IR, NMR (1H and 13C), and high-resolution mass spectra (HRMS). The series exhibited distinct antiproliferative activity (IC50 µM) against human epithelial colorectal adenocarcinoma (Caco-2) and colon carcinoma (HCT-116) cell lines, respectively: compounds 16 (37.4, 8.9 µM), 18 (50.9, 3.3 µM), 19 (17.0, 5.3 µM), and 21 (18.9, 4.9 µM). The induced-fit docking (IFD) studies against PI3Kαs showed that the derivatives occupy the PI3Kα binding site and engage with key binding residues.

scholarly journals Extending the Hierarchy of Heterogeneous Catalysis to Substituted Derivatives of Benzimidazole Synthesis: Transition Metals Decorated CNTs

Catalysts ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 1000
Author(s):  
Iqbal ◽  
Sadiq ◽  
Sadiq ◽  
Ullah ◽  
Fazal ◽  
...  
Keyword(s):  
Bimetallic Nanoparticles ◽  
Bet Surface Area ◽  
High Yield ◽  
Benzimidazole Derivatives ◽  
One Pot ◽  
X Ray ◽  
Practical Procedure ◽  
Molecular Reactivity ◽  
Ft Ir ◽  
Derivatives Of

A simple and practical procedure has been adopted for one pot synthesis of benzimidazole derivatives under mild reaction conditions, starting from cinnamyl alcohol (COH) with bimetallic nanoparticles (BNPs) and supported bimetallic nanoparticles of Cu, Ti, Zn, Mn, Ag, and Co. All the catalysts were characterized by Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDX), X-Ray Diffractometry (XRD), Brunauer Emmett-Teller (BET) surface area, and pore size analyzer. The products were identified/quantified with 1HNMR, FT-IR, and MS. 98% yield of substituted derivatives of benzimidazole was obtained with Cu–Ti supported on FMWCNTs in ethanol with excellent selectivity. Quantum chemical calculations of molecular reactivity of substituted cinnamaldehyde (CHO) and ortho phenylenediamine (OPD) have good consistency with experimental results. The returns of this work were the use of readily available catalysts, high yield, short reaction time, and simplicity of the process.

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