scholarly journals The genomes of the South American opossum (Monodelphis domestica) and platypus (Ornithorhynchus anatinus) encode a more complete purine catabolic pathway than placental mammals

Author(s):  
Alaine C. Keebaugh ◽  
James W. Thomas
2007 ◽  
Vol 116 (1-2) ◽  
pp. 130-131 ◽  
Author(s):  
B.R. Lawton ◽  
C. Obergfell ◽  
R.J. O’Neill ◽  
M.J. O’Neill

1997 ◽  
Vol 34 (4) ◽  
pp. 346-350 ◽  
Author(s):  
D. F. Kusewitt ◽  
K. B. Miska ◽  
R. D. Ley

S-100 immunoreactivity was determined 1) in foci of melanocytic hyperplasia, 2) in naturally occurring, ultraviolet radiation-induced, and 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced primary melanomas, and 3) in metastatic melanoma lesions in the South American opossum Monodelphis domestica. Preneoplastic lesions of melanocytic hyperplasia contained scattered cells with S-100-positive nuclei. All primary melanomas, with the exception of a single DMBA-induced tumor, contained cells with S-100-positive nuclei. The pattern of S-100 reactivity in tumors varied from large foci of S-100-positive cells to scattered individual S-100-positive cells. Lymph node metastases were S-100 positive, but metastatic masses in internal organs were usually S-100 negative. Although S-100 reactivity did not distinguish preneoplastic lesions from tumors or benign melanomas from malignant melanomas, identification of metastatic tumor cells clearly demonstrated malignancy.


1990 ◽  
Vol 27 (1) ◽  
pp. 66-68 ◽  
Author(s):  
D. F. Kusewitt ◽  
L. A. Applegate ◽  
C. D. Bucana ◽  
R. D. Ley

2003 ◽  
Vol 89 (4) ◽  
pp. 870-871 ◽  
Author(s):  
L. E O. Yai ◽  
W. A. Cañon-Franco ◽  
V. C. Geraldi ◽  
M. E L. Summa ◽  
M. C G. O. Camargo ◽  
...  

1994 ◽  
Vol 6 (4) ◽  
pp. 529 ◽  
Author(s):  
PG Johnston ◽  
D Dean ◽  
JL VandeBerg ◽  
ES Robinson

Marsupial females show preferential paternal X-inactivation. However, the time at which X-inactivation occurs in early development has not yet been determined. A double microassay which measures the activities of X-linked hypoxanthine phosphoribosyl transferase (HPRT) and the autosomally-coded adenine phosphoribosyl transferase (APRT) from the same sample was performed on a collection of embryos from a South American opossum Monodelphis domestica. The embryos ranged in age from the 2-cell stage to the bilaminar blastocyst stage. The results indicate that their embryonic HPRT and APRT are not expressed until just before the unilaminar blastocyst stage in M. domestica. This is at a later stage of development than that in the mouse where embryonic HPRT and APRT expression first occurs at the 4-8-cell stage. It is concluded that HPRT is an uniformative enzyme for assessing X chromosome activity in cleaving embryos of M. domestica. The widespread distribution of HPRT:APRT ratios after the unilaminar blastocyst stage also makes it difficult to draw conclusions about the state of X chromosome activity in early marsupial development.


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