PAR1, a therapeutic target for remote lung injury associated with hind limb ischemia/reperfusion: ERK5/KLF2-dependent lung capillary barrier preservation

2022 ◽  
pp. 109809
Author(s):  
Nada M. Kamel ◽  
Dalia M. El-Tanbouly ◽  
Dalaal M. Abdallah ◽  
Helmy M. Sayed
Keyword(s):  
Lung Injury ◽  
Therapeutic Target ◽  
Hind Limb ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Dependent Lung ◽  
Capillary Barrier ◽  
Hind Limb Ischemia

scholarly journals WITHDRAWN: Melatonin attenuates lung injury in a hind limb ischemia–reperfusion rat model

2014 ◽  
Author(s):  
Hamed Takhtfooladi ◽  
Mohammad Takhtfooladi ◽  
Fariborz Moayer ◽  
Sayed Mobarakeh
Keyword(s):  
Lung Injury ◽  
Rat Model ◽  
Hind Limb ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Hind Limb Ischemia

scholarly journals Effects of N-acetylcysteine and pentoxifylline on remote lung injury in a rat model of hind-limb ischemia/reperfusion injury

2016 ◽  
Vol 42 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Hamed Ashrafzadeh Takhtfooladi ◽  
Saeed Hesaraki ◽  
Foad Razmara ◽  
Mohammad Ashrafzadeh Takhtfooladi ◽  
Hadi Hajizadeh
Keyword(s):  
Superoxide Dismutase ◽  
Lung Injury ◽  
Hind Limb ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
The Other ◽  
Superoxide Dismutase Activity ◽  
Sham Operation ◽  
Hind Limb Ischemia ◽  
Remote Organ

Objective : To investigate the effects of N-acetylcysteine (NAC) and pentoxifylline in a model of remote organ injury after hind-limb ischemia/reperfusion (I/R) in rats, the lungs being the remote organ system. Methods : Thirty-five male Wistar rats were assigned to one of five conditions (n = 7/group), as follows: sham operation (control group); hind-limb ischemia, induced by clamping the left femoral artery, for 2 h, followed by 24 h of reperfusion (I/R group); and hind-limb ischemia, as above, followed by intraperitoneal injection (prior to reperfusion) of 150 mg/kg of NAC (I/R+NAC group), 40 mg/kg of pentoxifylline (I/R+PTX group), or both (I/R+NAC+PTX group). At the end of the trial, lung tissues were removed for histological analysis and assessment of oxidative stress. Results : In comparison with the rats in the other groups, those in the I/R group showed lower superoxide dismutase activity and glutathione levels, together with higher malondialdehyde levels and lung injury scores (p < 0.05 for all). Interstitial inflammatory cell infiltration of the lungs was also markedly greater in the I/R group than in the other groups. In addition, I/R group rats showed various signs of interstitial edema and hemorrhage. In the I/R+NAC, I/R+PTX, and I/R+NAC+PTX groups, superoxide dismutase activity, glutathione levels, malondialdehyde levels, and lung injury scores were preserved (p < 0.05 for all). The differences between the administration of NAC or pentoxifylline alone and the administration of the two together were not significant for any of those parameters (p > 0.05 for all). Conclusions : Our results suggest that NAC and pentoxifylline both protect lung tissue from the effects of skeletal muscle I/R. However, their combined use does not appear to increase the level of that protection.

scholarly journals Melatonin attenuates lung injury in a hind limb ischemia–reperfusion rat model

2015 ◽  
Vol 21 (1) ◽  
pp. 30-35 ◽  
Author(s):  
Hamed Takhtfooladi ◽  
Mohammad Takhtfooladi ◽  
Fariborz Moayer ◽  
Sayed Mobarakeh
Keyword(s):  
Lung Injury ◽  
Rat Model ◽  
Hind Limb ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Hind Limb Ischemia

scholarly journals Role of Scutellarin in Ameliorating Lung Injury in a Rat Model of Bilateral Hind Limb Ischemia–Reperfusion

2019 ◽  
Vol 302 (11) ◽  
pp. 2070-2081 ◽  
Author(s):  
Marwa A. A. Ibrahim ◽  
Walaa M. Elwan ◽  
Hanan A. Elgendy
Keyword(s):  
Lung Injury ◽  
Rat Model ◽  
Hind Limb ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Hind Limb Ischemia

Dysregulated Renin-AngioteNsin System Contributes to acute Lung Injury Caused by Hind-limb Ischemia-Reperfusion in Mice

Shock ◽  
2013 ◽  
Vol 40 (5) ◽  
pp. 420-429 ◽  
Author(s):  
Li-Nan Chen ◽  
Xiu-Hong Yang ◽  
Daniel H. Nissen ◽  
Yan-Yan Chen ◽  
Li-Jun Wang ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Hind Limb ◽  
Ischemia Reperfusion ◽  
Renin Angiotensin System ◽  
Limb Ischemia ◽  
Angiotensin System ◽  
Hind Limb Ischemia ◽  
Renin Angiotensin

The influence of iloprost on acute lung injury induced by hind limb ischemia-reperfusion in rats

2005 ◽  
Vol 18 (4) ◽  
pp. 235-241 ◽  
Author(s):  
Oguz Koksel ◽  
Ali Ozdulger ◽  
Barlas Aytacoglu ◽  
Lulufer Tamer ◽  
Ayse Polat ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Hind Limb ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Hind Limb Ischemia

scholarly journals Apolipoprotein E–/– mice have delayed skeletal muscle healing after hind limb ischemia–reperfusion

2008 ◽  
Vol 48 (3) ◽  
pp. 701-708 ◽  
Author(s):  
Jeanwan Kang ◽  
Hassan Albadawi ◽  
Virendra I. Patel ◽  
Thomas A. Abbruzzese ◽  
Jin-Hyung Yoo ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Apolipoprotein E ◽  
Hind Limb ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Hind Limb Ischemia
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