Determination of reference intervals for serum creatinine, creatinine excretion and creatinine clearance with an enzymatic and a modified Jaffé method

2004 ◽  
Vol 344 (1-2) ◽  
pp. 137-148 ◽  
Author(s):  
Wolfgang Junge ◽  
Baerbel Wilke ◽  
Atef Halabi ◽  
Gerhard Klein
Keyword(s):  
Serum Creatinine ◽  
Creatinine Clearance ◽  
Reference Intervals ◽  
Creatinine Excretion

Estimation of Renal Creatinine Clearance in Patients with Unstable Serum Creatinine Concentrations: Comparison of Multiple Methods

1985 ◽  
Vol 19 (5) ◽  
pp. 385-390 ◽  
Author(s):  
Moses Sing Sum Chow ◽  
Robert Schweizer
Keyword(s):  
Serum Creatinine ◽  
Creatinine Clearance ◽  
Simulated Data ◽  
Serum Creatinine Concentration ◽  
Creatinine Concentration ◽  
Creatinine Excretion ◽  
Urinary Creatinine ◽  
Transplant Patients ◽  
Urinary Creatinine Excretion

The accuracy of different methods of calculating 24-hour creatinine clearance in patients with unstable renal function was compared using simulated data (based on a one-compartment pharmacokinetic model), as well as data from postrenal transplant patients. When creatinine clearance was calculated from the urinary creatinine excretion and a serum creatinine concentration, the use of the midpoint serum creatinine concentration produced the lowest degree of error. Therefore, this method is recommended for routine clinical determination of creatinine clearance in such patients. When the urinary creatinine excretion was unknown, an iteration method produced the lowest degree of error among four methods, and therefore is recommended to estimate creatinine clearance in such patients.

scholarly journals Effects of moderate-dose versus high-dose trimethoprim on serum creatinine and creatinine clearance and adverse reactions.

1997 ◽  
Vol 41 (11) ◽  
pp. 2466-2470 ◽  
Author(s):  
O Naderer ◽  
A N Nafziger ◽  
J S Bertino
Keyword(s):  
Serum Creatinine ◽  
Creatinine Clearance ◽  
Dose Group ◽  
Serum Folate ◽  
High Dose ◽  
Drug Reactions ◽  
Moderate Dose ◽  
Creatinine Excretion ◽  
Urinary Creatinine ◽  
Urinary Creatinine Excretion

The effects of a 10-day course of moderate-dose (10 mg/kg/day) or high-dose (20 mg/kg/day) trimethoprim therapy on serum creatinine, measured creatinine clearance, urinary creatinine excretion, and serum folate were studied in 20 healthy volunteers. Serum creatinine concentrations increased significantly during trimethoprim therapy, began to decrease near day 10, and returned to baseline during the washout phase at both dosage levels. At the same time, measured creatinine clearance and urine creatinine changed in the opposite direction. No clinical or statistical differences were noted between changes in the moderate- versus the high-dose phases. Serum folate concentration decreases during high-dose trimethoprim therapy were statistically significant. Adverse drug reactions in the two groups were statistically different during the first study period, with the high-dose group having a 75% incidence rate and the moderate-dose group having an 11% incidence rate (P < 0.02). Serum creatinine, measured creatinine clearance, and urinary creatinine excretion demonstrated statistically, but not clinically, significant changes during trimethoprim therapy. In addition, high-dose trimethoprim caused significantly more adverse drug reactions than moderate-dose trimethoprim in normal volunteers.

Reference Values of Serum and Urine Creatinine, and of Creatinine Clearance by a New Enzymatic Method

1992 ◽  
Vol 29 (5) ◽  
pp. 523-528 ◽  
Author(s):  
O Sugita ◽  
K Uchiyama ◽  
T Yamada ◽  
T Sato ◽  
M Okada ◽  
...  
Keyword(s):  
Creatinine Clearance ◽  
Reference Intervals ◽  
Japanese Children ◽  
Mean Values ◽  
Urine Creatinine ◽  
Coefficients Of Variation ◽  
Analytical Recovery ◽  
Enzymatic Procedure ◽  
Serum And Urine

A new, totally enzymatic procedure for the determination of creatinine in serum and urine, using creatinine amidohydrolase, creatine amidinohydrolase, sarcosine oxidase and formaldehyde dehydrogenase is described. The assay was adapted to a discontinuous analyser with each analysis requiring only 20 μL of serum or 3 μL of urine. Analytical recovery of creatinine in serum and urine averaged 100·6%. Within-run and between-run precision studies gave coefficients of variation of 1·1% and 1·8%, respectively, for a serum with mean values of 83 μmol/L (9·4 mg/L) creatinine. Creatinine concentrations in serum and urine were measured by this procedure, in Japanese children and adults. The reference intervals for serum creatinine concentrations in adults were 55–96 μmol/L (6·2–10·9 mg/L) in men and 40–66 μmol/L (4·5–7·5 mg/L) in women, and for urine, 9·46–19·01 mmol/day (1070–2150 mg/day) in men and 6·75–10·61 mmol/day (764–1200 mg/day) in women. The reference intervals of creatinine clearance were 88·0–176·4 mL/min in men and 75·7–173·0 mL/min in women.

A useful method for predicting creatinine clearance in children.

1978 ◽  
Vol 24 (7) ◽  
pp. 1167-1169 ◽  
Author(s):  
B C Shull ◽  
D Haughey ◽  
J R Koup ◽  
T Baliah ◽  
P K Li
Keyword(s):  
Renal Function ◽  
Serum Creatinine ◽  
Creatinine Clearance ◽  
Pediatric Patients ◽  
Excretion Rate ◽  
Practical Method ◽  
Serum Creatinine Concentration ◽  
Creatinine Concentration ◽  
Creatinine Excretion ◽  
Creatinine Excretion Rate

Abstract A practical method for predicting creatinine clearance for pediatric patients from serum creatinine concentration and patient age is presented. Creatinine excretion rate (ER) can be predicted from the patient's age, in years, by the formula: ER = (0.035 X age) + 0.236. Using the predicted excretion rate and serum creatinine concentration, creatinine clearance can be predicted. There was good correlation (r = 0.90) between predicted and observed creatinine clearances in 101 subjects with various degrees of renal impairment. This method allows renal function to be rapidly estimated.

Estimation of Total Daily Creatinine Clearance in Capd from Serum Creatinine Concentration

1997 ◽  
Vol 17 (3) ◽  
pp. 250-254 ◽  
Author(s):  
Colin H. Jones ◽  
Charles G. Newstead ◽  
Eric J. Will
Keyword(s):  
Serum Creatinine ◽  
Creatinine Clearance ◽  
University Hospital ◽  
Dialysis Dose ◽  
Creatinine Concentration ◽  
Predictive Values ◽  
Creatinine Excretion ◽  
Clearance Studies ◽  
Group A ◽  
Males And Females

Objective To establish whether estimation of creatinine clearance (CrCI) from serum creatinine, gender, age, and weight might reduce the number of 24-hour urine and dialysate collections required to monitor adequacy of delivered dialysis on continuous ambulatory peritoneal dialysis (CAPO). Design Retrospective single-center study. Setting University Hospital. Patients Creatinine excretion and CrCI were measured in 187 24-hour urine and dialysate collections from 99 CAPO patients (55 male, 44 female). Multiple regression analysis was used to estimate creatinine excretion from age and weight in males and females. CrCI was derived and also calculated using the Cockcroft-Gault and Mitch-Walser formulas. Positive and negative predictive values for indicating adequacy of dialysis were determined. Results Measured and derived CrCI were correlated (males: r = 0.85; females: r = 0.83; p < 0.001), but agreement was poor (95% limits of agreement: males, 26.05 to -25.75 L/wk; females, 37.47 to -19.49 L/wk). Taking the minimum acceptable CrCI as 60 L/week, the respective positive predictive values of the derived, Cockcroft, and Mitch methods in predicting underdialysis were 88%, 100%, and 100% in males and 88%, 88%, and 89% in females. Negative predictive values were 83%, 57%, and 53% in males and 53%, 48%, and 45% in females. Conclusion A derived CrCI >6 0 was not predictive of adequate dialysis. Because the detection of underdialysis is our objective, formal clearance studies should be performed in this group. A derived CrCI <60 L/wk was predictive of underdialysis in males and females and an increase in dialysis dose without formal clearance measurements could be suggested in these patients. The use of this approach could allow an important reduction in the number of clearance studies required to monitor CAPO adequacy.

scholarly journals Adult Reference Ranges for Serum Cystatin C, Creatinine and Predicted Creatinine Clearance

2000 ◽  
Vol 37 (1) ◽  
pp. 49-59
Author(s):  
Hazel Finney ◽  
David J Newman ◽  
Christopher P Price
Keyword(s):  
Serum Creatinine ◽  
Creatinine Clearance ◽  
Cystatin C ◽  
Blood Donors ◽  
Reference Range ◽  
Reference Interval ◽  
Reference Intervals ◽  
Reference Ranges ◽  
Serum Cystatin C ◽  
Serum Cystatin

Serum cystatin C measurement has been previously shown by ourselves and others to be a better indicator of changes in glomerular filtration rate (GFR) than serum creatinine. However, the available literature on reference values for cystatin C concentration remains surprisingly sparse; we thus set out to determine an adult reference range. Blood was taken from 309 healthy blood donors and creatinine and cystatin C concentrations were measured using commercially available automated methodologies. In addition, predicted creatinine clearances were calculated using the Cockcroft and Gault formula. The 95% reference intervals for creatinine, predicted creatinine clearance and cystatin C for all blood donors, regardless of gender, were 68–118 μmol/L, 58–120 ml/min/1·73 m2 and 0·51–0·98 mg/L, respectively. For women, the intervals were 68–98 μmol/L, 60–119 ml/min/1·73 m2 and 0·49–0·94 mg/L; for men, they were 78–123 μmol/L, 57–122 ml/min/1·73 m2 and 0·56–0·98 mg/L. The mean 95% reference interval for cystatin C in all donors under 50 years of age was 0·53–0·92 mg/L; for those over 50 years of age it was 0·58–1·02 mg/L. The small difference between male and female ranges meant that a single reference range for cystatin C could be established for all adults under 50 years of age without adjustment for body surface area. Serum cystatin C measurement offers a simpler and more sensitive screening test than serum creatinine for early changes in GFR.

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