Estimation of Renal Creatinine Clearance in Patients with Unstable Serum Creatinine Concentrations: Comparison of Multiple Methods

The accuracy of different methods of calculating 24-hour creatinine clearance in patients with unstable renal function was compared using simulated data (based on a one-compartment pharmacokinetic model), as well as data from postrenal transplant patients. When creatinine clearance was calculated from the urinary creatinine excretion and a serum creatinine concentration, the use of the midpoint serum creatinine concentration produced the lowest degree of error. Therefore, this method is recommended for routine clinical determination of creatinine clearance in such patients. When the urinary creatinine excretion was unknown, an iteration method produced the lowest degree of error among four methods, and therefore is recommended to estimate creatinine clearance in such patients.

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Serum creatinine concentration, urinary creatinine excretion and creatinine clearance during the first 9 weeks in preterm infants with a birth weight below 1500 g

European Journal of Pediatrics ◽

10.1007/bf02002914 ◽

1996 ◽

Vol 155 (9) ◽

pp. 815-819 ◽

Cited By ~ 81

Author(s):

J. Sonntag ◽

B. Prankel ◽

S. Waltz

Keyword(s):

Birth Weight ◽

Serum Creatinine ◽

Creatinine Clearance ◽

Preterm Infants ◽

Serum Creatinine Concentration ◽

Creatinine Concentration ◽

Creatinine Excretion ◽

Urinary Creatinine ◽

Urinary Creatinine Excretion

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Serum creatinine concentration, urinary creatinine excretion and creatinine clearance during the first 9 weeks in preterm infants with a birth weight below 1500 g

European Journal of Pediatrics ◽

10.1007/s004310050494 ◽

1996 ◽

Vol 155 (9) ◽

pp. 815-819 ◽

Cited By ~ 1

Author(s):

J. Sonntag ◽

B. Prankel ◽

S. Waltz

Keyword(s):

Birth Weight ◽

Serum Creatinine ◽

Creatinine Clearance ◽

Preterm Infants ◽

Serum Creatinine Concentration ◽

Creatinine Concentration ◽

Creatinine Excretion ◽

Urinary Creatinine ◽

Urinary Creatinine Excretion

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Effects of moderate-dose versus high-dose trimethoprim on serum creatinine and creatinine clearance and adverse reactions.

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.41.11.2466 ◽

1997 ◽

Vol 41 (11) ◽

pp. 2466-2470 ◽

Cited By ~ 40

Author(s):

O Naderer ◽

A N Nafziger ◽

J S Bertino

Keyword(s):

Serum Creatinine ◽

Creatinine Clearance ◽

Dose Group ◽

Serum Folate ◽

High Dose ◽

Drug Reactions ◽

Moderate Dose ◽

Creatinine Excretion ◽

Urinary Creatinine ◽

Urinary Creatinine Excretion

The effects of a 10-day course of moderate-dose (10 mg/kg/day) or high-dose (20 mg/kg/day) trimethoprim therapy on serum creatinine, measured creatinine clearance, urinary creatinine excretion, and serum folate were studied in 20 healthy volunteers. Serum creatinine concentrations increased significantly during trimethoprim therapy, began to decrease near day 10, and returned to baseline during the washout phase at both dosage levels. At the same time, measured creatinine clearance and urine creatinine changed in the opposite direction. No clinical or statistical differences were noted between changes in the moderate- versus the high-dose phases. Serum folate concentration decreases during high-dose trimethoprim therapy were statistically significant. Adverse drug reactions in the two groups were statistically different during the first study period, with the high-dose group having a 75% incidence rate and the moderate-dose group having an 11% incidence rate (P < 0.02). Serum creatinine, measured creatinine clearance, and urinary creatinine excretion demonstrated statistically, but not clinically, significant changes during trimethoprim therapy. In addition, high-dose trimethoprim caused significantly more adverse drug reactions than moderate-dose trimethoprim in normal volunteers.

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A useful method for predicting creatinine clearance in children.

Clinical Chemistry ◽

10.1093/clinchem/24.7.1167 ◽

1978 ◽

Vol 24 (7) ◽

pp. 1167-1169 ◽

Cited By ~ 25

Author(s):

B C Shull ◽

D Haughey ◽

J R Koup ◽

T Baliah ◽

P K Li

Keyword(s):

Renal Function ◽

Serum Creatinine ◽

Creatinine Clearance ◽

Pediatric Patients ◽

Excretion Rate ◽

Practical Method ◽

Serum Creatinine Concentration ◽

Creatinine Concentration ◽

Creatinine Excretion ◽

Creatinine Excretion Rate

Abstract A practical method for predicting creatinine clearance for pediatric patients from serum creatinine concentration and patient age is presented. Creatinine excretion rate (ER) can be predicted from the patient's age, in years, by the formula: ER = (0.035 X age) + 0.236. Using the predicted excretion rate and serum creatinine concentration, creatinine clearance can be predicted. There was good correlation (r = 0.90) between predicted and observed creatinine clearances in 101 subjects with various degrees of renal impairment. This method allows renal function to be rapidly estimated.

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