scholarly journals Effects of moderate-dose versus high-dose trimethoprim on serum creatinine and creatinine clearance and adverse reactions.

1997 ◽  
Vol 41 (11) ◽  
pp. 2466-2470 ◽  
Author(s):  
O Naderer ◽  
A N Nafziger ◽  
J S Bertino
Keyword(s):  
Serum Creatinine ◽  
Creatinine Clearance ◽  
Dose Group ◽  
Serum Folate ◽  
High Dose ◽  
Drug Reactions ◽  
Moderate Dose ◽  
Creatinine Excretion ◽  
Urinary Creatinine ◽  
Urinary Creatinine Excretion

The effects of a 10-day course of moderate-dose (10 mg/kg/day) or high-dose (20 mg/kg/day) trimethoprim therapy on serum creatinine, measured creatinine clearance, urinary creatinine excretion, and serum folate were studied in 20 healthy volunteers. Serum creatinine concentrations increased significantly during trimethoprim therapy, began to decrease near day 10, and returned to baseline during the washout phase at both dosage levels. At the same time, measured creatinine clearance and urine creatinine changed in the opposite direction. No clinical or statistical differences were noted between changes in the moderate- versus the high-dose phases. Serum folate concentration decreases during high-dose trimethoprim therapy were statistically significant. Adverse drug reactions in the two groups were statistically different during the first study period, with the high-dose group having a 75% incidence rate and the moderate-dose group having an 11% incidence rate (P < 0.02). Serum creatinine, measured creatinine clearance, and urinary creatinine excretion demonstrated statistically, but not clinically, significant changes during trimethoprim therapy. In addition, high-dose trimethoprim caused significantly more adverse drug reactions than moderate-dose trimethoprim in normal volunteers.

Estimation of Renal Creatinine Clearance in Patients with Unstable Serum Creatinine Concentrations: Comparison of Multiple Methods

1985 ◽  
Vol 19 (5) ◽  
pp. 385-390 ◽  
Author(s):  
Moses Sing Sum Chow ◽  
Robert Schweizer
Keyword(s):  
Serum Creatinine ◽  
Creatinine Clearance ◽  
Simulated Data ◽  
Serum Creatinine Concentration ◽  
Creatinine Concentration ◽  
Creatinine Excretion ◽  
Urinary Creatinine ◽  
Transplant Patients ◽  
Urinary Creatinine Excretion

The accuracy of different methods of calculating 24-hour creatinine clearance in patients with unstable renal function was compared using simulated data (based on a one-compartment pharmacokinetic model), as well as data from postrenal transplant patients. When creatinine clearance was calculated from the urinary creatinine excretion and a serum creatinine concentration, the use of the midpoint serum creatinine concentration produced the lowest degree of error. Therefore, this method is recommended for routine clinical determination of creatinine clearance in such patients. When the urinary creatinine excretion was unknown, an iteration method produced the lowest degree of error among four methods, and therefore is recommended to estimate creatinine clearance in such patients.

MO190NORMATIVE DATA FOR GLOMERULAR FILTRATION RATE IN HEALTHY KIDNEY DONOR POPULATION

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Ashish Bhoyar ◽  
Vinant Bhargava ◽  
Ashwani Gupta ◽  
Anurag Gupta ◽  
Vaibhav Tiwari ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Serum Creatinine ◽  
Creatinine Clearance ◽  
Filtration Rate ◽  
Age Groups ◽  
Kidney Donor ◽  
Urinary Creatinine ◽  
Donor Population ◽  
Sample Method ◽  
Clearance Methods

Abstract Background and Aims Glomerular filtration rate (GFR) is estimated traditionally from 24-hour urinary creatinine clearance. Creatinine is mainly filtered by glomerulus. The collection of 24-hour urinary sample is a difficult task with many patients fail to collect all the urine samples. As measuring GFR is cumbersome, expensive, and not easily available in all centers, various equations are developed for estimating GFR from creatinine like MDRD, CKD EPI creatinine. GFR obtained from serum creatinine shows wide variation as muscle mass and dietary protein intake are important determinants of serum creatinine concentration. Literature shows very few studies with GFR estimation with reference to age in Indian population. Hence, this study is planned to develop age specific nomogram for GFR in healthy kidney donor population as well as to study agreement between GFR obtained by 99m Tc DTPA three sample method and GFR estimated by 24-hour urinary creatinine. The aim of this stidy was to develop age-specific nomogram GFR in healthy kidney donor population and to study the agreement between the GFR measured by Technetium-99m diethylene triamine pentaacetic acid (99m Tc DTPA) and 24-hour urinary creatinine method. Method This study was conducted at Sir Ganga Ram hospital, New Delhi. All healthy individuals aged more than 20 years and less than 65 years, undergoing evaluation as prospective kidney donor at our hospital were the part of this study. GFR was measured by 99m Tc DTPA clearance using 3 sample method. GFR measured by DTPA method was used to develop nomogram. Creatinine Clearance was calculated from 24-hour urinary creatinine by formula U x V/P where, U is urinary creatinine level, P is plasma creatinine level and V is total volume of urine. Nomogram was developed with respect to these 3 Age groups; namely, 20 to 40 years, 40 to 50 years and 50 to 65 years Results Total 100 kidney donors were included in this study. Enrolled subjects were divided into 3 age groups; 20 to 40 years (n=28), 40 to 50 years (n=46) and 50 to 65 years (n=26). Majority of the donors were females (n=80). The agreement between GFR obtained by 99m Tc DTPA and 24-hour urinary creatinine clearance methods was 92.6 vs. 94 ml/min, 80.4 vs. 76 ml/min and 76.3 vs. 70 ml/min in respective age groups. Conclusion In the younger age group (20 to 40 years), there is better agreement in GFR measured by 99m Tc DTPA method and 24-hour urinary creatinine clearance methods.

Creatinine Excretion

PEDIATRICS ◽  
1983 ◽  
Vol 71 (1) ◽  
pp. 140-140
Author(s):  
JAMES L. SUTPHEN
Keyword(s):  
Muscle Mass ◽  
Initial Presentation ◽  
Creatinine Excretion ◽  
Urinary Creatinine ◽  
Weight Measurement ◽  
Body Muscle ◽  
Creatinine Measurement ◽  
Urinary Creatinine Excretion

In Reply.— The questions posed by Harkavy allow me to expand on the initial presentation of the data in my previous report.1 As documented by numerous previous reports, urinary creatinine excretion does, in fact, reflect body muscle mass.2 Furthermore, it has been documented in older infants that creatinine excretion per kilogram increases with the age, weight, and length of the infant.3 The regression data in my report are not expressed in terms of creatinine per kilogram as the dependent variable as this multiplies the error of creatinine measurement by including the error in weight measurement (hydration states etc).

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