Synthesis and in vitro biological evaluation of nitric oxide-releasing derivatives of hydroxylcinnamic acids as anti-tumor agents

2013 ◽  
Vol 24 (5) ◽  
pp. 415-418 ◽  
Author(s):  
Ming-Dong Lu ◽  
Xiao Zhou ◽  
Yao-Jun Yu ◽  
Pi-Hong Li ◽  
Wei-Jian Sun ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Biological Evaluation ◽  
Nitric Oxide Releasing ◽  
Derivatives Of

Nitric Oxide-Donating Derivatives of Chrysin Stimulate Angiogenesis and Upregulating VEGF Production

2011 ◽  
Vol 340 ◽  
pp. 363-368 ◽  
Author(s):  
Xiao Qing Zou ◽  
Yong Lan Ding ◽  
Sheng Ming Peng ◽  
Chang Ping Hu ◽  
Han Wu Deng ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Therapeutic Option ◽  
Therapeutic Angiogenesis ◽  
Vegf Mrna ◽  
No Donor ◽  
Endothelial Migration ◽  
Nitric Oxide Releasing ◽  
Derivatives Of

Angiogenesis, the development of new capillaries from pre-existing vessels, requires the coordinate activation of endothelial cells, which migrate and proliferate to form functional vessels. Endothelial dysfunction and decreased nitric oxide bioavailability may underscore the impairment of angiogenesis. As such, the delivery of exogenous NO is an attractive therapeutic option that has been used to therapeutic angiogenesis. In this paper, a novel group of hybrid nitric oxide-releasing chrysin derivatives was synthesized. The results indicated that all these chrysin derivatives exhibited promotion of endothelial migration and tubulogenesis in vitro as well as stimulation angiogenesis in vivo.Furthermore, all compounds released NO upon incubation with phosphate buffer at pH 7.4 and enhanced VEGF secretion and VEGF mRNA expression of endothelial cells. These hybrid ester NO donor prodrugs offer a potential drug design concept for the development of therapeutic or preventive agents for angiogenesis deficiency due to ischemic diseases.

Synthesis and Biological Evaluation of Nitric Oxide-releasing Derivatives of Capsaicin as Analgesia Drugs

2011 ◽  
Vol 8 (1) ◽  
pp. 76-81 ◽  
Author(s):  
Liang Ge ◽  
jingjie Wang ◽  
Xiaoyan Zhang ◽  
Huibin Zhang ◽  
Hai Qian ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Biological Evaluation ◽  
Nitric Oxide Releasing ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

Synthesis and biological evaluation of nitric oxide-releasing hybrids from gemcitabine and phenylsulfonyl furoxans as anti-tumor agents

MedChemComm ◽  
2015 ◽  
Vol 6 (6) ◽  
pp. 1130-1136 ◽  
Author(s):  
Xianghua Li ◽  
Xuemin Wang ◽  
Chenjun Xu ◽  
Junkai Huang ◽  
Chengniu Wang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Tumor Cells ◽  
Biological Evaluation ◽  
Nucleoside Transporter ◽  
Antitumor Activities ◽  
Induce Cell Apoptosis ◽  
Nitric Oxide Releasing ◽  
Related Proteins ◽  
Synthesis And Biological Evaluation

Novel furoxan/gemcitabine hybrids displayed significant antitumor activities, in particular 10e, which could be independent of the nucleoside transporter, release high levels of NO, and induce cell apoptosis by regulating apoptotic related proteins in tumor cells in vitro.

Identification of nitric oxide-releasing derivatives of oleanolic acid as potential anti-colon cancer agents

RSC Advances ◽  
2015 ◽  
Vol 5 (25) ◽  
pp. 19445-19454 ◽  
Author(s):  
Junjie Fu ◽  
Yu Zou ◽  
Zhangjian Huang ◽  
Chang Yan ◽  
Qimeng Zhou ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Colon Cancer ◽  
Signaling Pathways ◽  
Oleanolic Acid ◽  
Nitric Oxide Releasing ◽  
Derivatives Of ◽  
Cancer Activity

NO-releasing hybrid 6 regulates colon cancer-related signaling pathways, exhibiting potent anti-colon cancer activity in vitro and in vivo.

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