Highly Efficient Approach to the Total Synthesis of Flavoxate Hydrochloride

2021 ◽  
pp. 100694
Author(s):  
Kalidasu Sheelam ◽  
Sridhar Chidara ◽  
Srilalitha Vinnakota ◽  
Ravikumar Polothi
Keyword(s):  
Total Synthesis ◽  
Efficient Approach ◽  
Highly Efficient ◽  
Flavoxate Hydrochloride

scholarly journals Stereocontrolled total synthesis of (+)-vinblastine

2003 ◽  
Vol 75 (1) ◽  
pp. 29-38 ◽  
Author(s):  
Satoshi Yokoshima ◽  
T. Ueda ◽  
S. Kobayashi ◽  
A. Sato ◽  
Takeshi Kuboyama ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Coupling Reaction ◽  
Radical Cyclization ◽  
Critical Coupling ◽  
Efficient Manner ◽  
Complete Control ◽  
Highly Efficient ◽  
Indole Synthesis

Stereocontrolled total synthesis of (+)-vinblastine (1) has been achieved using a novel radical-mediated indole synthesis developed in our laboratories. The isothiocyanate 18, prepared readily from quinoline 17, underwent a facile addition of the malonate anion to give 19. The o-alkenylthioanilide 19 was then converted to indole 20 by radical cyclization and protection. (−)-Vindoline (2) was prepared from this key intermediate 20 in a highly efficient manner. The indole core of the 11-membered intermediate 3 was constructed similarly from quinoline. The critical coupling reaction between 2 and the chloroindolenine derived from 3 proceeded with complete control of stereochemistry to give the desired product 66 in 97 % yield, which could be successfully converted to (+)-vinblastine (1).

ChemInform Abstract: A HIGHLY EFFICIENT TOTAL SYNTHESIS OF (.+-.)-LYCOPODINE

1979 ◽  
Vol 10 (12) ◽  
Author(s):  
C. H. HEATHCOCK ◽  
E. KLEINMAN ◽  
E. S. BINKLEY
Keyword(s):  
Total Synthesis ◽  
Highly Efficient

Organocatalytic Asymmetric Direct C sp 3H Functionalization of Ethers: A Highly Efficient Approach to Chiral Spiroethers

2012 ◽  
Vol 124 (35) ◽  
pp. 8941-8945 ◽  
Author(s):  
Zhi-Wei Jiao ◽  
Shu-Yu Zhang ◽  
Chuan He ◽  
Yong-Qiang Tu ◽  
Shao-Hua Wang ◽  
...  
Keyword(s):  
Efficient Approach ◽  
Highly Efficient

ChemInform Abstract: An Organocatalytic Highly Efficient Approach to the Direct Synthesis of Substituted Carbazoles in Water.

ChemInform ◽  
2014 ◽  
Vol 45 (14) ◽  
pp. no-no
Author(s):  
Pradeep Kumar Jaiswal ◽  
Soumen Biswas ◽  
Shivendra Singh ◽  
Sampak Samanta
Keyword(s):  
Direct Synthesis ◽  
Efficient Approach ◽  
Highly Efficient
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