An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors

Chemistry & Biology ◽

10.1016/j.chembiol.2015.06.018 ◽

2015 ◽

Vol 22 (8) ◽

pp. 1063-1073 ◽

Author(s):

Christopher B. Marotta ◽

Henry A. Lester ◽

Dennis A. Dougherty

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Nicotinic Acetylcholine ◽

Allosteric Interactions ◽

Α7 Nicotinic Acetylcholine Receptors

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Modeling Subtype-Selective Agonists Binding with α4β2 and α7 Nicotinic Acetylcholine Receptors: Effects of Local Binding and Long-Range Electrostatic Interactions

Journal of Medicinal Chemistry ◽

10.1021/jm0606701 ◽

2006 ◽

Vol 49 (26) ◽

pp. 7661-7674 ◽

Author(s):

Xiaoqin Huang ◽

Fang Zheng ◽

Xi Chen ◽

Peter A. Crooks ◽

Linda P. Dwoskin ◽

...

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Electrostatic Interactions ◽

Nicotinic Acetylcholine ◽

Α7 Nicotinic Acetylcholine Receptors ◽

Selective Agonists ◽

Subtype Selective ◽

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Engineered Conotoxin Differentially Blocks and Discriminates Rat and Human α7 Nicotinic Acetylcholine Receptors

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c02079 ◽

2021 ◽

Author(s):

Shuai Wang ◽

Xiaopeng Zhu ◽

Manqi Zhangsun ◽

Yong Wu ◽

Jinpeng Yu ◽

...

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Nicotinic Acetylcholine ◽

Α7 Nicotinic Acetylcholine Receptors

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GTS-21 has cell-specific anti-inflammatory effects independent of α7 nicotinic acetylcholine receptors

PLoS ONE ◽

10.1371/journal.pone.0214942 ◽

2019 ◽

Vol 14 (4) ◽

pp. e0214942 ◽

Author(s):

Brijesh K. Garg ◽

Ralph H. Loring

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Nicotinic Acetylcholine ◽

Α7 Nicotinic Acetylcholine Receptors ◽

Anti Inflammatory

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Explore the role of lymphocyte antigen 6/urokinase-type plasminogen activator receptor related protein-1 in melanoma promoting caused by signaling of α7-nicotinic acetylcholine receptors

Journal of the Neurological Sciences ◽

10.1016/j.jns.2017.08.3497 ◽

2017 ◽

Vol 381 ◽

pp. 456-457

Author(s):

P.J. Lin ◽

S.H. Jee ◽

C.Y. Chang

Keyword(s):

Plasminogen Activator ◽

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Related Protein ◽

Nicotinic Acetylcholine ◽

Type Plasminogen Activator ◽

Urokinase Type Plasminogen Activator ◽

Α7 Nicotinic Acetylcholine Receptors ◽

Plasminogen Activator Receptor

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Inhibition of human α7 nicotinic acetylcholine receptors by open channel blockers of N -methyl-D -aspartate receptors

British Journal of Pharmacology ◽

10.1038/sj.bjp.0705559 ◽

2003 ◽

Vol 140 (7) ◽

pp. 1313-1319 ◽

Author(s):

Peter D Maskell ◽

Pauline Speder ◽

Nigel R Newberry ◽

Isabel Bermudez

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Open Channel ◽

Channel Blockers ◽

Nicotinic Acetylcholine ◽

Α7 Nicotinic Acetylcholine Receptors

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Role of α7 nicotinic acetylcholine receptors in the synaptic transmission at the frog neuromuscular contacts

Bulletin of Experimental Biology and Medicine ◽

10.47056/0365-9615-2021-172-11-564-569 ◽

2021 ◽

Vol 172 (11) ◽

pp. 564-569

Author(s):

O. A. Lenina ◽

◽

I. V. Kovyazina ◽

Keyword(s):

Synaptic Transmission ◽

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Nicotinic Acetylcholine ◽

Α7 Nicotinic Acetylcholine Receptors

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Neonicotinoid insecticides differently modulate acetycholine-induced currents on mammalian α7 nicotinic acetylcholine receptors

British Journal of Pharmacology ◽

10.1111/bph.14018 ◽

2017 ◽

Vol 175 (11) ◽

pp. 1987-1998 ◽

Author(s):

Alison Cartereau ◽

Carine Martin ◽

Steeve H Thany

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Nicotinic Acetylcholine ◽

Neonicotinoid Insecticides ◽

Α7 Nicotinic Acetylcholine Receptors ◽

Induced Currents

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Cigarette toxin 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces experimental pancreatitis through α7 nicotinic acetylcholine receptors (nAChRs) in mice

PLoS ONE ◽

10.1371/journal.pone.0197362 ◽

2018 ◽

Vol 13 (6) ◽

pp. e0197362 ◽

Author(s):

A. A. Alahmari ◽

B. Sreekumar ◽

V. Patel ◽

M. Ashat ◽

M. Alexandre ◽

...

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Experimental Pancreatitis ◽

Nicotinic Acetylcholine ◽

Α7 Nicotinic Acetylcholine Receptors

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Macroscopic and Microscopic Activation of α7 Nicotinic Acetylcholine Receptors by the Structurally Unrelated Allosteric Agonist-Positive Allosteric Modulators (ago-PAMs) B-973B and GAT107

Molecular Pharmacology ◽

10.1124/mol.118.113340 ◽

2018 ◽

Vol 95 (1) ◽

pp. 43-61 ◽

Author(s):

Marta Quadri ◽

Sumanta Garai ◽

Ganesh A. Thakur ◽

Clare Stokes ◽

Alican Gulsevin ◽

...

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulators ◽

Nicotinic Acetylcholine ◽

Α7 Nicotinic Acetylcholine Receptors ◽

Positive Allosteric Modulators

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P2-296: α7 nicotinic acetylcholine receptors contribute to amyloid-induced neuronal hyperexcitation

Alzheimer s & Dementia ◽

10.1016/j.jalz.2010.05.1346 ◽

2010 ◽

Vol 6 ◽

pp. S400-S400 ◽

Author(s):

Jie Wu ◽

Qiang Liu ◽

Paul Whiteaker ◽

Ronald J. Lukas

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Nicotinic Acetylcholine ◽

Α7 Nicotinic Acetylcholine Receptors

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