Single and combined exposure of microcystin-LR and nitrite results in reproductive endocrine disruption via hypothalamic-pituitary-gonadal-liver axis

Chemosphere ◽  
2018 ◽  
Vol 211 ◽  
pp. 1137-1146 ◽  
Author(s):  
Wang Lin ◽  
Honghui Guo ◽  
Yufen Li ◽  
Lingkai Wang ◽  
Dandan Zhang ◽  
...  
Keyword(s):  
Endocrine Disruption ◽  
Combined Exposure ◽  
Reproductive Endocrine

scholarly journals Ecotoxicological Effect of Single and Combined Exposure of Carbamazepine and Cadmium on Female Danio rerio: A Multibiomarker Study

2019 ◽  
Vol 9 (7) ◽  
pp. 1362 ◽  
Author(s):  
Chunhong Shi ◽  
Yide He ◽  
Jiaxin Liu ◽  
Yue Lu ◽  
Yuting Fan ◽  
...  
Keyword(s):  
Endocrine Disruption ◽  
Danio Rerio ◽  
Antioxidant Systems ◽  
Aquatic Environments ◽  
Toxicity Profile ◽  
Combined Exposure ◽  
Single Exposure ◽  
Aquatic Vertebrates ◽  
Ecotoxicological Effect ◽  
Environmental Relevance

In aquatic environments, organisms are exposed to mixtures of pollutants which may change the toxicity profile of each contaminant, compared to its toxicity alone. Carbamazepine (CBZ) and cadmium (Cd) are among the pollutants that co-occur in aquatic environments. To date, most research about their toxicity towards aquatic vertebrates is based on single exposure experiments. The present study aims to evaluate single and combined effects of CBZ and Cd on biomarkers in female Danio rerio (zebrafish) by exposing them to environmentally relevant concentrations of these two pollutants for ten days. Four kinds of biomarkers involved in antioxidant systems, energy metabolism, nervous system, and endocrine disruption, respectively, were studied. Our research results coincided with those of former studies in single exposure experiments. However, the combined exposure of CBZ and Cd exerted different responses from other studies in which these two contaminants were examined alone in zebrafish. The present study evidenced the need to conduct more coexposure studies to enhance the environmental relevance of these experimental results.

5S rRNA and Accompanying Proteins in Gonads: Powerful Markers to Identify Sex and Reproductive Endocrine Disruption in Fish

2012 ◽  
Vol 46 (14) ◽  
pp. 7763-7771 ◽  
Author(s):  
Oihane Diaz de Cerio ◽  
Iratxe Rojo-Bartolomé ◽  
Cristina Bizarro ◽  
Maren Ortiz-Zarragoitia ◽  
Ibon Cancio
Keyword(s):  
Endocrine Disruption ◽  
5S Rrna ◽  
Reproductive Endocrine
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