Enantiomeric separation of volatile organics by gas chromatography for the in situ analysis of extraterrestrial materials: Kinetics and thermodynamics investigation of various chiral stationary phases

2013 ◽  
Vol 1306 ◽  
pp. 59-71 ◽  
Author(s):  
C. Freissinet ◽  
A. Buch ◽  
C. Szopa ◽  
R. Sternberg
Keyword(s):  
Gas Chromatography ◽  
Stationary Phases ◽  
Chiral Stationary Phases ◽  
Enantiomeric Separation ◽  
In Situ Analysis ◽  
Volatile Organics ◽  
Kinetics And Thermodynamics ◽  
Extraterrestrial Materials

Chiral separation and analysis of antifungal drugs by chromatographic and electromigration techniques: Results achieved in 2010–2020

2021 ◽  
Vol 40 (1) ◽  
pp. 220-252
Author(s):  
Giovanni D’Orazio ◽  
Chiara Fanali ◽  
Chiara Dal Bosco ◽  
Alessandra Gentili ◽  
Salvatore Fanali
Keyword(s):  
Gas Chromatography ◽  
Pharmaceutical Industry ◽  
State Of The Art ◽  
Stationary Phases ◽  
Enantiomeric Separation ◽  
Antifungal Drugs ◽  
Chiral Discrimination ◽  
Food Science ◽  
Industry Environment ◽  
Metabolic Activities

Abstract The determination and separation of enantiomers is an interesting and important topic of research in various fields, e.g., biochemistry, food science, pharmaceutical industry, environment, etc. Although these compounds possess identical physicochemical properties, a pair of enantiomers often has different pharmacological, toxicological, and metabolic activities. For this reason, chiral discrimination by using chromatographic and electromigration techniques has become an urgent need in the pharmaceutical field. This review intends to offer the “state of the art” about the separation of chiral antifungal drugs and several related precursors by both liquid and gas chromatography, as well as electromigration methods. This overview is organized into two sections. The first one describes general considerations on chiral antifungal drugs. The second part deals with the main analytical methods for the enantiomeric discrimination of these drugs, including a brief description of chiral selectors and stationary phases. Moreover, many recent applications attesting the great interest of analytical chemists in the field of enantiomeric separation are presented.

Comparison between cellulose and amylose tris(3,5-dimethylphenylcarbamate) chiral stationary phases for enantiomeric separation of 17 amidotetralins

Chirality ◽  
1993 ◽  
Vol 5 (7) ◽  
pp. 545-553 ◽  
Author(s):  
Dirk T. Witte ◽  
Frank J. Bruggeman ◽  
Jan Piet Franke ◽  
Swier Copinga ◽  
Johanna M. Jansen ◽  
...  
Keyword(s):  
Stationary Phases ◽  
Chiral Stationary Phases ◽  
Enantiomeric Separation
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