Thromboembolic Events during Endovascular Coiling for Unruptured Intracranial Aneurysms: Clinical Significance of Platelet Reactivity Unit and Adjunctive Cilostazol

2022 ◽  
pp. 107133
Author(s):  
Gung Ju Kim ◽  
Yeon Heo ◽  
Eun Ji Moon ◽  
Wonhyoung Park ◽  
Jae Sung Ahn ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Intracranial Aneurysms ◽  
Platelet Reactivity ◽  
Endovascular Coiling ◽  
Thromboembolic Events ◽  
Unruptured Intracranial Aneurysms

scholarly journals Complications of endovascular treatment for intracranial aneurysms: Management and prevention

2018 ◽  
Vol 24 (3) ◽  
pp. 237-245 ◽  
Author(s):  
Yon Kwon Ihn ◽  
Shang Hun Shin ◽  
Seung Kug Baik ◽  
In Sup Choi
Keyword(s):  
Endovascular Treatment ◽  
Intracranial Aneurysms ◽  
Clinical Results ◽  
Flow Diverter ◽  
Endovascular Coiling ◽  
Thromboembolic Events ◽  
Comprehensive Review ◽  
Complex Aneurysms ◽  
Novel Treatment ◽  
Satisfactory Outcome

Endovascular coiling for intracranial aneurysms has become an accepted treatment with good clinical results and provides adequate protection against rebleeding and rupture of aneurysms. However, despite the experience, preparation, or skill of the physician, complications during endovascular treatment still occur. The main complications of endovascular coiling are: procedural aneurysmal perforations by the microcatheter, micro-guidewire, or coil, and thromboembolic events. Such situations are unexpected, complex, and can have devastating consequences. In this article, we present a comprehensive review of the two most common complications, aneurysmal perforation and thromboembolism during endovascular coiling, and how we can prevent or overcome these complications to achieve a satisfactory outcome. In addition, as the flow diverter has been become an important tool for management of large, wide necked, and other anatomically challenging aneurysms, we also describe complications stemming from the use of the tool, which remains a novel treatment option for complex aneurysms.

Cognitive Outcome and Clinically Silent Thromboembolic Events After Coiling of Asymptomatic Unruptured Intracranial Aneurysms

Neurosurgery ◽  
2012 ◽  
Vol 72 (4) ◽  
pp. 638-645 ◽  
Author(s):  
Dong-Hun Kang ◽  
Yang-Ha Hwang ◽  
Yong-Sun Kim ◽  
Geum Ye Bae ◽  
Seung Jae Lee
Keyword(s):  
Cognitive Deficits ◽  
Coil Embolization ◽  
Intracranial Aneurysms ◽  
Cognitive Outcome ◽  
Cognitively Impaired ◽  
Thromboembolic Events ◽  
Cognitive Changes ◽  
Focal Neurological Deficit ◽  
Unruptured Intracranial Aneurysms ◽  
Significant Difference

Abstract BACKGROUND: Thromboembolic events are the most common complication after coiling of unruptured intracranial aneurysms (UIAs). However, it remains unclear whether these clinically silent ischemic lesions (CSILs) have any clinical significance. OBJECTIVE: To evaluate cognitive outcome after coil embolization of asymptomatic UIAs and its relationship with CSILs after the procedure. METHODS: We prospectively enrolled 40 UIA patients who showed no new focal neurological deficit after coil embolization. CSILs were assessed with diffusion-weighted imaging (DWI) within 1 day after the procedure. A battery of neuropsychological tests was performed 3 times: preoperatively and postoperatively at 1 and 4 weeks after coil embolization. RESULTS: The incidence of cognitive impairment after coiling in patients with UIAs was 44% (17 of 39) at 1 week and 19% (7 of 37) at 4 weeks after coil embolization. DWI within 1 day after coil embolization revealed that 60% of patients (24 of 40) showed CSILs. However, no significant difference was found in any mean cognitive scores or in the number of cognitively impaired variables between patients with and without CSILs at weeks 1 and 4. Additional correlation analysis revealed no correlations between the number of CSILs on DWI and the cognitive sum z score at both 1 and 4 weeks. CONCLUSION: Exhaustive neuropsychological evaluation of UIA patients who underwent coil embolization demonstrated recovery or improvements from baseline cognitive function after 4 weeks, although some patients still showed cognitive deficits at 4 weeks after the procedure. However, we found no statistically significant relationship between the presence and number of CSILs on DWI and cognitive changes after the procedure.

Prophylactic administration of tirofiban for preventing thromboembolic events in flow diversion treatment of intracranial aneurysms

2020 ◽  
pp. neurintsurg-2020-016878
Author(s):  
Qiaowei Wu ◽  
Qiuji Shao ◽  
Li Li ◽  
Xiaodong Liang ◽  
Kaitao Chang ◽  
...  
Keyword(s):  
Balloon Angioplasty ◽  
Intracranial Aneurysms ◽  
Dual Antiplatelet Therapy ◽  
Flow Diverter ◽  
Thromboembolic Events ◽  
Maintenance Infusion ◽  
Prophylactic Administration ◽  
Unruptured Intracranial Aneurysms ◽  
Hemorrhagic Events ◽  
Prophylactic Use

BackgroundFlow diverter (FD) is widely used in the treatment of intracranial aneurysms. However, thromboembolic events (TEs) continue to be the major complications during the periprocedural phase. To evaluate the safety and efficacy of the prophylactic use of tirofiban, combined with the conventional dual antiplatelet therapy (DAT), as a new antiplatelet protocol in patients with intracranial aneurysms treated with FDs.MethodsAt least 3–5 days before the procedure, daily DAT were administrated to the patients. Tirofiban was administered as an intravenous bolus (5 µg/kg) over a 3 min period during or immediately after FD deployment, followed by a 0.05 µg/kg/min maintenance infusion for 24–48 hours. Periprocedural TEs and hemorrhagic events (HEs) were recorded.ResultsA total of 331 patients were included, including 229 (69.2%) who received tirofiban administration (tirofiban group) and 102 (30.8%) who received only DAT (non-tirofiban group). Periprocedural TEs occurred in 12 (3.6%) patients, including eight (7.8%) in the non-tirofiban group and four (1.7%) in the tirofiban group. In multivariate analysis, patients receiving tirofiban administration had significantly lower TEs as compared with those who received only DAT (P=0.004). Balloon angioplasty and longer procedure time (>137 min) were also risk factors for TEs. Also, no increase was observed in the rate of HEs related to tirofiban administration.ConclusionsThe current study suggested that prophylactic administration of tirofiban combined with conventional oral DAT seems safe and efficient for preventing TEs during FD treatment of unruptured intracranial aneurysms. Balloon angioplasty and prolonged procedure are associated with a high risk of TEs.

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