P234 Continuous theta-burst stimulation differentiates children with high-functioning autism spectrum disorder from typically developing children

2020 ◽  
Vol 131 (4) ◽  
pp. e149-e150
Author(s):  
M. Ryan ◽  
A. Jannati ◽  
G. Block ◽  
H. Kaye ◽  
F. Kayarian ◽  
...  
2020 ◽  
Author(s):  
Ali Jannati ◽  
Mary A Ryan ◽  
Gabrielle Block ◽  
Fae B. Kayarian ◽  
Lindsay M. Oberman ◽  
...  

Objective. To assess the utility of the modulation of motor cortex (M1) excitability by continuous theta-burst stimulation (cTBS) as a physiologic biomarker for adults with autism spectrum disorder (ASD), and to evaluate the influences of brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) polymorphisms on cTBS aftereffects. Methods. 44 neurotypical individuals (NT; age 21-65, 34 males) and 19 age-matched adults with high-functioning ASD (age 21-58, 17 males) underwent M1 cTBS. Cortico-motor reactivity was assessed before cTBS and thereafter every 5-10 minutes for 60 minutes (T5-T60). Results. Logistic regressions found cTBS-induced change in amplitude of motor evoked potentials (ΔMEP) at T15 was a significant predictor of ASD diagnosis (p=0.04). ΔMEP at T15 remained a significant predictor of diagnosis among BDNF Met+ subjects and APOEε4- subjects (p-values < 0.05) but not BDNF Met- subjects. ΔMEP at T30 was the best predictor of diagnosis among APOEε4+ subjects (p = 0.08). Conclusions. We confirm previous findings on the utility of cTBS measures of plasticity for adults with ASD, and we find the diagnostic utility of cTBS is modulated by BDNF and APOE SNPs. Significance. It is important to control for BDNF and APOE polymorphisms when comparing TBS aftereffects in ASD and NT individuals.


2018 ◽  
Vol 34 (3) ◽  
pp. 319-334 ◽  
Author(s):  
Rachel Kelly ◽  
Mary-Pat O’Malley ◽  
Stanislava Antonijevic

Difficulty with social communication is the most pervasive difficulty experienced by individuals with high-functioning autism spectrum disorder (HF-ASD). Communication difficulties are often magnified in adolescence as social demands become more intricate. This puts adolescents with HF-ASD at increased risk of social isolation and depression, as they have difficulty developing positive social identity. Yet, there is a dearth of literature addressing the communication issues of this population and even fewer studies including the voice of adolescents with HF-ASD themselves. This study aimed to (1) explore the perspectives of adolescents with HF-ASD as to their social communication skills, (2) explore what (if any) difficulties they perceive themselves as having when talking with their peers, (3) explore if they would like help with social communication skills and (4) determine what kind of help they think may be useful to them and establish if they already use self-initiated strategies. This study was qualitative in nature, using thematic analysis to analyse data collected from 10 semi-structured interviews with 5 adolescents with HF-ASD. Qualitative research underpins the idea that one must understand the significance and explanation that people give to situations, experiences, their own actions and to the actions of others, for one to comprehend human behaviours and actions. A qualitative design allowed us to gain the most in depth insight into how adolescents with HF-ASD understand and perceive their experiences. Three themes emerged revealing the participants’ perceptions of their difficulties communicating, challenging feelings that they experience about communication, and their perspectives about the support for developing communication skills. The participants indicated a need for support to aid their desire to improve communication skills and interactions with typically developing peers. In educational settings, adolescents with HF-ASD may benefit from a peer mentor system to give them opportunities to practice social communication skills with typically developing peers and to encourage inclusion amongst their classmates.


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