Psychomotor performance in healthy young adult volunteers peceiving lormetazepam and placebo: A single-dose, randomized, double-blind, crossover trial

The purpose of this study was to assess the effectiveness of nasopalatine nerve block for anesthesia of maxillary central incisors after failure of the anterior superior alveolar nerve (ASAN) block technique. Secondarily, the possible innervation of the maxillary central incisors by the nasopalatine nerve was also investigated. Twenty-seven healthy, young adult volunteers (age: 17-26 years; gender: 9 males and 18 females) were enrolled in this study. All participants were undergraduate dental students of the University of Vale do Rio Verde de Três Corações. The volunteers had the anterior superior alveolar nerves anesthetized and a thermal sensitivity test (cold) was performed on the maxillary central incisors. The volunteers that responded positively to cold stimulus received a nasopalatine nerve block and the thermal sensitivity test was repeated. All participants were anesthetized by a single operator. Three patients presented sensitivity after both types of bilateral blocks and were excluded from the percentage calculations. In the remaining 24 patients, 16 had their maxillary central incisors anesthetized by the anterior superior alveolar block and 8 remained with sensitivity after the ASAN block. All these 8 patients had their maxillary central incisors successfully anesthetized by the nasopalatine block. In this study, 33.3% of the subjects had the innervation of one or both maxillary central incisors derived from the nasopalatine nerve, whilst most subjects (66.7%) had such teeth innervated by the anterior superior alveolar nerve. The nasopalatine nerve block was effective in anesthetizing the maxillary central incisors when the anterior superior alveolar nerve block failed.

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Efficacy of Venlafaxine for Symptomatic Relief in Young Adult Patients With Functional Chest Pain: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial

Yearbook of Medicine ◽

10.1016/s0084-3873(10)79823-0 ◽

2010 ◽

Vol 2010 ◽

pp. 418-419

Author(s):

K.R. DeVault

Keyword(s):

Chest Pain ◽

Young Adult ◽

Crossover Trial ◽

Symptomatic Relief ◽

Adult Patients ◽

Double Blind ◽

Double Blind Placebo

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P4-251: Validation of a telephone version of the Memory Alteration Test in healthy young adult volunteers

Alzheimer s & Dementia ◽

10.1016/j.jalz.2013.05.1644 ◽

2013 ◽

Vol 9 ◽

pp. P798-P798

Author(s):

Mirian Ecay-Torres ◽

Ainara Estanga ◽

Andrea Izagirre ◽

Arrate Barrenetxea ◽

Ellemarije Altena ◽

...

Keyword(s):

Young Adult ◽

Healthy Young Adult ◽

Adult Volunteers

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The Effect of 2 Injection Speeds on Local Anesthetic Discomfort During Inferior Alveolar Nerve Blocks

Anesthesia Progress ◽

10.2344/11-00037.1 ◽

2015 ◽

Vol 62 (3) ◽

pp. 106-109 ◽

Cited By ~ 4

Author(s):

Marcelo Rodrigo de Souza Melo ◽

Mark Jon Santana Sabey ◽

Carla Juliane Lima ◽

Liane Maciel de Almeida Souza ◽

Francisco Carlos Groppo

Keyword(s):

Pain Perception ◽

Crossover Trial ◽

Healthy Adult ◽

Inferior Alveolar Nerve ◽

Needle Insertion ◽

Test Results ◽

Nerve Blocks ◽

Double Blind ◽

Significant Difference ◽

Adult Volunteers

Abstract This randomized double-blind crossover trial investigated the discomfort associated with 2 injection speeds, low (60 seconds) and slow (100 seconds), during inferior alveolar nerve block by using 1.8 mL of 2% lidocaine with 1 : 100,000 epinephrine. Three phases were considered: (a) mucosa perforation, (b) needle insertion, and (c) solution injection. Thirty-two healthy adult volunteers needing bilateral inferior alveolar nerve blocks at least 1 week apart were enrolled in the present study. The anesthetic procedure discomfort was recorded by volunteers on a 10-cm visual analog scale in each phase for both injection speeds. Comparison between the 2 anesthesia speeds in each phase was performed by paired t test. Results showed no statistically significant difference between injection speeds regarding perforation (P = .1016), needle placement (P = .0584), or speed injection (P = .1806). The discomfort in all phases was considered low. We concluded that the 2 injection speeds tested did not affect the volunteers' pain perception during inferior alveolar nerve blocks.

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