Response letter to the editor: Associations of vitamin D deficiency with MRI markers of brain health in a community sample

Author(s):  
Mirte Boelens ◽  
Pauline H. Croll ◽  
Trudy Voortman
2021 ◽  
Vol 40 (1) ◽  
pp. 72-78 ◽  
Author(s):  
Pauline H. Croll ◽  
Mirte Boelens ◽  
Meike W. Vernooij ◽  
Ondine van de Rest ◽  
M. Carola Zillikens ◽  
...  

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Roland Mergl ◽  
Ezgi Dogan-Sander ◽  
Anja Willenberg ◽  
Kerstin Wirkner ◽  
Jürgen Kratzsch ◽  
...  

Abstract Background Sleep disorders and vitamin D deficiency are highly prevalent health problems. Few studies examined the effect of vitamin D concentrations on objectively measured sleep with high methodological quality and temporal proximity. Previous analysis within the LIFE-Adult-Study suggested that a lower concentration of serum vitamin D was associated with both shorter and later night sleep. However, no conclusion about underlying mechanisms could be drawn. We addressed the question whether this relationship is explained by the presence of depressive syndromes, which are linked to both vitamin D deficiency and sleep disturbances. Methods It was investigated whether the association of vitamin D concentrations and night sleep parameters is mediated or moderated by depressive symptomatology. We investigated a subset (n = 1252) of the community sample from the LIFE-Adult-Study, in which sleep parameters had been objectively assessed using actigraphy, based on which two sleep parameters were calculated: night sleep duration and midsleep time. Serum 25(OH) D concentrations were measured using an electrochemiluminescence immunoassay. Depressive symptomatology was evaluated with the Centre for Epidemiological Studies Depression Scale. The mediation effect was analyzed by using Hayes’ PROCESS macro tool for SPSS for Windows. Results The depressive symptomatology was neither significantly associated with night sleep duration nor midsleep time. The associations between vitamin D concentrations and night sleep duration/midsleep time through mediation by depressive symptomatology were not significant. Corresponding moderator analyses were also non-significant. Conclusion The associations between vitamin D concentrations and night sleep parameters (sleep duration and midsleep time) seem to be neither mediated nor moderated by depressive symptomatology.


2018 ◽  
Vol 104 (2) ◽  
pp. 339-340
Author(s):  
Fahimeh Ramezani Tehrani ◽  
Sonia Minooee ◽  
Maryam Rostami ◽  
Razieh Bidhendi Yarandi ◽  
Farhad Hosseinpanah

Metabolism ◽  
2020 ◽  
pp. 154434
Author(s):  
Joost Smolders ◽  
Jody van den Ouweland ◽  
Christopher Geven ◽  
Peter Pickkers ◽  
Matthijs Kox

Author(s):  
Maria Eduarda Rodrigues Alves dos Santos ◽  
Waleska Maria Almeida Barros ◽  
Matheus Santos de Sousa Fernandes ◽  
Ana Beatriz Januário da Silva ◽  
Viviane de Oliveira Nogueira Souza

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